Tenex, Intuniv(guanfacine)
Guanfacine, Intuniv (guanfacine) is a small molecule pharmaceutical. Guanfacine was first approved as Tenex on 1986-10-27. It is used to treat attention deficit disorder with hyperactivity and hypertension in the USA. It has been approved in Europe to treat attention deficit disorder with hyperactivity.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| cardiovascular diseases | D002318 |
| mental disorders | D001523 |
Trade Name
FDA
EMA
Guanfacine, Intuniv (discontinued: Guanfacine, Tenex)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| guanfacine | ANDA | 2026-08-03 |
| guanfacine er | ANDA | 2025-01-22 |
| guanfacine extended-release | ANDA | 2026-05-06 |
| guanfacine hydrochloride | ANDA | 2026-05-22 |
| intuniv | New Drug Application | 2025-06-23 |
| tenex | New Drug Application | 2013-05-08 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| hypertension | EFO_0000537 | D006973 | I10 |
| attention deficit disorder with hyperactivity | EFO_0003888 | D001289 | F90 |
Agency Specific
FDA
EMA
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Patent Expiration
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HCPCS
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Clinical
Clinical Trials
97 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
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Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Attention deficit disorder with hyperactivity | D001289 | EFO_0003888 | F90 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Guanfacine |
| INN | guanfacine |
| Description | Guanfacine is a member of acetamides. |
| Classification | Small molecule |
| Drug class | antihypertensives (guanidine deriviatives) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | N=C(N)NC(=O)Cc1c(Cl)cccc1Cl |
Identifiers
| PDB | — |
| CAS-ID | 29110-47-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL862 |
| ChEBI ID | 5558 |
| PubChem CID | 3519 |
| DrugBank | DB01018 |
| UNII ID | 30OMY4G3MK (ChemIDplus, GSRS) |
Target
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Variants
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Financial
Estimated US medical usage
Guanfacine
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
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Additional graphs summarizing 4,504 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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4,422 adverse events reported
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