Genistein
Genistein is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target steroid hormone receptor ERR2, estrogen receptor beta, steroid hormone receptor ERR1, cystic fibrosis transmembrane conductance regulator, short transient receptor potential channel 5, and estrogen-related receptor gamma.
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Commercial
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Clinical
Clinical Trials
93 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
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Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Metabolic bone diseases | D001851 | — | — | — | — | — | — | 1 | 1 |
| Menopause | D008593 | EFO_0003922 | N95 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Genistein |
| INN | genistein |
| Description | Genistein is a 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties. It has a role as an antineoplastic agent, a tyrosine kinase inhibitor, an EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor, a phytoestrogen, a plant metabolite, a geroprotector and a human urinary metabolite. It is a conjugate acid of a genistein(1-). |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=c1c(-c2ccc(O)cc2)coc2cc(O)cc(O)c12 |
Identifiers
| PDB | — |
| CAS-ID | 446-72-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL44 |
| ChEBI ID | 28088 |
| PubChem CID | 5280961 |
| DrugBank | DB01645 |
| UNII ID | DH2M523P0H (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
ESR2
ESR2
ESRRB
ESRRB
Organism
Homo sapiens
Gene name
ESR2
Gene synonyms
ESTRB, NR3A2
NCBI Gene ID
Protein name
estrogen receptor beta
Protein synonyms
estrogen receptor beta 2, estrogen receptor beta 4, Nuclear receptor subfamily 3 group A member 2, oestrogen receptor beta
Uniprot ID
Mouse ortholog
Esr2 (13983)
estrogen receptor beta (O08537)
Variants
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Trends
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Safety
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Adverse Events
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