Flurbiprofen
Flurbiprofen (flurbiprofen) is a small molecule pharmaceutical. Flurbiprofen was first approved as Ocufen on 1986-12-31. It is used to treat inflammation, macular edema, miosis, osteoarthritis, and rheumatoid arthritis in the USA. The pharmaceutical is active against prostaglandin G/H synthase 2 and prostaglandin G/H synthase 1. In addition, it is known to target acid-sensing ion channel 1.
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Commercial
Trade Name
FDA
EMA
Flurbiprofen (discontinued: Ansaid, Flurbiprofen, Ocufen)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Flurbiprofen sodium
Flurbiprofen
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ANSAID | Pharmacia & Upjohn | N-018766 DISCN | 1988-10-31 | 2 products, RLD |
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FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| antiphlamine pain relieving | unapproved drug other | 2015-10-13 |
| flurbiprofen | ANDA | 2025-10-17 |
| flurbiprofen sodium | ANDA | 2024-07-24 |
| lurbiro | ANDA | 2025-07-30 |
| rinol-stroche | unapproved drug other | 2024-10-31 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
M: Musculo-skeletal system drugs
— M01: Antiinflammatory and antirheumatic products
— M01A: Antiinflammatory and antirheumatic products, non-steroids
— M01AE: Propionic acid derivatives, antiinflammatory and antirheumatic products
— M01AE09: Flurbiprofen
— M02: Topical products for joint and muscular pain
— M02A: Topical products for joint and muscular pain
— M02AA: Antiinflammatory preparations, non-steroids for topical use
— M02AA19: Flurbiprofen
R: Respiratory system drugs
— R02: Throat preparations
— R02A: Throat preparations
— R02AX: Other throat preparations in atc
— R02AX01: Flurbiprofen
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01B: Antiinflammatory agents, ophthalmologic
— S01BC: Antiinflammatory agents, non-steroidal, ophthalmologic
— S01BC04: Flurbiprofen
HCPCS
No data
Clinical
Clinical Trials
115 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Postoperative pain | D010149 | — | G89.18 | 1 | — | — | 4 | 9 | 14 |
| Pain | D010146 | EFO_0003843 | R52 | — | 1 | — | 4 | 5 | 10 |
| Agnosia | D000377 | EFO_0007136 | F88 | — | 1 | 1 | 3 | 2 | 6 |
| Low back pain | D017116 | — | M54.5 | — | 1 | — | 1 | 1 | 3 |
| Back pain | D001416 | — | M54 | — | 1 | — | 1 | 1 | 3 |
| Patient-controlled analgesia | D016058 | — | — | — | 1 | 1 | 1 | 1 | 3 |
| Periodontitis | D010518 | EFO_0000649 | K05.3 | — | 2 | — | 1 | — | 3 |
| Depression | D003863 | — | F33.9 | — | — | — | 1 | 1 | 2 |
| Postoperative complications | D011183 | — | — | — | — | — | 1 | 1 | 2 |
| Non-small-cell lung carcinoma | D002289 | — | — | — | — | — | 2 | — | 2 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pharyngitis | D010612 | — | R07.0 | — | 1 | 3 | — | — | 4 |
| Deglutition disorders | D003680 | — | R13.1 | — | — | 1 | — | — | 1 |
| Esophageal neoplasms | D004938 | — | C15 | — | 1 | 1 | — | — | 1 |
| Anesthesia and analgesia | D000760 | — | — | — | 1 | 1 | — | — | 1 |
| Simian acquired immunodeficiency syndrome | D016097 | — | — | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 16 | 1 | — | — | 2 | 18 |
| Colorectal neoplasms | D015179 | — | — | 1 | 1 | — | — | 1 | 2 |
| Respiratory tract infections | D012141 | — | J06.9 | 1 | 1 | — | — | — | 2 |
| Neoplasms | D009369 | — | C80 | 1 | 1 | — | — | — | 1 |
| Melanoma | D008545 | — | — | 1 | 1 | — | — | — | 1 |
| Uveal neoplasms | D014604 | EFO_1001230 | — | 1 | 1 | — | — | — | 1 |
| Uveal melanoma | D000098943 | — | — | 1 | 1 | — | — | — | 1 |
| Prostatic neoplasms | D011471 | — | C61 | — | 1 | — | — | — | 1 |
| Recurrence | D012008 | — | — | — | 1 | — | — | — | 1 |
| Gynatresia | D006175 | EFO_1001335 | N85.6 | 1 | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Drug interactions | D004347 | — | — | 3 | — | — | — | 2 | 5 |
| Arthritis | D001168 | EFO_0005856 | M05-M14 | 3 | — | — | — | 1 | 4 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 3 | — | — | — | — | 3 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | 3 | — | — | — | — | 3 |
| Infections | D007239 | EFO_0000544 | — | 2 | — | — | — | — | 2 |
| Mitochondrial diseases | D028361 | EFO_0000591 | — | 1 | — | — | — | — | 1 |
| Leukemia | D007938 | — | C95 | 1 | — | — | — | — | 1 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 1 | — | — | — | — | 1 |
| Myeloid leukemia | D007951 | — | C92 | 1 | — | — | — | — | 1 |
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | 1 | — | — | — | — | 1 |
Show 13 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Anesthesia | D000758 | — | — | — | — | — | — | 4 | 4 |
| Chronic pancreatitis | D050500 | EFO_0000342 | K86.1 | — | — | — | — | 3 | 3 |
| Postoperative nausea and vomiting | D020250 | EFO_0004888 | — | — | — | — | — | 2 | 2 |
| Vomiting | D014839 | — | R11.1 | — | — | — | — | 2 | 2 |
| Hyperalgesia | D006930 | — | — | — | — | — | — | 2 | 2 |
| Pancreatitis | D010195 | EFO_0000278 | K85 | — | — | — | — | 2 | 2 |
| Analgesia | D000698 | — | — | — | — | — | — | 2 | 2 |
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | — | — | — | 1 | 1 |
| Migraine disorders | D008881 | EFO_0003821 | G43 | — | — | — | — | 1 | 1 |
| Headache | D006261 | — | R51 | — | — | — | — | 1 | 1 |
Show 34 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Flurbiprofen |
| INN | flurbiprofen |
| Description | Flurbiprofen is a monocarboxylic acid that is a 2-fluoro-[1,1'-biphenyl-4-yl] moiety linked to C-2 of propionic acid. A non-steroidal anti-inflammatory, analgesic and antipyretic, it is used as a pre-operative anti-miotic as well as orally for arthritis or dental pain. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antipyretic and an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor. It is a fluorobiphenyl and a monocarboxylic acid. It is functionally related to a propionic acid. It derives from a hydride of a biphenyl. |
| Classification | Small molecule |
| Drug class | anti-inflammatory/analgesic agents (ibuprofen type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(C(=O)O)c1ccc(-c2ccccc2)c(F)c1 |
Identifiers
| PDB | — |
| CAS-ID | 5104-49-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL563 |
| ChEBI ID | 5130 |
| PubChem CID | 3394 |
| DrugBank | DB00712 |
| UNII ID | 5GRO578KLP (ChemIDplus, GSRS) |
Target
Agency Approved
PTGS2
PTGS2
PTGS1
PTGS1
Organism
Homo sapiens
Gene name
PTGS2
Gene synonyms
COX2
NCBI Gene ID
Protein name
prostaglandin G/H synthase 2
Protein synonyms
COX-2, cyclooxygenase 2, cyclooxygenase 2b, Cyclooxygenase-2, PGH synthase 2, PGHS-2, PHS II, Prostaglandin H2 synthase 2, Prostaglandin-endoperoxide synthase 2, prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
Uniprot ID
Mouse ortholog
Ptgs2 (19225)
prostaglandin G/H synthase 2 (Q543K3)
Alternate
ASIC1
ASIC1
Organism
Homo sapiens
Gene name
ASIC1
Gene synonyms
ACCN2, BNAC2
NCBI Gene ID
Protein name
acid-sensing ion channel 1
Protein synonyms
acid sensing (proton gated) ion channel 1, acid-sensing ion channel 1a protein, Amiloride-sensitive cation channel 2, neuronal, BNaC2, Brain sodium channel 2, Cation channel, amiloride-sensitive, neuronal, 2
Uniprot ID
Mouse ortholog
Asic1 (11419)
acid-sensing ion channel 1 (Q6NXK8)
Variants
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Financial
Revenue by drug
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Estimated US medical usage
Flurbiprofen
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 11,362 documents
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Safety
Black-box Warning
Black-box warning for: Flurbiprofen, Lurbiro
Adverse Events
Top Adverse Reactions
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1,185 adverse events reported
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