Gliclazide
Gliclazide is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
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Clinical
Clinical Trials
85 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 3 | 2 | 13 | 27 | 24 | 68 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | — | 9 | 10 | 8 | 27 |
| Diabetic nephropathies | D003928 | EFO_0000401 | — | — | — | — | 2 | 1 | 3 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | — | — | 2 | — | 2 |
| Atherosclerosis | D050197 | EFO_0003914 | I25.1 | — | — | — | 1 | — | 1 |
| Non-alcoholic fatty liver disease | D065626 | EFO_0003095 | K75.81 | — | — | — | 1 | — | 1 |
| Hypoglycemia | D007003 | — | E16.2 | — | — | — | 1 | — | 1 |
| Metabolic bone diseases | D001851 | — | — | — | — | — | 1 | — | 1 |
| Osteoporosis | D010024 | EFO_0003882 | M81.0 | — | — | — | 1 | — | 1 |
| Menopause | D008593 | EFO_0003922 | N95 | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Vascular diseases | D014652 | EFO_0004264 | I77 | — | — | 1 | — | 1 | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hyperglycemia | D006943 | — | R73.9 | — | 1 | — | — | 1 | 2 |
| Nausea | D009325 | — | R11.0 | — | 1 | — | — | — | 1 |
| Diarrhea | D003967 | — | R19.7 | — | 1 | — | — | — | 1 |
| Immunoglobulin light-chain amyloidosis | D000075363 | — | — | — | 1 | — | — | — | 1 |
| Gastrointestinal hemorrhage | D006471 | — | K92.2 | — | 1 | — | — | — | 1 |
| Lymphadenopathy | D000072281 | — | R59.1 | — | 1 | — | — | — | 1 |
| Constipation | D003248 | — | K59.0 | — | 1 | — | — | — | 1 |
| Purpura | D011693 | HP_0000979 | D69.2 | — | 1 | — | — | — | 1 |
| Hepatomegaly | D006529 | — | R16.0 | — | 1 | — | — | — | 1 |
| Macroglossia | D008260 | — | K14.8 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Insulin resistance | D007333 | EFO_0002614 | E88.819 | 1 | — | — | — | 3 | 4 |
| Healthy volunteers/patients | — | — | — | 3 | — | — | — | — | 3 |
| Diabetic retinopathy | D003930 | EFO_0003770 | — | 1 | — | — | — | — | 1 |
| Epilepsy | D004827 | EFO_0000474 | G40.9 | 1 | — | — | — | — | 1 |
| Chronic renal insufficiency | D051436 | — | N18 | 1 | — | — | — | — | 1 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 1 | — | — | — | — | 1 |
| Renal insufficiency | D051437 | — | N19 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cognitive dysfunction | D060825 | — | G31.84 | — | — | — | — | 2 | 2 |
| Pancreatitis | D010195 | EFO_0000278 | K85 | — | — | — | — | 1 | 1 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | — | — | — | — | 1 | 1 |
| Heart failure | D006333 | EFO_0003144 | I50 | — | — | — | — | 1 | 1 |
| Neoplasms | D009369 | — | C80 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Gliclazide |
| INN | gliclazide |
| Description | Gliclazide is a N-sulfonylurea. It has a role as a hypoglycemic agent, a radical scavenger and an insulin secretagogue. |
| Classification | Small molecule |
| Drug class | antidiabetics |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1ccc(S(=O)(=O)NC(=O)NN2CC3CCCC3C2)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 21187-98-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL427216 |
| ChEBI ID | 31654 |
| PubChem CID | 3475 |
| DrugBank | DB01120 |
| UNII ID | G4PX8C4HKV (ChemIDplus, GSRS) |
Target
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Trends
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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7,823 adverse events reported
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