Genistein
Genistein is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target steroid hormone receptor ERR2, estrogen receptor beta, steroid hormone receptor ERR1, cystic fibrosis transmembrane conductance regulator, short transient receptor potential channel 5, and estrogen-related receptor gamma.
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Clinical Trials
97 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | 1 | 1 | 1 | 1 | 4 |
| Motor activity | D009043 | EFO_0003940 | — | — | — | — | 1 | 2 | 3 |
| Post-acute covid-19 syndrome | D000094024 | — | — | — | 1 | — | 1 | — | 2 |
| Irritable bowel syndrome | D043183 | EFO_0000555 | K58 | — | — | — | 1 | — | 1 |
| Overweight | D050177 | — | E66.3 | — | — | — | 1 | — | 1 |
| Pelvic floor disorders | D059952 | — | — | — | — | — | 1 | — | 1 |
| Sepsis | D018805 | EFO_0001420 | A41.9 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Prostatic neoplasms | D011471 | — | C61 | 3 | 8 | 1 | — | 2 | 12 |
| Osteoporosis | D010024 | EFO_0003882 | M81.0 | 1 | 3 | 3 | — | 3 | 8 |
| Menopause | D008593 | EFO_0003922 | N95 | — | 3 | 2 | — | 3 | 7 |
| Metabolic bone diseases | D001851 | — | — | 1 | 1 | 1 | — | 2 | 4 |
| Metabolic syndrome | D024821 | EFO_0000195 | E88.810 | — | 2 | 2 | — | 1 | 3 |
| Glucose intolerance | D018149 | HP_0000833 | R73.03 | — | 2 | 2 | — | — | 2 |
| Meningitis | D008581 | EFO_0000584 | G03 | — | — | 1 | — | — | 1 |
| Thrombosis | D013927 | — | — | — | — | 1 | — | — | 1 |
| Thrombophilia | D019851 | — | D68.59 | — | — | 1 | — | — | 1 |
| Coronary artery disease | D003324 | — | I25.1 | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 2 | 3 | — | — | 1 | 5 |
| Neoplasms | D009369 | — | C80 | 3 | 3 | — | — | — | 4 |
| Non-small-cell lung carcinoma | D002289 | — | — | 3 | 3 | — | — | — | 3 |
| Lung neoplasms | D008175 | — | C34.90 | 3 | 3 | — | — | — | 3 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 1 | 3 | — | — | — | 3 |
| Leukemia | D007938 | — | C95 | 1 | 1 | — | — | — | 2 |
| Lymphoid leukemia | D007945 | — | C91 | 1 | 1 | — | — | — | 2 |
| Adenocarcinoma | D000230 | — | — | 1 | 2 | — | — | — | 2 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 1 | 1 | — | — | — | 2 |
| Lymphoma | D008223 | — | C85.9 | 1 | 1 | — | — | — | 2 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Acute radiation syndrome | D054508 | — | — | 3 | — | — | — | — | 3 |
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | 2 | 3 |
| Infections | D007239 | EFO_0000544 | — | 2 | — | — | — | — | 2 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 2 | — | — | — | — | 2 |
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | 2 | — | — | — | — | 2 |
| Syndrome | D013577 | — | — | 1 | — | — | — | 1 | 2 |
| Cutaneous malignant melanoma | D000096142 | — | — | 1 | — | — | — | — | 1 |
| Head and neck neoplasms | D006258 | — | — | 1 | — | — | — | — | 1 |
| Radiation injuries | D011832 | — | T66 | 1 | — | — | — | — | 1 |
| Endometrial neoplasms | D016889 | EFO_0004230 | — | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | — | 3 | 3 |
| Inflammation | D007249 | MP_0001845 | — | — | — | — | — | 3 | 3 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | — | 2 | 2 |
| Squamous cell carcinoma of head and neck | D000077195 | — | — | — | — | — | — | 2 | 2 |
| Diet therapy | D004035 | — | — | — | — | — | — | 1 | 1 |
| Insulin resistance | D007333 | EFO_0002614 | E88.819 | — | — | — | — | 1 | 1 |
| Weight loss | D015431 | — | — | — | — | — | — | 1 | 1 |
| Blood pressure | D001794 | EFO_0004325 | — | — | — | — | — | 1 | 1 |
| Male breast neoplasms | D018567 | — | — | — | — | — | — | 1 | 1 |
| Disease progression | D018450 | — | — | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Genistein |
| INN | genistein |
| Description | Genistein is a 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties. It has a role as an antineoplastic agent, a tyrosine kinase inhibitor, an EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor, a phytoestrogen, a plant metabolite, a geroprotector and a human urinary metabolite. It is a conjugate acid of a genistein(1-). |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=c1c(-c2ccc(O)cc2)coc2cc(O)cc(O)c12 |
Identifiers
| PDB | — |
| CAS-ID | 446-72-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL44 |
| ChEBI ID | 28088 |
| PubChem CID | 5280961 |
| DrugBank | DB01645 |
| UNII ID | DH2M523P0H (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
ESR2
ESR2
ESRRB
ESRRB
Organism
Homo sapiens
Gene name
ESR2
Gene synonyms
ESTRB, NR3A2
NCBI Gene ID
Protein name
estrogen receptor beta
Protein synonyms
estrogen receptor beta 2, estrogen receptor beta 4, Nuclear receptor subfamily 3 group A member 2, oestrogen receptor beta
Uniprot ID
Mouse ortholog
Esr2 (13983)
estrogen receptor beta (O08537)
Variants
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Financial
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Trends
PubMed Central
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Safety
Black-box Warning
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Adverse Events
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