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Drug ReportsFurosemide
Furosemide
Furoscix, Furosemide, Lasix (furosemide) is a small molecule pharmaceutical. Furosemide was first approved as Furosemide on 1982-01-01. It is used to treat ascites, chronic kidney failure, edema, heart failure, and hypertension amongst others in the USA. The pharmaceutical is active against solute carrier family 12 member 1. In addition, it is known to target solute carrier family 12 member 2 and G-protein coupled receptor 35.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
digestive system diseasesD004066
respiratory tract diseasesD012140
urogenital diseasesD000091642
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Furoscix, Furosemide, Lasix (discontinued: Furosemide, Lasix)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Furosemide
Tradename
Company
Number
Date
Products
FUROSEMIDEEpic PharmaN-018569 RX1982-01-01
3 products
FUROSEMIDEFresenius KabiN-018902 RX1984-05-22
1 products
FUROSEMIDEHikma PharmaceuticalsN-018267 RX1982-01-01
1 products
FUROSEMIDEHikma PharmaceuticalsN-018823 RX1983-11-10
2 products
FUROSEMIDEHospiraN-018667 RX1982-05-28
1 products
FUROSCIXscPharmaceuticalsN-209988 RX2022-10-07
1 products, RLD, RS
LASIXValidus PharmaceuticalsN-016273 RX1982-01-01
3 products, RLD, RS
Show 18 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
14-panel toxicology medicated collection systemANDA2022-03-29
diascreen 12-panel medicated collection systemANDA2022-02-25
furoscixNew Drug Application2025-08-12
furosemideANDA2025-10-02
lasixNew Drug Application2025-09-30
rx-specimen collection kitANDA2018-02-22
toxicology medicated collection systemANDA2022-04-05
toxycology medicated collection systemANDA2022-02-25
udsx medicated systemunapproved drug other2025-06-12
udsxmp medicated systemunapproved drug other2025-06-12
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
heart failureEFO_0003144D006333I50
hypertensionEFO_0000537D006973I10
chronic kidney failureEFO_0003884D007676N18.6
liver cirrhosisEFO_0001422D008103K74.0
nephrotic syndromeEFO_0004255D009404N04
edema—D004487R60.9
ascites—D001201R18
pulmonary edemaEFO_1001134D011654J81
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Furosemide, Furoscix, Scpharmaceuticals
98840392034-04-03U-3462
102720642034-04-03DP
114330442034-04-03U-3462
ATC Codes
C: Cardiovascular system drugs
— C03: Diuretics
— C03C: High-ceiling diuretics
— C03CA: Sulfonamides, high-ceiling diuretics, plain
— C03CA01: Furosemide
— C03CB: Sulfonamides and potassium in combination, high-ceiling diruetics, excluding thiazides
— C03CB01: Furosemide and potassium
— C03E: Diuretics and potassium-sparing agents in combination
— C03EB: High-ceiling diuretics and potassium-sparing agents
— C03EB01: Furosemide and potassium-sparing agents
HCPCS
Code
Description
J1940
Injection, furosemide, up to 20 mg
Clinical
Clinical Trials
402 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Renal insufficiencyD051437—N191————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameFurosemide
INNfurosemide
Description
Furosemide is a chlorobenzoic acid that is 4-chlorobenzoic acid substituted by a (furan-2-ylmethyl)amino and a sulfamoyl group at position 2 and 5 respectively. It is a diuretic used in the treatment of congestive heart failure. It has a role as a xenobiotic, an environmental contaminant and a loop diuretic. It is a sulfonamide, a chlorobenzoic acid and a member of furans.
Classification
Small molecule
Drug classdiuretics (furosemide type)
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
NS(=O)(=O)c1cc(C(=O)O)c(NCc2ccco2)cc1Cl
Identifiers
PDB—
CAS-ID54-31-9
RxCUI—
ChEMBL IDCHEMBL35
ChEBI ID47426
PubChem CID3440
DrugBankDB00695
UNII ID7LXU5N7ZO5 (ChemIDplus, GSRS)
Target
Agency Approved
SLC12A1
SLC12A1
Organism
Homo sapiens
Gene name
SLC12A1
Gene synonyms
NKCC2
NCBI Gene ID
6557
Protein name
solute carrier family 12 member 1
Protein synonyms
bumetanide-sensitive cotransporter type 1, Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2, Kidney-specific Na-K-Cl symporter, Na-K-2Cl cotransporter, Na-K-2Cl cotransporter 2, solute carrier family 12 (sodium/potassium/chloride transporter), member 1, solute carrier family 12 (sodium/potassium/chloride transporters), member 1
Uniprot ID
Q13621
Mouse ortholog
Slc12a1 (20495)
solute carrier family 12 member 1 (P55014)
Alternate
CISD1
CISD1
Organism
Homo sapiens
Gene name
CISD1
Gene synonyms
C10orf70, ZCD1
NCBI Gene ID
55847
Protein name
CDGSH iron-sulfur domain-containing protein 1
Protein synonyms
Cysteine transaminase CISD1, MitoNEET, zinc finger CDGSH-type domain 1
Uniprot ID
Q9NZ45
Mouse ortholog
Cisd1 (52637)
CDGSH iron-sulfur domain-containing protein 1 (Q91WS0)
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
No data
Estimated US medical usage
Furosemide
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 41,279 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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70,403 adverse events reported
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