Glucosamine
Glucosamine is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target P2Y purinoceptor 14.
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Commercial
Therapeutic Areas
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Drug Products
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New Drug Application (NDA)
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Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| acts38 boswelliagel | unapproved drug other | 2022-09-07 |
| acts38 boswelliagel (100ml) | unapproved drug other | 2022-10-22 |
| banpinghua glucosamine chondroitin patch | C200263 | 2025-11-06 |
| deguli | unapproved drug other | 2022-02-21 |
| floriva | unapproved drug other | 2024-02-02 |
| glucosamine cream extra strength | C200263 | 2024-12-30 |
| glucosamine sulfate, chondroitin sulfate, ibuprofen | Export only | 2025-06-30 |
| goodoh energycream | unapproved drug other | 2023-11-30 |
| implaheal p.ocream | unapproved drug other | 2020-01-04 |
| jba joint revive | unapproved drug other | 2025-03-31 |
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Clinical
Clinical Trials
147 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | 3 | 2 | 11 | 9 | 26 | 50 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | 3 | 2 | 7 | 8 | 22 | 41 |
| Covid-19 | D000086382 | — | U07.1 | 1 | 1 | 2 | 1 | 1 | 5 |
| Diabetic nephropathies | D003928 | EFO_0000401 | — | — | — | 2 | 2 | — | 4 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | — | 3 | 1 | — | 4 |
| Syndrome | D013577 | — | — | — | 1 | 3 | 1 | — | 4 |
| Back pain | D001416 | — | M54 | — | — | — | 2 | 2 | 4 |
| Inflammation | D007249 | MP_0001845 | — | — | — | — | 1 | 3 | 4 |
| Low back pain | D017116 | — | M54.5 | — | — | — | 1 | 2 | 3 |
| Weight loss | D015431 | — | — | — | — | — | 1 | 1 | 2 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Muscular diseases | D009135 | EFO_0002970 | G72.9 | — | 2 | 2 | — | — | 4 |
| Distal myopathies | D049310 | — | G71.09 | — | 2 | 2 | — | — | 4 |
| Inclusion body myositis | D018979 | EFO_0007323 | G72.41 | — | 1 | 2 | — | — | 3 |
| Non-small-cell lung carcinoma | D002289 | — | — | — | 1 | 1 | — | — | 2 |
| Lung diseases | D008171 | EFO_0003818 | J98.4 | — | 1 | 1 | — | — | 2 |
| Peripheral arterial disease | D058729 | EFO_0004265 | — | — | — | 1 | — | 1 | 2 |
| Pulpitis | D011671 | EFO_1001139 | K04.0 | — | — | 1 | — | 1 | 2 |
| Ulcer | D014456 | MPATH_579 | — | 1 | — | 1 | — | — | 2 |
| Irritable bowel syndrome | D043183 | EFO_0000555 | K58 | — | 1 | 2 | — | — | 2 |
| Carcinoma | D002277 | — | C80.0 | — | 1 | 2 | — | — | 2 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Arthralgia | D018771 | — | M25.5 | — | 2 | — | — | 3 | 5 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | 2 | — | — | 1 | 4 |
| Respiratory tract neoplasms | D012142 | EFO_0003853 | D14 | — | 1 | — | — | — | 1 |
| Bronchogenic carcinoma | D002283 | — | — | — | 1 | — | — | — | 1 |
| Thoracic neoplasms | D013899 | — | — | — | 1 | — | — | — | 1 |
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | — | 1 | — | — | — | 1 |
| Severe acute malnutrition | D000067011 | — | — | — | 1 | — | — | — | 1 |
| Tinnitus | D014012 | — | H93.1 | — | 1 | — | — | — | 1 |
| Retinal diseases | D012164 | — | H35.9 | — | 1 | — | — | — | 1 |
| Diabetic retinopathy | D003930 | EFO_0003770 | — | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Obesity | D009765 | EFO_0001073 | E66.9 | 1 | — | — | — | 1 | 2 |
| Overweight | D050177 | — | E66.3 | 1 | — | — | — | 1 | 2 |
| Venous insufficiency | D014689 | — | — | 1 | — | — | — | 1 | 2 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 1 | — | — | — | — | 1 |
| Hodgkin disease | D006689 | — | C81 | 1 | — | — | — | — | 1 |
| B-cell lymphoma marginal zone | D018442 | — | C88.4 | 1 | — | — | — | — | 1 |
| Adenocarcinoma | D000230 | — | — | 1 | — | — | — | — | 1 |
| Mycosis fungoides | D009182 | — | C84.0 | 1 | — | — | — | — | 1 |
| T-cell lymphoma cutaneous | D016410 | — | C84.A | 1 | — | — | — | — | 1 |
| Insulin resistance | D007333 | EFO_0002614 | E88.819 | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | — | — | — | — | 3 | 3 |
| Male infertility | D007248 | EFO_0004248 | N46 | — | — | — | — | 2 | 2 |
| Arthritis | D001168 | EFO_0005856 | M05-M14 | — | — | — | — | 2 | 2 |
| Chronic pain | D059350 | — | — | — | — | — | — | 2 | 2 |
| Sarcopenia | D055948 | EFO_1000653 | M62.84 | — | — | — | — | 2 | 2 |
| Body weight | D001835 | EFO_0004338 | — | — | — | — | — | 1 | 1 |
| Body weight changes | D001836 | — | — | — | — | — | — | 1 | 1 |
| Myalgia | D063806 | — | M79.1 | — | — | — | — | 1 | 1 |
| Vitamin d deficiency | D014808 | EFO_0003762 | E55 | — | — | — | — | 1 | 1 |
| Inguinal hernia | D006552 | HP_0000023 | K40 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Glucosamine |
| INN | glucosamine |
| Description | 2-amino-2-deoxy-D-glucopyranose is a D-glucosamine whose structure comprises D-glucopyranose having an amino substituent at position 2. It has a role as an Escherichia coli metabolite, a mouse metabolite and a geroprotector. It is functionally related to a D-glucopyranose. It is a conjugate base of a 2-ammonio-2-deoxy-D-glucopyranose. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O |
Identifiers
| PDB | — |
| CAS-ID | 3416-24-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL493287 |
| ChEBI ID | 47977 |
| PubChem CID | 439213 |
| DrugBank | DB01296 |
| UNII ID | N08U5BOQ1K (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
P2RY14
P2RY14
Organism
Homo sapiens
Gene name
P2RY14
Gene synonyms
GPR105, KIAA0001
NCBI Gene ID
Protein name
P2Y purinoceptor 14
Protein synonyms
G protein coupled receptor for UDP-glucose, G-protein coupled receptor 105, P2Y(14) receptor, P2Y14 receptor, purinergic receptor P2Y, G-protein coupled, 14, UDP-glucose receptor
Uniprot ID
Mouse ortholog
P2ry14 (140795)
P2Y purinoceptor 14 (Q9ESG6)
Variants
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Financial
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Estimated US medical usage
Glucosamine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Trends
PubMed Central
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Additional graphs summarizing 57,423 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,859 adverse events reported
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