Gonadorelin
Factrel, Lutrepulse (gonadorelin) is a protein pharmaceutical. Gonadorelin was first approved as Factrel on 1982-09-30. It is used to treat amenorrhea, delayed puberty, ovarian cysts, and precocious puberty in the USA.
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Gonadorelin hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| FACTREL | Hikma Pharmaceuticals | N-018123 DISCN | 1982-09-30 | 3 products |
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Gonadorelin acetate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| LUTREPULSE KIT | Ferring Pharmaceuticals | N-019687 DISCN | 1989-10-10 | 2 products |
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Indications
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EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| amenorrhea | — | D000568 | N91.2 |
| precocious puberty | — | D011629 | E22.8 |
| ovarian cysts | HP_0000138 | D010048 | N83.1 |
| delayed puberty | HP_0000823 | D011628 | E30.0 |
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ATC Codes
H: Systemic hormonal preparations, excl. sex hormones and insulins
— H01: Pituitary and hypothalamic hormones and analogues
— H01C: Hypothalamic hormones
— H01CA: Gonadotropin-releasing hormones
— H01CA01: Gonadorelin
V: Various drug classes in atc
— V04: Diagnostic agents
— V04C: Other diagnostic agents in atc
— V04CM: Fertility disturbances test diagnostic agents
— V04CM01: Gonadorelin
HCPCS
Code | Description |
|---|---|
| J1620 | Injection, gonadorelin hydrochloride, per 100 mcg |
Clinical
Clinical Trials
523 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Prostatic neoplasms | D011471 | — | C61 | 21 | 95 | 58 | 8 | 34 | 207 |
| Infertility | D007246 | HP_0000789 | — | 4 | 16 | 14 | 21 | 39 | 88 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 4 | 27 | 23 | 1 | 9 | 62 |
| Endometriosis | D004715 | EFO_0001065 | N80 | 1 | 6 | 6 | 2 | 10 | 23 |
| Hypogonadism | D007006 | HP_0000044 | E23.0 | 5 | 4 | 1 | 2 | 11 | 23 |
| Female infertility | D007247 | EFO_0008560 | N97 | 2 | 6 | 3 | 4 | 11 | 22 |
| Syndrome | D013577 | — | — | 3 | 1 | 2 | 3 | 3 | 11 |
| Fertilization in vitro | D005307 | — | — | — | — | 2 | 3 | 4 | 9 |
| Ovulation induction | D010062 | — | — | — | 1 | 2 | 2 | 4 | 9 |
| Kallmann syndrome | D017436 | Orphanet_478 | E23.0 | 3 | 2 | — | 1 | 3 | 9 |
Show 36 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Adenocarcinoma | D000230 | — | — | 2 | 13 | 6 | — | 1 | 21 |
| Hypersensitivity | D006967 | HP_0012393 | T78.40 | — | 7 | 8 | — | 3 | 18 |
| Neoplasms | D009369 | — | C80 | 2 | 5 | 3 | — | 2 | 12 |
| Recurrence | D012008 | — | — | 1 | 3 | 3 | — | 4 | 10 |
| Triple negative breast neoplasms | D064726 | — | — | — | 4 | 5 | — | 1 | 10 |
| Carcinoma | D002277 | — | C80.0 | 2 | 5 | 1 | — | — | 7 |
| Adenomyosis | D062788 | EFO_1001757 | N80.0 | — | 2 | 3 | — | 4 | 7 |
| Primary ovarian insufficiency | D016649 | EFO_0004266 | E28.3 | 1 | 3 | 1 | — | 1 | 5 |
| Hyperplasia | D006965 | EFO_0000536 | — | — | 5 | 3 | — | — | 5 |
| Endometrial neoplasms | D016889 | EFO_0004230 | — | — | 4 | 2 | — | 1 | 5 |
Show 25 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Premature menopause | D008594 | HP_0008209 | E28.31 | 1 | 2 | — | — | 1 | 3 |
| Male breast neoplasms | D018567 | — | — | — | 3 | — | — | — | 3 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | — | 3 | — | — | — | 3 |
| Salivary gland neoplasms | D012468 | EFO_0003826 | D11 | — | 2 | — | — | — | 2 |
| Ectopic pregnancy | D011271 | — | O00 | 1 | 1 | — | — | 1 | 2 |
| Hyperprolactinemia | D006966 | HP_0000870 | E22.1 | 1 | 1 | — | — | — | 2 |
| Lower urinary tract symptoms | D059411 | EFO_0008008 | — | — | 1 | — | — | 1 | 2 |
| Fatigue | D005221 | HP_0012378 | R53.83 | — | 2 | — | — | — | 2 |
| Bone marrow diseases | D001855 | — | — | — | 1 | — | — | 1 | 2 |
| Infections | D007239 | EFO_0000544 | — | 1 | 1 | — | — | — | 1 |
Show 17 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Transgenes | D019076 | — | — | 1 | — | — | — | 1 | 2 |
| Cocaine-related disorders | D019970 | — | F14 | 1 | — | — | — | — | 1 |
| Hiv | D006678 | — | — | 1 | — | — | — | — | 1 |
| Antibiotic prophylaxis | D019072 | — | — | 1 | — | — | — | — | 1 |
| Cerebral arterial diseases | D002539 | EFO_1000859 | — | 1 | — | — | — | — | 1 |
| Menstruation disturbances | D008599 | HP_0400007 | N91.5 | 1 | — | — | — | — | 1 |
| Premenstrual syndrome | D011293 | — | N94.3 | 1 | — | — | — | — | 1 |
| Cohort studies | D015331 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Gender dysphoria | D000068116 | — | — | — | — | — | — | 4 | 4 |
| Pregnancy rate | D018873 | — | — | — | — | — | — | 2 | 2 |
| Insulin resistance | D007333 | HP_0000855 | — | — | — | — | — | 2 | 2 |
| Gender identity | D005783 | — | — | — | — | — | — | 2 | 2 |
| Premature cardiac complexes | D005117 | — | I49.40 | — | — | — | — | 1 | 1 |
| Wounds and injuries | D014947 | — | T14.8 | — | — | — | — | 1 | 1 |
| Spinal cord injuries | D013119 | EFO_1001919 | — | — | — | — | — | 1 | 1 |
| Congenital abnormalities | D000013 | EFO_0003915 | Q89.9 | — | — | — | — | 1 | 1 |
| Heart disease risk factors | D000082742 | — | — | — | — | — | — | 1 | 1 |
| Gonadal disorders | D006058 | — | — | — | — | — | — | 1 | 1 |
Show 29 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Gonadorelin |
| INN | gonadorelin |
| Description | Gonadorelin is a ten-membered synthetic oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, glycyl, leucyl, arginyl, prolyl and glycinamide residues joined in sequence. It has a role as a gonadotropin releasing hormone agonist. It is an oligopeptide and a peptide hormone. |
| Classification | Protein |
| Drug class | prehormones or hormone-release stimulating peptides |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)C[C@H](NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O |
Identifiers
| PDB | — |
| CAS-ID | 33515-09-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1007 |
| ChEBI ID | 5520 |
| PubChem CID | 638793 |
| DrugBank | DB00644 |
| UNII ID | 9O7312W37G (ChemIDplus, GSRS) |
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326 adverse events reported
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