Gevokizumab
Gevokizumab is an antibody pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against interleukin-1 beta.
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Study first post date
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Commercial
No data
Clinical
Clinical Trials
26 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Uveitis | D014605 | HP_0000554 | H20.9 | — | — | 6 | — | — | 6 |
| Pyoderma gangrenosum | D017511 | EFO_0006835 | L88 | — | 1 | 3 | — | — | 4 |
| Pyoderma | D011711 | HP_0000999 | L08.0 | — | 1 | 3 | — | — | 4 |
| Behcet syndrome | D001528 | EFO_0003780 | M35.2 | 1 | 1 | 2 | — | — | 3 |
| Anterior uveitis | D014606 | EFO_1000811 | — | — | — | 2 | — | — | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | 2 | 5 | — | — | — | 6 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 2 | 3 | — | — | — | 4 |
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | — | 2 | — | — | 1 | 3 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | — | 2 | — | — | — | 2 |
| Ear diseases | D004427 | EFO_1001455 | H93.9 | — | 1 | — | — | — | 1 |
| Labyrinth diseases | D007759 | — | — | — | 1 | — | — | — | 1 |
| Labyrinthitis | D007762 | — | H83.0 | — | 1 | — | — | — | 1 |
| Scleritis | D015423 | HP_0100534 | H15.0 | 1 | 1 | — | — | — | 1 |
| Acne vulgaris | D000152 | EFO_0003894 | L70 | — | 1 | — | — | — | 1 |
| Eosinophilia | D004802 | HP_0001880 | D72.1 | 1 | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Renal cell carcinoma | D002292 | EFO_0000376 | — | 1 | — | — | — | — | 1 |
| Carcinoma | D002277 | — | C80.0 | 1 | — | — | — | — | 1 |
| Colorectal neoplasms | D015179 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Gevokizumab |
| INN | gevokizumab |
| Description | Gevokizumab (humanized mab) |
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | >4G6M:H|heavy chain of gevokizumab antibody binding fragment
QVQLQESGPGLVKPSQTLSLTCSFSGFSLSTSGMGVGWIRQPSGKGLEWLAHIWWDGDESYNPSLKSRLTISKDTSKNQV
SLKITSVTAADTAVYFCARNRYDPPWFVDWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS
WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEP
>4G6M:L|light chain of gevokizumab antibody binding fragment
DIQMTQSTSSLSASVGDRVTITCRASQDISNYLSWYQQKPGKAVKLLIYYTSKLHSGVPSRFSGSGSGTDYTLTISSLQQ
EDFATYFCLQGKMLPWTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ
ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE |
Identifiers
| PDB | 4G6K, 4G6M |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL1743026 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | QX3JU54GYQ (ChemIDplus, GSRS) |
Target
Alternate
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Variants
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Financial
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Trends
PubMed Central
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Additional graphs summarizing 563 documents
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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12 adverse events reported
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