Intelence(etravirine)
Etravirine, Intelence (etravirine) is a small molecule pharmaceutical. Etravirine was first approved as Intelence on 2008-01-18. It is used to treat HIV infections in the USA. It has been approved in Europe to treat HIV infections.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| infections | D007239 |
| urogenital diseases | D000091642 |
| immune system diseases | D007154 |
Trade Name
FDA
EMA
Etravirine, Intelence (discontinued: Etravirine)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Etravirine
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| INTELENCE | Johnson & Johnson | N-022187 RX | 2008-01-18 | 3 products, RLD |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| etravirine | ANDA | 2026-01-13 |
| intelence | New Drug Application | 2023-08-15 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| hiv infections | EFO_0000764 | D015658 | B20 |
Agency Specific
FDA
EMA
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Patent Expiration
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HCPCS
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Clinical
Clinical Trials
88 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hiv infections | D015658 | EFO_0000764 | B20 | 9 | 15 | 12 | 10 | 13 | 56 |
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | 5 | 7 | 3 | 4 | 8 | 26 |
| Hiv | D006678 | — | O98.7 | 5 | 1 | 7 | 4 | 6 | 23 |
| Infections | D007239 | EFO_0000544 | — | 4 | 3 | 1 | 1 | 2 | 11 |
| Hepatitis c | D006526 | — | B19.2 | 1 | — | 1 | 1 | 2 | 5 |
| Hepatitis | D006505 | — | K75.9 | 1 | — | 1 | 1 | 2 | 5 |
| Immunologic deficiency syndromes | D007153 | — | D84.9 | — | 2 | — | 1 | 2 | 5 |
| Hepatitis a | D006506 | EFO_0007305 | B15 | — | — | 1 | 1 | 2 | 4 |
| Chronic hepatitis c | D019698 | EFO_0004220 | B18.2 | — | — | 1 | 1 | 1 | 3 |
| Hepatitis b | D006509 | — | — | — | — | — | 1 | 1 | 2 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hiv-2 | D015498 | — | — | — | 1 | — | — | 1 | 2 |
| Sarcoma | D012509 | — | — | — | 1 | — | — | — | 1 |
| Kaposi sarcoma | D012514 | — | C46 | — | 1 | — | — | — | 1 |
| Ataxia | D001259 | — | R27.0 | — | 1 | — | — | — | 1 |
| Friedreich ataxia | D005621 | Orphanet_95 | G11.11 | — | 1 | — | — | — | 1 |
| Cerebellar ataxia | D002524 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 4 | — | — | — | — | 4 |
| Pharmacokinetics | D010599 | — | — | 1 | — | — | — | — | 1 |
| Neoplasms | D009369 | — | C80 | 1 | — | — | — | — | 1 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 1 | — | — | — | — | 1 |
| Mycoses | D009181 | — | B35-B49 | 1 | — | — | — | — | 1 |
| Insulin resistance | D007333 | EFO_0002614 | E88.819 | 1 | — | — | — | — | 1 |
| Inflammation | D007249 | MP_0001845 | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic hepatitis b | D019694 | EFO_0004239 | B18.1 | — | — | — | — | 1 | 1 |
| Sleep wake disorders | D012893 | — | G47 | — | — | — | — | 1 | 1 |
| Depression | D003863 | — | F33.9 | — | — | — | — | 1 | 1 |
| Hiv seropositivity | D006679 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Etravirine |
| INN | etravirine |
| Description | Etravirine is an aminopyrimidine that consists of 2,6-diaminopyrimidine bearing a bromo substituent at position 5, a 4-cyano-2,6-dimethylphenoxy substituent at position 4 and having a 4-cyanophenyl substituent attached to the 2-amino group. NNRTI of HIV-1, binds directly to RT and blocks RNA-dependent and DNA-dependent DNA polymerase activities It has a role as a HIV-1 reverse transcriptase inhibitor and an antiviral agent. It is a dinitrile, an organobromine compound, an aminopyrimidine and an aromatic ether. |
| Classification | Small molecule |
| Drug class | antivirals: non-nucleoside reverse transcriptase inhibitors, not benzoxazinone derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1cc(C#N)cc(C)c1Oc1nc(Nc2ccc(C#N)cc2)nc(N)c1Br |
Identifiers
| PDB | — |
| CAS-ID | 269055-15-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL308954 |
| ChEBI ID | 63589 |
| PubChem CID | 193962 |
| DrugBank | DB06414 |
| UNII ID | 0C50HW4FO1 (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Estimated US medical usage
Etravirine
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
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Additional graphs summarizing 3,787 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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3,949 adverse events reported
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