Fezolinetant
Veozah (fezolinetant) is a small molecule pharmaceutical. Fezolinetant was first approved as Veozah on 2023-05-12. It is used to treat hot flashes in the USA. The pharmaceutical is active against neuromedin-K receptor.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
Veozah
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Fezolinetant
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| VEOZAH | Astellas Pharma | N-216578 RX | 2023-05-12 | 1 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| veozah | New Drug Application | 2024-12-27 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| hot flashes | — | D019584 | — |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
FEZOLINETANT, VEOZAH, ASTELLAS | |||
| 2028-05-12 | NCE | ||
HCPCS
No data
Clinical
Clinical Trials
26 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hot flashes | D019584 | — | — | — | 7 | 10 | — | 1 | 17 |
| Menopause | D008593 | EFO_0003922 | N95 | — | 2 | 1 | — | — | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Carcinoma | D002277 | — | C80.0 | — | 2 | — | — | — | 2 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 2 | — | — | — | 2 |
| Prostatic neoplasms | D011471 | — | C61 | — | 2 | — | — | — | 2 |
| Carcinoma in situ | D002278 | — | D09.9 | — | 1 | — | — | — | 1 |
| Ductal carcinoma breast | D018270 | — | — | — | 1 | — | — | — | 1 |
| Ductal carcinoma | D044584 | — | — | — | 1 | — | — | — | 1 |
| Intraductal carcinoma noninfiltrating | D002285 | — | D05.1 | — | 1 | — | — | — | 1 |
| Adenocarcinoma | D000230 | — | — | — | 1 | — | — | — | 1 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | — | 1 | — | — | — | 1 |
| Flushing | D005483 | — | R23.2 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 6 | — | — | — | — | 6 |
| Liver diseases | D008107 | EFO_0001421 | K70-K77 | 1 | — | — | — | — | 1 |
| Hepatic insufficiency | D048550 | — | — | 1 | — | — | — | — | 1 |
| Renal insufficiency | D051437 | — | N19 | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Fezolinetant |
| INN | fezolinetant |
| Description | Fezolinetant is a triazolopyrazine that is 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine substituted by 3-methyl-1,2,4-thiadiazol-5-yl, 4-fluorobenzoyl and methyl groups at positions 3, 7, and 8R, respectively. It is a prescription medicine used to reduce moderate to severe vasomotor symptoms due to menopause. It has a role as a neurokinin-3 receptor antagonist. It is a member of monofluorobenzenes, a triazolopyrazine, a member of thiadiazoles, a member of benzamides and a tertiary carboxamide. |
| Classification | Small molecule |
| Drug class | tachykinin (neurokinin) receptor antagonists: NK3 receptor antagonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)cc2)[C@@H]3C)n1 |
Identifiers
| PDB | — |
| CAS-ID | 1629229-37-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3608680 |
| ChEBI ID | — |
| PubChem CID | 117604931 |
| DrugBank | DB15669 |
| UNII ID | 83VNE45KXX (ChemIDplus, GSRS) |
Target
Agency Approved
TACR3
TACR3
Alternate
No data
Variants
No data
Financial
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Trends
PubMed Central
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Additional graphs summarizing 212 documents
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Safety
Black-box Warning
Black-box warning for: Veozah
Adverse Events
Top Adverse Reactions
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1,400 adverse events reported
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