Heparin
Calciparine, Defencath, Embolex, Heparin (heparin) is an unknown pharmaceutical. Heparin was first approved as Calciparine on 1982-01-01. It is used to treat cerebral infarction, coronary thrombosis, myocardial infarction, postoperative complications, and pulmonary embolism amongst others in the USA. The pharmaceutical is active against antithrombin-III. In addition, it is known to target epidermal growth factor receptor and receptor tyrosine-protein kinase erbB-4.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Heparin (discontinued: Calciparine, Heparin, Lipo-hepin, Liquaemin)
CombinationsDefencath (discontinued: Embolex)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Heparin calcium
Dihydroergotamine mesylate
+
Heparin sodium
+
Lidocaine hydrochloride
Heparin sodium
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| HEPARIN SODIUM 1,000 UNITS IN SODIUM CHLORIDE 0.9% IN PLASTIC CONTAINER | B. Braun Medical | N-019953 RX | 1992-07-20 | 1 products, RLD, RS |
| HEPARIN SODIUM 2,000 UNITS IN SODIUM CHLORIDE 0.9% IN PLASTIC CONTAINER | B. Braun Medical | N-019953 RX | 2023-12-15 | 1 products, RLD, RS |
| HEPARIN SODIUM 25,000 UNITS IN SODIUM CHLORIDE 0.45% IN PLASTIC CONTAINER | B. Braun Medical | N-019953 RX | 2025-03-25 | 2 products, RLD, RS |
| HEPARIN SODIUM 20,000 UNITS IN DEXTROSE 5% IN PLASTIC CONTAINER | B. Braun Medical | N-019952 RX | 1992-07-20 | 1 products, RLD, RS |
| HEPARIN SODIUM 25,000 UNITS IN DEXTROSE 5% IN PLASTIC CONTAINER | B. Braun Medical | N-019952 RX | 1992-07-20 | 2 products, RLD, RS |
| HEPARIN SODIUM 1,000 UNITS AND SODIUM CHLORIDE 0.9% IN PLASTIC CONTAINER | Baxter | N-018609 RX | 1982-04-28 | 1 products |
| HEPARIN SODIUM 2,000 UNITS AND SODIUM CHLORIDE 0.9% IN PLASTIC CONTAINER | Baxter | N-018609 RX | 1982-04-28 | 1 products |
| HEPARIN SODIUM | Fresenius Kabi | N-017029 RX | 1982-01-01 | 3 products, RLD, RS |
| HEPARIN SODIUM PRESERVATIVE FREE | Fresenius Kabi | N-017029 RX | 1986-04-28 | 1 products, RLD, RS |
| HEPARIN SODIUM IN PLASTIC CONTAINER | Fresenius Kabi | N-017029 RX | 1985-12-05 | 4 products, RLD, RS |
Show 14 marketed
Show 59 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| defencath | New Drug Application | 2025-09-29 |
| heparin | unapproved drug other | 2012-08-09 |
| heparin sodium | unapproved drug other | 2014-12-24 |
| heparin sodium | New Drug Application | 2026-01-16 |
| heparin sodium and dextrose | New Drug Application | 2025-11-14 |
| heparin sodium and sodium chloride | New Drug Application | 2019-04-19 |
| heparin sodium in dextrose | New Drug Application | 2023-07-31 |
| heparin sodium in sodium chloride | New Drug Application | 2025-08-06 |
| iceking freckle removing whitening facial cleanser iceking freckle removing whitening masque iceking refresh armpit iceking repellent mosquito icek... | Export only | 2018-07-23 |
Indications
FDA
EMA
Show 12 more
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
HEPARIN SODIUM / TAUROLIDINE, DEFENCATH, CORMEDIX | |||
| 2033-11-15 | GAIN | ||
| 2028-11-15 | NCE | ||
ATC Codes
B: Blood and blood forming organ drugs
— B01: Antithrombotic agents
— B01A: Antithrombotic agents
— B01AB: Heparin group antithrombotic drugs
— B01AB01: Heparin
— B01AB51: Heparin, combinations
— B01AC: Platelet aggregation inhibitors excl. heparin
— B01AC30: Platelet aggregation inhibitor combinations excl. heparin
C: Cardiovascular system drugs
— C05: Vasoprotectives
— C05B: Antivaricose therapy drugs
— C05BA: Heparins or heparinoids for topical use
— C05BA03: Heparin
— C05BA53: Heparin, combinations
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01X: Other ophthalmologicals in atc
— S01XA: Other ophthalmologicals in atc
— S01XA14: Heparin
HCPCS
Code | Description |
|---|---|
| B4216 | Parenteral nutrition; additives (vitamins, trace elements, heparin, electrolytes), home mix, per day |
| E1520 | Heparin infusion pump for hemodialysis |
| J1642 | Injection, heparin sodium, (heparin lock flush), per 10 units |
| J1643 | Injection, heparin sodium (pfizer), not therapeutically equivalent to j1644, per 1000 units |
| J1644 | Injection, heparin sodium, per 1000 units |
| S2120 | Low density lipoprotein (ldl) apheresis using heparin-induced extracorporeal ldl precipitation |
| S9336 | Home infusion therapy, continuous anticoagulant infusion therapy (e.g., heparin), administrative services, professional pharmacy services, care coordination and all necessary supplies and equipment (drugs and nursing visits coded separately), per diem |
| S9372 | Home therapy; intermittent anticoagulant injection therapy (e.g., heparin); administrative services, professional pharmacy services, care coordination, and all necessary supplies and equipment (drugs and nursing visits coded separately), per diem (do not use this code for flushing of infusion devices with heparin to maintain patency) |
Clinical
Clinical Trials
1718 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Thrombosis | D013927 | — | — | 12 | 36 | 59 | 49 | 98 | 240 |
| Thromboembolism | D013923 | — | — | 8 | 37 | 74 | 38 | 66 | 212 |
| Venous thromboembolism | D054556 | EFO_0004286 | I74 | 8 | 36 | 73 | 30 | 66 | 203 |
| Venous thrombosis | D020246 | — | I82.40 | 7 | 28 | 47 | 39 | 60 | 172 |
| Covid-19 | D000086382 | — | U07.1 | 6 | 27 | 35 | 14 | 39 | 107 |
| Pulmonary embolism | D011655 | EFO_0003827 | I26 | 9 | 10 | 33 | 25 | 29 | 101 |
| Embolism | D004617 | — | — | 8 | 8 | 25 | 19 | 22 | 77 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | 4 | 18 | 23 | 25 | 69 |
| Hemorrhage | D006470 | MP_0001914 | R58 | 1 | 6 | 12 | 13 | 24 | 55 |
| Infarction | D007238 | EFO_0009463 | — | — | 4 | 10 | 17 | 25 | 55 |
Show 184 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 18 | 3 | 1 | — | 5 | 25 |
| Septic shock | D012772 | — | A48.3 | 2 | 4 | 2 | — | 14 | 22 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | 2 | 5 | — | 14 | 21 |
| Multiple myeloma | D009101 | — | C90.0 | 3 | 4 | 2 | — | 5 | 13 |
| Pain | D010146 | EFO_0003843 | R52 | — | 1 | 2 | — | 11 | 13 |
| Replacement arthroplasty knee | D019645 | — | — | — | 5 | 3 | — | 1 | 9 |
| Plasma cell neoplasms | D054219 | — | — | 3 | 3 | 1 | — | 3 | 9 |
| Newborn respiratory distress syndrome | D012127 | — | P22 | 2 | 4 | 2 | — | 4 | 9 |
| Lymphoma | D008223 | — | C85.9 | 2 | 3 | 1 | — | 3 | 8 |
| Coagulation protein disorders | D020147 | — | — | 1 | — | 2 | — | 5 | 8 |
Show 109 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cholangiocarcinoma | D018281 | — | C22.1 | 1 | 5 | — | — | 1 | 7 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | — | 4 | — | — | 2 | 6 |
| Coronary stenosis | D023921 | EFO_1000882 | — | — | 1 | — | — | 4 | 5 |
| Congenital heart defects | D006330 | — | Q24.9 | 1 | 1 | — | — | 3 | 5 |
| Carotid artery diseases | D002340 | EFO_0003781 | — | — | 1 | — | — | 3 | 4 |
| Myeloid leukemia | D007951 | — | C92 | 3 | 1 | — | — | — | 4 |
| Systemic inflammatory response syndrome | D018746 | EFO_1001478 | R65.10 | — | 1 | — | — | 3 | 4 |
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | 1 | 2 | — | — | 1 | 3 |
| B-cell lymphoma | D016393 | — | — | 2 | 2 | — | — | — | 3 |
| Kidney neoplasms | D007680 | EFO_0003865 | C64 | 1 | 1 | — | — | 2 | 3 |
Show 70 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Blood platelet disorders | D001791 | — | — | 1 | — | — | — | 3 | 4 |
| Blood pressure | D001794 | EFO_0004325 | — | 2 | — | — | — | 1 | 3 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 1 | — | — | — | 1 | 2 |
| Hodgkin disease | D006689 | — | C81 | 1 | — | — | — | 1 | 2 |
| Congenital abnormalities | D000013 | EFO_0003915 | Q89.9 | 1 | — | — | — | 1 | 2 |
| Systemic lupus erythematosus | D008180 | EFO_0002690 | M32 | 1 | — | — | — | 1 | 2 |
| Neuroblastoma | D009447 | EFO_0000621 | — | 1 | — | — | — | 1 | 2 |
| Sensorineural hearing loss | D006319 | — | H90.5 | 1 | — | — | — | 1 | 2 |
| Nasopharyngeal carcinoma | D000077274 | — | — | 1 | — | — | — | — | 1 |
| Nasopharyngeal neoplasms | D009303 | — | — | 1 | — | — | — | — | 1 |
Show 23 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Postoperative complications | D011183 | — | — | — | — | — | — | 6 | 6 |
| Carotid stenosis | D016893 | — | — | — | — | — | — | 6 | 6 |
| Chest pain | D002637 | — | R07.9 | — | — | — | — | 5 | 5 |
| Pathologic constriction | D003251 | — | — | — | — | — | — | 5 | 5 |
| Non-alcoholic fatty liver disease | D065626 | EFO_0003095 | K75.81 | — | — | — | — | 4 | 4 |
| Post-acute covid-19 syndrome | D000094024 | — | — | — | — | — | — | 4 | 4 |
| Cytokine release syndrome | D000080424 | — | D89.83 | — | — | — | — | 3 | 3 |
| Blood coagulation | D001777 | GO_0007596 | — | — | — | — | — | 3 | 3 |
| Esophageal and gastric varices | D004932 | EFO_0009545 | I85 | — | — | — | — | 3 | 3 |
| Platelet aggregation | D010974 | GO_0070527 | — | — | — | — | — | 3 | 3 |
Show 226 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Heparin |
| INN | heparin sodium |
| Description | Heparin, also known as unfractionated heparin (UFH), is a medication and naturally occurring glycosaminoglycan. Heparin is a blood anticoagulant that increases the activity of antithrombin. It is used in the treatment of heart attacks and unstable angina. It can be given intravenously or by injection under the skin. Its anticoagulant properties make it useful to prevent blood clotting in blood specimen test tubes and kidney dialysis machines.
|
| Classification | Protein |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | 9005-49-6 |
| RxCUI | 5224 |
| ChEMBL ID | CHEMBL1909300 |
| ChEBI ID | — |
| PubChem CID | 22833565 |
| DrugBank | DB01109 |
| UNII ID | ZZ45AB24CA (ChemIDplus, GSRS) |
Target
Agency Approved
SERPINC1
SERPINC1
Organism
Homo sapiens
Gene name
SERPINC1
Gene synonyms
AT3
NCBI Gene ID
Protein name
antithrombin-III
Protein synonyms
serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1, Serpin C1, serpin peptidase inhibitor clade C member 1, serpin peptidase inhibitor, clade C (antithrombin), member 1
Uniprot ID
Mouse ortholog
Serpinc1 (11905)
antithrombin-III (P32261)
Alternate
EGFR
EGFR
ERBB4
ERBB4
Organism
Homo sapiens
Gene name
EGFR
Gene synonyms
ERBB, ERBB1, HER1
NCBI Gene ID
Protein name
epidermal growth factor receptor
Protein synonyms
avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, cell growth inhibiting protein 40, cell proliferation-inducing protein 61, EGFR vIII, epidermal growth factor receptor tyrosine kinase domain, erb-b2 receptor tyrosine kinase 1, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1
Uniprot ID
Mouse ortholog
Egfr (13649)
epidermal growth factor receptor (Q01279)
Variants
No data
Financial
Revenue by drug
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Estimated US medical usage
Heparin
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
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Additional graphs summarizing 217,110 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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36,059 adverse events reported
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