Epirubicin
Ellence, Epirubicin (epirubicin) is a small molecule pharmaceutical. Epirubicin was first approved as Ellence on 1999-09-15. It is used to treat breast neoplasms in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| neoplasms | D009369 |
| skin and connective tissue diseases | D017437 |
Trade Name
FDA
EMA
Ellence, Epirubicin (discontinued: Epirubicin)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| ellence | New Drug Application | 2025-07-30 |
| epirubicin hydrochloride | 2008-06-11 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| breast neoplasms | EFO_0003869 | D001943 | C50 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J9178 | Injection, epirubicin hcl, 2 mg |
Clinical
Clinical Trials
682 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 5 | 2 | 1 | 2 | 10 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Adenocarcinoma | D000230 | — | — | — | — | 1 | — | 1 | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Prostatic neoplasms | D011471 | — | C61 | — | 1 | — | — | — | 1 |
| Esophageal neoplasms | D004938 | — | C15 | — | 1 | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Epirubicin |
| INN | epirubicin |
| Description | 4'-epidoxorubicin is an anthracycline that is the 4'-epi-isomer of doxorubicin. It has a role as an EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor, an antineoplastic agent and an antimicrobial agent. It is an anthracycline, a deoxy hexoside, an anthracycline antibiotic, an aminoglycoside, a monosaccharide derivative, a member of p-quinones, a primary alpha-hydroxy ketone and a tertiary alpha-hydroxy ketone. It is functionally related to a doxorubicin. It is a conjugate acid of a 4'-epidoxorubicinium. |
| Classification | Small molecule |
| Drug class | antineoplastic antibiotics (daunorubicin type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 |
Identifiers
| PDB | — |
| CAS-ID | 56420-45-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL417 |
| ChEBI ID | 47898 |
| PubChem CID | 41867 |
| DrugBank | DB00445 |
| UNII ID | 3Z8479ZZ5X (ChemIDplus, GSRS) |
Target
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Variants
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Trends
PubMed Central
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Additional graphs summarizing 9,999 documents
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Safety
Black-box Warning
Black-box warning for: Ellence, Epirubicin hydrochloride
Adverse Events
Top Adverse Reactions
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23,117 adverse events reported
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