Gimeracil
Teysuno (gimeracil) is a small molecule pharmaceutical. Gimeracil was first approved as Teysuno on 2011-03-14. It has been approved in Europe to treat stomach neoplasms.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| neoplasms | D009369 |
| digestive system diseases | D004066 |
Trade Name
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Drug Products
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New Drug Application (NDA)
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Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Agency Specific
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Clinical
Clinical Trials
125 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | 4 | 41 | 19 | 1 | 1 | 60 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 1 | 8 | — | 2 | — | 11 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Adenocarcinoma | D000230 | — | — | 2 | 10 | 3 | — | 1 | 15 |
| Carcinoma | D002277 | — | C80.0 | 2 | 7 | 2 | — | — | 11 |
| Esophageal neoplasms | D004938 | — | C15 | 1 | 6 | 2 | — | 1 | 9 |
| Colorectal neoplasms | D015179 | — | — | 1 | 5 | 3 | — | — | 8 |
| Squamous cell carcinoma | D002294 | — | — | — | 6 | 1 | — | — | 7 |
| Neoadjuvant therapy | D020360 | — | — | — | 4 | 1 | — | — | 5 |
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | 3 | 1 | — | — | 5 |
| Esophageal squamous cell carcinoma | D000077277 | — | — | — | 4 | 1 | — | — | 5 |
| Colonic neoplasms | D003110 | — | C18 | — | 3 | 1 | — | — | 4 |
| Head and neck neoplasms | D006258 | — | — | — | 3 | 1 | — | — | 4 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 3 | 5 | — | — | 1 | 9 |
| Rectal neoplasms | D012004 | — | — | 1 | 3 | — | — | 1 | 5 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 2 | 1 | — | — | — | 3 |
| Gastrointestinal neoplasms | D005770 | — | C26.9 | — | 2 | — | — | — | 2 |
| Pancreatic ductal carcinoma | D021441 | — | — | 1 | 1 | — | — | — | 2 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | — | 2 | — | — | — | 2 |
| Squamous cell carcinoma of head and neck | D000077195 | — | — | — | 2 | — | — | — | 2 |
| Immunotherapy | D007167 | — | — | — | 2 | — | — | — | 2 |
| Bile duct neoplasms | D001650 | — | — | — | 1 | — | — | — | 1 |
| Unknown primary neoplasms | D009382 | — | — | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hepatocellular carcinoma | D006528 | — | C22.0 | 2 | — | — | — | — | 2 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cardiotoxicity | D066126 | EFO_1001482 | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Gimeracil |
| INN | gimeracil |
| Description | Tegafur/gimeracil/oteracil, sold under the brand name Teysuno among others is a fixed-dose combination medication used for the treatment of advanced gastric cancer when used in combination with cisplatin, and also for the treatment of head and neck cancer, colorectal cancer, non–small-cell lung, breast, pancreatic, and biliary tract cancers.: 213 
|
| Classification | Small molecule |
| Drug class | uracil type antineoplastics |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Oc1cc(O)c(Cl)cn1 |
Identifiers
| PDB | — |
| CAS-ID | 103766-25-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1730601 |
| ChEBI ID | — |
| PubChem CID | 54715158 |
| DrugBank | — |
| UNII ID | UA8SE1325T (ChemIDplus, GSRS) |
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Safety
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Adverse Events
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2,325 adverse events reported
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