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Drug ReportsHeparin
Heparin
Calciparine, Defencath, Embolex, Heparin (heparin) is an unknown pharmaceutical. Heparin was first approved as Calciparine on 1982-01-01. It is used to treat cerebral infarction, coronary thrombosis, myocardial infarction, postoperative complications, and pulmonary embolism amongst others in the USA. The pharmaceutical is active against antithrombin-III. In addition, it is known to target epidermal growth factor receptor and receptor tyrosine-protein kinase erbB-4.
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YTD
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
respiratory tract diseasesD012140
nervous system diseasesD009422
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Heparin (discontinued: Calciparine, Heparin, Lipo-hepin, Liquaemin)
Combinations
Defencath (discontinued: Embolex)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Heparin calcium
Tradename
Company
Number
Date
Products
CALCIPARINESanofiN-018237 DISCN1982-01-01
1 products
Hide discontinued
Dihydroergotamine mesylate
+
Heparin sodium
+
Lidocaine hydrochloride
Tradename
Company
Number
Date
Products
EMBOLEXNovartisN-018885 DISCN1984-11-30
2 products
Hide discontinued
Heparin sodium
Tradename
Company
Number
Date
Products
HEPARIN SODIUM 1,000 UNITS IN SODIUM CHLORIDE 0.9% IN PLASTIC CONTAINERB. Braun MedicalN-019953 RX1992-07-20
1 products, RLD, RS
HEPARIN SODIUM 2,000 UNITS IN SODIUM CHLORIDE 0.9% IN PLASTIC CONTAINERB. Braun MedicalN-019953 RX2023-12-15
1 products, RLD, RS
HEPARIN SODIUM 20,000 UNITS IN DEXTROSE 5% IN PLASTIC CONTAINERB. Braun MedicalN-019952 RX1992-07-20
1 products, RLD, RS
HEPARIN SODIUM 25,000 UNITS IN DEXTROSE 5% IN PLASTIC CONTAINERB. Braun MedicalN-019952 RX1992-07-20
2 products, RLD, RS
HEPARIN SODIUM 1,000 UNITS AND SODIUM CHLORIDE 0.9% IN PLASTIC CONTAINERBaxterN-018609 RX1982-04-28
1 products
HEPARIN SODIUM 2,000 UNITS AND SODIUM CHLORIDE 0.9% IN PLASTIC CONTAINERBaxterN-018609 RX1982-04-28
1 products
HEPARIN SODIUMFresenius KabiN-017029 RX1982-01-01
3 products, RLD, RS
HEPARIN SODIUM PRESERVATIVE FREEFresenius KabiN-017029 RX1986-04-28
1 products, RLD, RS
HEPARIN SODIUM IN PLASTIC CONTAINERFresenius KabiN-017029 RX1985-12-05
4 products, RLD, RS
HEPARIN SODIUM PRESERVATIVE FREEFresenius KabiN-017029 RX2010-11-22
1 products, RLD, RS
Show 15 marketed
Show 58 discontinued
Heparin sodium
+
Taurolidine
Tradename
Company
Number
Date
Products
DEFENCATHCorMedixN-214520 RX2023-11-15
2 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
defencathNew Drug Application2024-12-23
heparinunapproved drug other2012-08-09
heparin sodiumunapproved drug other2014-12-24
heparin sodiumANDA2024-11-22
heparin sodium and dextroseNew Drug Application2024-11-30
heparin sodium and sodium chlorideNew Drug Application2019-04-19
heparin sodium in dextroseNew Drug Application2023-07-31
heparin sodium in sodium chlorideNew Drug Application2024-01-27
iceking freckle removing whitening facial cleanser iceking freckle removing whitening masque iceking refresh armpit iceking repellent mosquito icek...Export only2018-07-23
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
myocardial infarctionEFO_0000612D009203I21
pulmonary embolismHP_0002204D011655I26
postoperative complications—D011183—
thromboembolismHP_0001907D013923—
cerebral infarction—D002544I63
coronary thrombosisEFO_1000883D003328I21
unstable anginaEFO_1000985D000789I20.0
thrombophlebitisHP_0004418D013924—
migraine disordersEFO_0003821D008881G43
painEFO_0003843D010146R52
Show 12 more
Agency Specific
FDA
EMA
Expiration
Code
HEPARIN SODIUM / TAUROLIDINE, DEFENCATH, CORMEDIX
2033-11-15GAIN
2028-11-15NCE
Patent Expiration
Patent
Expires
Flag
FDA Information
Heparin Sodium / Taurolidine, Defencath, Cormedix
117381202042-04-15DS, DP
76961822025-05-16DS, DPU-3774
85413932024-11-02DS, DPU-3774
93390362024-11-02DS, DP
ATC Codes
B: Blood and blood forming organ drugs
— B01: Antithrombotic agents
— B01A: Antithrombotic agents
— B01AB: Heparin group antithrombotic drugs
— B01AB01: Heparin
— B01AB51: Heparin, combinations
— B01AC: Platelet aggregation inhibitors excl. heparin
— B01AC30: Platelet aggregation inhibitor combinations excl. heparin
C: Cardiovascular system drugs
— C05: Vasoprotectives
— C05B: Antivaricose therapy drugs
— C05BA: Heparins or heparinoids for topical use
— C05BA03: Heparin
— C05BA53: Heparin, combinations
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01X: Other ophthalmologicals in atc
— S01XA: Other ophthalmologicals in atc
— S01XA14: Heparin
HCPCS
Code
Description
B4216
Parenteral nutrition; additives (vitamins, trace elements, heparin, electrolytes), home mix, per day
E1520
Heparin infusion pump for hemodialysis
J1642
Injection, heparin sodium, (heparin lock flush), per 10 units
J1643
Injection, heparin sodium (pfizer), not therapeutically equivalent to j1644, per 1000 units
J1644
Injection, heparin sodium, per 1000 units
S2120
Low density lipoprotein (ldl) apheresis using heparin-induced extracorporeal ldl precipitation
S9336
Home infusion therapy, continuous anticoagulant infusion therapy (e.g., heparin), administrative services, professional pharmacy services, care coordination and all necessary supplies and equipment (drugs and nursing visits coded separately), per diem
S9372
Home therapy; intermittent anticoagulant injection therapy (e.g., heparin); administrative services, professional pharmacy services, care coordination, and all necessary supplies and equipment (drugs and nursing visits coded separately), per diem (do not use this code for flushing of infusion devices with heparin to maintain patency)
Clinical
No data
Drug
General
Drug common nameHeparin
INNheparin sodium
Description
Heparin, also known as unfractionated heparin (UFH), is a medication and naturally occurring glycosaminoglycan. Heparin is a blood anticoagulant that increases the activity of antithrombin. It is used in the treatment of heart attacks and unstable angina. It can be given intravenously or by injection under the skin. Its anticoagulant properties make it useful to prevent blood clotting in blood specimen test tubes and kidney dialysis machines.
Classification
Protein
Drug class—
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)—
Identifiers
PDB—
CAS-ID9005-49-6
RxCUI5224
ChEMBL IDCHEMBL1909300
ChEBI ID—
PubChem CID22833565
DrugBankDB01109
UNII IDZZ45AB24CA (ChemIDplus, GSRS)
Target
Agency Approved
SERPINC1
SERPINC1
Organism
Homo sapiens
Gene name
SERPINC1
Gene synonyms
AT3
NCBI Gene ID
462
Protein name
antithrombin-III
Protein synonyms
serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1, Serpin C1, serpin peptidase inhibitor clade C member 1, serpin peptidase inhibitor, clade C (antithrombin), member 1
Uniprot ID
Q9UC78
Mouse ortholog
Serpinc1 (11905)
antithrombin-III (P32261)
Alternate
EGFR
EGFR
ERBB4
ERBB4
Organism
Homo sapiens
Gene name
EGFR
Gene synonyms
ERBB, ERBB1, HER1
NCBI Gene ID
1956
Protein name
epidermal growth factor receptor
Protein synonyms
avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, cell growth inhibiting protein 40, cell proliferation-inducing protein 61, EGFR vIII, epidermal growth factor receptor tyrosine kinase domain, erb-b2 receptor tyrosine kinase 1, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1
Uniprot ID
Q9UMG5
Mouse ortholog
Egfr (13649)
epidermal growth factor receptor (Q01279)
Variants
No data
Financial
Revenue by drug
$
€
£
₣
No data
Estimated US medical usage
Heparin
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Tabular view
Trends
No data
Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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