Fluvoxamine
Fluvoxamine, Luvox (fluvoxamine) is a small molecule pharmaceutical. Fluvoxamine was first approved as Luvox on 1994-12-05. It is used to treat depressive disorder, obsessive-compulsive disorder, and panic disorder in the USA. The pharmaceutical is active against sodium-dependent serotonin transporter. In addition, it is known to target sigma non-opioid intracellular receptor 1.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| mental disorders | D001523 |
Trade Name
FDA
EMA
Fluvoxamine, Luvox (discontinued: Fluvoxamine, Luvox)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Fluvoxamine maleate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| LUVOX | ANI Pharmaceuticals | N-021519 RX | 2007-12-20 | 3 products, RLD |
Show 2 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| fluvoxamine maleate | ANDA | 2024-12-24 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
97 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Depressive disorder | D003866 | EFO_1002014 | F32.A | — | 3 | — | 11 | 11 | 25 |
| Depression | D003863 | — | F33.9 | 1 | 1 | 1 | 7 | 12 | 22 |
| Obsessive-compulsive disorder | D009771 | EFO_0004242 | F42 | — | 1 | 3 | 8 | 6 | 18 |
| Compulsive personality disorder | D003193 | — | F60.5 | — | 1 | 2 | 8 | 6 | 17 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | — | 1 | — | 9 | 4 | 14 |
| Covid-19 | D000086382 | — | — | — | 4 | 7 | 1 | — | 12 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | — | 1 | 1 | 2 | 4 |
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | — | — | 2 | 1 | 1 | 4 |
| Treatment-resistant depressive disorder | D061218 | — | — | — | — | — | 2 | 1 | 3 |
| Atrophy | D001284 | — | — | — | — | — | 1 | — | 1 |
Show 6 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Severe acute respiratory syndrome | D045169 | EFO_0000694 | J12.81 | — | 1 | 2 | — | — | 3 |
| Post-acute covid-19 syndrome | D000094024 | — | — | — | 2 | 2 | — | — | 3 |
| Coronavirus | D017934 | — | — | — | 1 | 1 | — | — | 2 |
| Separation anxiety | D001010 | EFO_1001916 | — | — | — | 1 | — | 1 | 2 |
| Social phobia | D000072861 | EFO_1001917 | F40.1 | — | — | 1 | — | 1 | 2 |
| Severe acute respiratory syndrome-related coronavirus | D045473 | NCBITaxon_227859 | — | — | — | 1 | — | — | 1 |
| Dementia | D003704 | EFO_0003862 | F03 | — | — | 1 | — | — | 1 |
| Psychophysiologic disorders | D011602 | — | F45.9 | — | — | 1 | — | — | 1 |
| Somatoform disorders | D013001 | — | F45 | — | — | 1 | — | — | 1 |
| Infections | D007239 | EFO_0000544 | — | — | — | 1 | — | — | 1 |
Show 4 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Coronavirus infections | D018352 | EFO_0007224 | B34.2 | — | 1 | — | — | — | 1 |
| Sars-cov-2 | D000086402 | — | — | — | 1 | — | — | — | 1 |
| Olfaction disorders | D000857 | HP_0000458 | R43.0 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 15 | — | — | — | — | 15 |
| Drug interactions | D004347 | — | — | 2 | — | — | — | 1 | 3 |
| Neoplasms | D009369 | — | C80 | 2 | — | — | — | — | 2 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | — | — | — | — | 1 |
| Atopic dermatitis | D003876 | EFO_0000274 | L20 | 1 | — | — | — | — | 1 |
| Dermatitis | D003872 | HP_0011123 | L30.9 | 1 | — | — | — | — | 1 |
| Non-alcoholic fatty liver disease | D065626 | EFO_0003095 | K75.81 | 1 | — | — | — | — | 1 |
| Weight gain | D015430 | HP_0004324 | — | 1 | — | — | — | — | 1 |
| Fatty liver | D005234 | EFO_0003934 | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Taste disorders | D013651 | — | — | — | — | — | — | 3 | 3 |
| Wounds and injuries | D014947 | — | T14.8 | — | — | — | — | 2 | 2 |
| Cognitive dysfunction | D060825 | HP_0001268 | G31.84 | — | — | — | — | 2 | 2 |
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | — | — | — | 1 | 1 |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | — | — | — | — | 1 | 1 |
| Pain | D010146 | EFO_0003843 | R52 | — | — | — | — | 1 | 1 |
| Substance-related disorders | D019966 | EFO_0003890 | F13 | — | — | — | — | 1 | 1 |
| Chronic disease | D002908 | — | — | — | — | — | — | 1 | 1 |
| Brain injuries | D001930 | — | S06.9 | — | — | — | — | 1 | 1 |
| Alcohol-related disorders | D019973 | — | F10 | — | — | — | — | 1 | 1 |
Show 12 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Fluvoxamine |
| INN | fluvoxamine |
| Description | Fluvoxamine is an oxime O-ether that is benzene substituted by a (1E)-N-(2-aminoethoxy)-5-methoxypentanimidoyl group at position 1 and a trifluoromethyl group at position 4. It is a selective serotonin reuptake inhibitor that is used for the treatment of obsessive-compulsive disorder. It has a role as an antidepressant, a serotonin uptake inhibitor and an anxiolytic drug. It is a 5-methoxyvalerophenone O-(2-aminoethyl)oxime and a member of (trifluoromethyl)benzenes. It is functionally related to a (trifluoromethyl)benzene. |
| Classification | Small molecule |
| Drug class | Selective serotonin reuptake inhibitor (SSRI) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COCCCC/C(=N\OCCN)c1ccc(C(F)(F)F)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 54739-18-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL814 |
| ChEBI ID | 5138 |
| PubChem CID | 5324346 |
| DrugBank | DB00176 |
| UNII ID | O4L1XPO44W (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
SIGMAR1
SIGMAR1
Organism
Homo sapiens
Gene name
SIGMAR1
Gene synonyms
OPRS1, SRBP
NCBI Gene ID
Protein name
sigma non-opioid intracellular receptor 1
Protein synonyms
Aging-associated gene 8 protein, hSigmaR1, SIG-1R, Sigma 1-type opioid receptor, Sigma1-receptor, Sigma1R, SR-BP, SR31747 binding protein 1, SR31747-binding protein
Uniprot ID
Mouse ortholog
Sigmar1 (18391)
sigma non-opioid intracellular receptor 1 (O55242)
Variants
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Financial
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Luvox – Jazz Pharmaceuticals
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Estimated US medical usage
Fluvoxamine
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
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Safety
Black-box Warning
Black-box warning for: Fluvoxamine maleate
Adverse Events
Top Adverse Reactions
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4,219 adverse events reported
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