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Drug ReportsFurosemide
Furosemide
Furoscix, Furosemide, Lasix (furosemide) is a small molecule pharmaceutical. Furosemide was first approved as Furosemide on 1982-01-01. It is used to treat ascites, chronic kidney failure, edema, heart failure, and hypertension amongst others in the USA. The pharmaceutical is active against solute carrier family 12 member 1. In addition, it is known to target solute carrier family 12 member 2 and G-protein coupled receptor 35.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
digestive system diseasesD004066
respiratory tract diseasesD012140
urogenital diseasesD000091642
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Furoscix, Furosemide, Lasix (discontinued: Furosemide, Lasix)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Furosemide
Tradename
Company
Number
Date
Products
FUROSEMIDEEpic PharmaN-018569 RX1982-01-01
3 products
FUROSEMIDEFresenius KabiN-018902 RX1984-05-22
1 products
FUROSEMIDEHikma PharmaceuticalsN-018267 RX1982-01-01
1 products
FUROSEMIDEHikma PharmaceuticalsN-018823 RX1983-11-10
2 products
FUROSEMIDEHospiraN-018667 RX1982-05-28
1 products
FUROSCIXscPharmaceuticalsN-209988 RX2022-10-07
1 products, RLD, RS
LASIXValidus PharmaceuticalsN-016273 RX1982-01-01
3 products, RLD, RS
Show 18 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
14-panel toxicology medicated collection systemANDA2022-03-29
active-medicated specimen collection kitANDA2014-03-20
diascreen 12-panel medicated collection systemANDA2022-02-25
furoscixNew Drug Application2024-08-15
furosemideNew Drug Application2024-10-29
lasixNew Drug Application2023-02-13
rx-specimen collection kitANDA2018-02-22
toxicology medicated collection systemANDA2022-04-05
toxycology medicated collection systemANDA2022-02-25
udsx medicated systemunapproved drug other2024-09-10
Show 1 more
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Furosemide, Furoscix, Scpharmaceuticals
98840392034-04-03U-3462
102720642034-04-03DP
114330442034-04-03U-3462
ATC Codes
C: Cardiovascular system drugs
— C03: Diuretics
— C03C: High-ceiling diuretics
— C03CA: Sulfonamides, high-ceiling diuretics, plain
— C03CA01: Furosemide
— C03CB: Sulfonamides and potassium in combination, high-ceiling diruetics, excluding thiazides
— C03CB01: Furosemide and potassium
— C03E: Diuretics and potassium-sparing agents in combination
— C03EB: High-ceiling diuretics and potassium-sparing agents
— C03EB01: Furosemide and potassium-sparing agents
HCPCS
Code
Description
J1940
Injection, furosemide, up to 20 mg
Clinical
Clinical Trials
376 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Heart failureD006333HP_0001635I501430313737136
Renal insufficiencyD051437HP_0000083N193456825
HypertensionD006973EFO_0000537I1013471024
Acute kidney injuryD058186HP_0001919N1713351424
Kidney diseasesD007674EFO_0003086N081337518
Chronic renal insufficiencyD051436—N181227214
Critical illnessD016638———221812
Iron overloadD019190——1124311
Wounds and injuriesD014947—T14.8—2—2711
Liver cirrhosisD008103EFO_0001422K74.0—213510
Show 36 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
DyspneaD004417HP_0002094R06.0434——8
WartsD014860—B07—12—25
Covid-19D000086382———11—34
SyndromeD013577———11—24
Hepatocellular carcinomaD006528—C22.0——3—14
Kidney calculiD007669EFO_0004253N20——2—24
BronchiolitisD001988HP_0011950—111——3
HypernatremiaD006955HP_0003228E87.0——1—23
Respiratory insufficiencyD012131HP_0002093J96.9—12—13
NephrolithiasisD053040—N20.0——2—13
Show 44 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients———181——321
NeoplasmsD009369—C8042———5
Acute lung injuryD055371EFO_0004610——1——34
SepsisD018805HP_0100806A41.9—1——34
LeukemiaD007938—C9521——13
InflammationD007249MP_0001845—11——23
Ovarian neoplasmsD010051EFO_0003893C5621———2
Myelodysplastic syndromesD009190—D4621———2
Multiple myelomaD009101—C90.021———2
LymphomaD008223—C85.921———2
Show 22 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
DehydrationD003681—E86.01———45
CardiomyopathiesD009202EFO_0000318I422———13
HypersensitivityD006967HP_0012393T78.401———12
Drug interactionsD004347——2————2
StrokeD020521EFO_0000712I63.91————1
Food-drug interactionsD018565——1————1
Pancreatic neoplasmsD010190EFO_0003860C251————1
Stomach neoplasmsD013274EFO_0003897C161————1
Peritoneal neoplasmsD010534——1————1
Crush injuriesD000071576—T14.81————1
Show 14 more
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Respiratory distress syndromeD012128EFO_1000637J80————33
Newborn respiratory distress syndromeD012127—P22————33
Septic shockD012772—A48.3————33
HemorrhageD006470MP_0001914R58————22
Pulmonary arterial hypertensionD000081029——————22
ObesityD009765EFO_0001073E66.9————22
Coronary artery diseaseD003324—I25.1————22
Myocardial ischemiaD017202EFO_1001375I20-I25————22
Fluid therapyD005440——————22
ShockD012769—R57.1————22
Show 75 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameFurosemide
INNfurosemide
Description
Furosemide is a chlorobenzoic acid that is 4-chlorobenzoic acid substituted by a (furan-2-ylmethyl)amino and a sulfamoyl group at position 2 and 5 respectively. It is a diuretic used in the treatment of congestive heart failure. It has a role as a xenobiotic, an environmental contaminant and a loop diuretic. It is a sulfonamide, a chlorobenzoic acid and a member of furans.
Classification
Small molecule
Drug classdiuretics (furosemide type)
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
NS(=O)(=O)c1cc(C(=O)O)c(NCc2ccco2)cc1Cl
Identifiers
PDB—
CAS-ID54-31-9
RxCUI—
ChEMBL IDCHEMBL35
ChEBI ID47426
PubChem CID3440
DrugBankDB00695
UNII ID7LXU5N7ZO5 (ChemIDplus, GSRS)
Target
Agency Approved
SLC12A1
SLC12A1
Organism
Homo sapiens
Gene name
SLC12A1
Gene synonyms
NKCC2
NCBI Gene ID
Protein name
solute carrier family 12 member 1
Protein synonyms
bumetanide-sensitive cotransporter type 1, Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2, Kidney-specific Na-K-Cl symporter, Na-K-2Cl cotransporter, Na-K-2Cl cotransporter 2, solute carrier family 12 (sodium/potassium/chloride transporter), member 1, solute carrier family 12 (sodium/potassium/chloride transporters), member 1
Uniprot ID
Mouse ortholog
Slc12a1 (20495)
solute carrier family 12 member 1 (P55014)
Alternate
CISD1
CISD1
Organism
Homo sapiens
Gene name
CISD1
Gene synonyms
C10orf70, ZCD1
NCBI Gene ID
Protein name
CDGSH iron-sulfur domain-containing protein 1
Protein synonyms
Cysteine transaminase CISD1, MitoNEET, zinc finger CDGSH-type domain 1
Uniprot ID
Mouse ortholog
Cisd1 (52637)
CDGSH iron-sulfur domain-containing protein 1 (Q91WS0)
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
No data
Estimated US medical usage
Furosemide
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 37,304 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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63,363 adverse events reported
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