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Drug ReportsFluvoxamine
Fluvoxamine
Fluvoxamine, Luvox (fluvoxamine) is a small molecule pharmaceutical. Fluvoxamine was first approved as Luvox on 1994-12-05. It is used to treat depressive disorder, obsessive-compulsive disorder, and panic disorder in the USA. The pharmaceutical is active against sodium-dependent serotonin transporter. In addition, it is known to target sigma non-opioid intracellular receptor 1.
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FDA approval date
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Study first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
mental disordersD001523
Trade Name
FDA
EMA
Fluvoxamine, Luvox (discontinued: Fluvoxamine, Luvox)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Fluvoxamine maleate
Tradename
Company
Number
Date
Products
LUVOXANI PharmaceuticalsN-021519 RX2007-12-20
3 products, RLD
Show 2 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
fluvoxamine maleateANDA2025-03-05
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N06: Psychoanaleptics
— N06A: Antidepressants
— N06AB: Selective serotonin reuptake inhibitors
— N06AB08: Fluvoxamine
HCPCS
No data
Clinical
Clinical Trials
98 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients———1————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameFluvoxamine
INNfluvoxamine
Description
Fluvoxamine is an oxime O-ether that is benzene substituted by a (1E)-N-(2-aminoethoxy)-5-methoxypentanimidoyl group at position 1 and a trifluoromethyl group at position 4. It is a selective serotonin reuptake inhibitor that is used for the treatment of obsessive-compulsive disorder. It has a role as an antidepressant, a serotonin uptake inhibitor and an anxiolytic drug. It is a 5-methoxyvalerophenone O-(2-aminoethyl)oxime and a member of (trifluoromethyl)benzenes. It is functionally related to a (trifluoromethyl)benzene.
Classification
Small molecule
Drug classSelective serotonin reuptake inhibitor (SSRI)
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
COCCCC/C(=N\OCCN)c1ccc(C(F)(F)F)cc1
Identifiers
PDB—
CAS-ID54739-18-3
RxCUI—
ChEMBL IDCHEMBL814
ChEBI ID5138
PubChem CID5324346
DrugBankDB00176
UNII IDO4L1XPO44W (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
SIGMAR1
SIGMAR1
Organism
Homo sapiens
Gene name
SIGMAR1
Gene synonyms
OPRS1, SRBP
NCBI Gene ID
Protein name
sigma non-opioid intracellular receptor 1
Protein synonyms
Aging-associated gene 8 protein, hSigmaR1, SIG-1R, Sigma 1-type opioid receptor, Sigma1-receptor, Sigma1R, SR-BP, SR31747 binding protein 1, SR31747-binding protein
Uniprot ID
Mouse ortholog
Sigmar1 (18391)
sigma non-opioid intracellular receptor 1 (O55242)
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
Luvox – Jazz Pharmaceuticals
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Estimated US medical usage
Fluvoxamine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 10,305 documents
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Safety
Black-box Warning
Black-box warning for: Fluvoxamine maleate
Adverse Events
Top Adverse Reactions
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3,592 adverse events reported
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