Repatha(evolocumab)
Repatha (evolocumab) is an antibody pharmaceutical. Evolocumab was first approved as Repatha on 2015-07-17. It is used to treat atherosclerosis and hypercholesterolemia in the USA. It has been approved in Europe to treat dyslipidemias and hypercholesterolemia. The pharmaceutical is active against proprotein convertase subtilisin/kexin type 9.
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FDA approval date
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Patent expiration date
Study first post date
Last update post date
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| cardiovascular diseases | D002318 |
| nutritional and metabolic diseases | D009750 |
Trade Name
FDA
EMA
Repatha
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| repatha | Biologic Licensing Application | 2024-01-25 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| hypercholesterolemia | HP_0003124 | D006937 | — |
| atherosclerosis | EFO_0003914 | D050197 | I25.1 |
| dyslipidemias | HP_0003119 | D050171 | — |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
evolocumab, Repatha, Amgen Inc. | |||
| 2028-09-24 | Orphan excl. | ||
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
142 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypercholesterolemia | D006937 | HP_0003124 | — | — | 8 | 17 | 6 | 10 | 39 |
| Dyslipidemias | D050171 | HP_0003119 | — | 1 | 1 | 14 | 5 | 5 | 26 |
| Hyperlipidemias | D006949 | HP_0003077 | E78.5 | 2 | 3 | 12 | 5 | 2 | 24 |
| Atherosclerosis | D050197 | EFO_0003914 | I25.1 | — | 3 | — | 9 | 6 | 18 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | — | 3 | 3 | 5 | 3 | 14 |
| Hyperlipoproteinemia type ii | D006938 | EFO_0004911 | E78.00 | — | 4 | 6 | 3 | 3 | 14 |
| Coronary artery disease | D003324 | — | I25.1 | — | 2 | 2 | 4 | 5 | 13 |
| Hyperlipoproteinemias | D006951 | HP_0010980 | — | 1 | — | 6 | 4 | 2 | 13 |
| Coronary disease | D003327 | — | — | — | — | 2 | 4 | 5 | 11 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | 1 | 2 | 3 | 5 | 11 |
Show 41 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hiv infections | D015658 | EFO_0000764 | B20 | — | 1 | 1 | — | — | 2 |
| Covid-19 | D000086382 | — | — | — | — | 1 | — | — | 1 |
| Aortic valve stenosis | D001024 | HP_0001650 | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | 1 | — | — | — | 1 |
| Muscle spasticity | D009128 | HP_0001257 | — | 1 | 1 | — | — | — | 1 |
| Hereditary spastic paraplegia | D015419 | EFO_0000529 | G11.4 | 1 | 1 | — | — | — | 1 |
| Paraplegia | D010264 | HP_0001258 | G82.2 | 1 | 1 | — | — | — | 1 |
| Heart transplantation | D016027 | EFO_0010673 | — | — | 1 | — | — | — | 1 |
| Sepsis | D018805 | HP_0100806 | A41.9 | — | 1 | — | — | — | 1 |
| Toxemia | D014115 | — | — | — | 1 | — | — | — | 1 |
| Heart failure | D006333 | HP_0001635 | I50 | — | 1 | — | — | — | 1 |
| Hiv | D006678 | — | — | — | 1 | — | — | — | 1 |
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | — | 1 | — | — | — | 1 |
Show 3 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pharmacokinetics | D010599 | — | — | 1 | — | — | — | — | 1 |
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
| Pharmacological phenomena | D000069437 | — | — | 1 | — | — | — | — | 1 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.9 | 1 | — | — | — | — | 1 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | 1 | — | — | — | — | 1 |
| Pancreatic ductal carcinoma | D021441 | — | — | 1 | — | — | — | — | 1 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 1 | — | — | — | — | 1 |
| Adenocarcinoma | D000230 | — | — | 1 | — | — | — | — | 1 |
| Glioblastoma | D005909 | EFO_0000515 | — | 1 | — | — | — | — | 1 |
| Glioma | D005910 | EFO_0000520 | — | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Genetic testing | D005820 | — | — | — | — | — | — | 1 | 1 |
| Arthrogryposis | D001176 | EFO_0003857 | — | — | — | — | — | 1 | 1 |
| Medication adherence | D055118 | EFO_0006344 | — | — | — | — | — | 1 | 1 |
| Treatment adherence and compliance | D000074822 | — | — | — | — | — | — | 1 | 1 |
| Patient compliance | D010349 | — | — | — | — | — | — | 1 | 1 |
| Motivational interviewing | D062405 | — | — | — | — | — | — | 1 | 1 |
| Compliance | D003187 | — | — | — | — | — | — | 1 | 1 |
| Premature birth | D047928 | EFO_0003917 | O60 | — | — | — | — | 1 | 1 |
| Genetic polymorphism | D011110 | — | — | — | — | — | — | 1 | 1 |
| Cognition | D003071 | EFO_0003925 | — | — | — | — | — | 1 | 1 |
Show 4 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Evolocumab |
| INN | evolocumab |
| Description | Evolocumab (human mab) |
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL2364655 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | LKC0U3A8NJ (ChemIDplus, GSRS) |
Target
Agency Approved
PCSK9
PCSK9
Organism
Homo sapiens
Gene name
PCSK9
Gene synonyms
NARC1
NCBI Gene ID
Protein name
proprotein convertase subtilisin/kexin type 9
Protein synonyms
convertase subtilisin/kexin type 9 preproprotein, NARC-1, neural apoptosis regulated convertase 1, Neural apoptosis-regulated convertase 1, PC9, Proprotein convertase 9, Subtilisin/kexin-like protease PC9
Uniprot ID
Mouse ortholog
Pcsk9 (100102)
proprotein convertase subtilisin/kexin type 9 (Q8CFT6)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
€
£
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Repatha – Amgen
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Tabular view
Estimated US medical usage
Evolocumab
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 4,138 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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128,145 adverse events reported
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