Fluvoxamine
Fluvoxamine, Luvox (fluvoxamine) is a small molecule pharmaceutical. Fluvoxamine was first approved as Luvox on 1994-12-05. It is used to treat depressive disorder, obsessive-compulsive disorder, and panic disorder in the USA. The pharmaceutical is active against sodium-dependent serotonin transporter. In addition, it is known to target sigma non-opioid intracellular receptor 1.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| mental disorders | D001523 |
Trade Name
FDA
EMA
Fluvoxamine, Luvox (discontinued: Fluvoxamine, Luvox)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Fluvoxamine maleate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| LUVOX | ANI Pharmaceuticals | N-021519 RX | 2007-12-20 | 3 products, RLD |
Show 2 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| fluvoxamine maleate | ANDA | 2025-10-01 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
102 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Fluvoxamine |
| INN | fluvoxamine |
| Description | Fluvoxamine is an oxime O-ether that is benzene substituted by a (1E)-N-(2-aminoethoxy)-5-methoxypentanimidoyl group at position 1 and a trifluoromethyl group at position 4. It is a selective serotonin reuptake inhibitor that is used for the treatment of obsessive-compulsive disorder. It has a role as an antidepressant, a serotonin uptake inhibitor and an anxiolytic drug. It is a 5-methoxyvalerophenone O-(2-aminoethyl)oxime and a member of (trifluoromethyl)benzenes. It is functionally related to a (trifluoromethyl)benzene. |
| Classification | Small molecule |
| Drug class | Selective serotonin reuptake inhibitor (SSRI) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COCCCC/C(=N\OCCN)c1ccc(C(F)(F)F)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 54739-18-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL814 |
| ChEBI ID | 5138 |
| PubChem CID | 5324346 |
| DrugBank | DB00176 |
| UNII ID | O4L1XPO44W (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
SIGMAR1
SIGMAR1
Organism
Homo sapiens
Gene name
SIGMAR1
Gene synonyms
OPRS1, SRBP
NCBI Gene ID
Protein name
sigma non-opioid intracellular receptor 1
Protein synonyms
Aging-associated gene 8 protein, hSigmaR1, SIG-1R, Sigma 1-type opioid receptor, Sigma1-receptor, Sigma1R, SR-BP, SR31747 binding protein 1, SR31747-binding protein
Uniprot ID
Mouse ortholog
Sigmar1 (18391)
sigma non-opioid intracellular receptor 1 (O55242)
Variants
No data
Financial
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Luvox – Jazz Pharmaceuticals
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Estimated US medical usage
Fluvoxamine
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 10,846 documents
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Safety
Black-box Warning
Black-box warning for: Fluvoxamine maleate
Adverse Events
Top Adverse Reactions
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3,873 adverse events reported
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