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Drug ReportsEpacadostat
Epacadostat
Epacadostat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against indoleamine 2,3-dioxygenase 1.
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Variants
Financial
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Events Timeline
5D
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3M
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YTD
1Y
2Y
5Y
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Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
L: Antineoplastic and immunomodulating agents
— L01: Antineoplastic agents
— L01X: Other antineoplastic agents in atc
— L01XX: Other antineoplastic agents in atc
— L01XX58: Epacadostat
HCPCS
No data
Clinical
Clinical Trials
60 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Head and neck neoplasmsD006258——352——7
Lung neoplasmsD008175HP_0100526C34.90351——6
MelanomaD008545——341——5
Renal cell carcinomaD002292EFO_0000376—111——2
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369—C80149———14
Ovarian neoplasmsD010051EFO_0003893C5655———7
Fallopian tube neoplasmsD005185——53———5
GlioblastomaD005909EFO_0000515—22———3
LymphomaD008223—C85.933———3
Squamous cell carcinoma of head and neckD000077195———3———3
Colorectal neoplasmsD015179——22———2
Endometrial neoplasmsD016889EFO_0004230—12———2
Pancreatic neoplasmsD010190EFO_0003860C25—2———2
Stomach neoplasmsD013274EFO_0003897C1612———2
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Non-small-cell lung carcinomaD002289——3————3
RecurrenceD012008——1————1
Hematologic neoplasmsD019337——1————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameEpacadostat
INNepacadostat
Description
Epacadostat (previously INCB24360) is an investigational drug for cancer. Epacadostat is an inhibitor of indoleamine 2,3-dioxygenase-1 (IDO1). Epacadostat inhibits IDO1 by competitively blocking it, without interfering with IDO2 or tryptophan 2,3-dioxygenase (TDO). It has antitumor activity in some models, though is most effective when combined with other immunotherapy agents.
Classification
Small molecule
Drug classenzyme inhibitors: indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitors
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Structure (InChI/SMILES or Protein Sequence)
NS(=O)(=O)NCCNc1nonc1/C(=N/O)Nc1ccc(F)c(Br)c1
Identifiers
PDB—
CAS-ID1204669-37-3
RxCUI—
ChEMBL IDCHEMBL3545369
ChEBI ID—
PubChem CID—
DrugBankDB11717
UNII ID71596A9R13 (ChemIDplus, GSRS)
Target
Agency Approved
IDO1
IDO1
Organism
Homo sapiens
Gene name
IDO1
Gene synonyms
IDO, INDO
NCBI Gene ID
Protein name
indoleamine 2,3-dioxygenase 1
Protein synonyms
indolamine 2,3 dioxygenase, indole 2,3-dioxygenase, Indoleamine-pyrrole 2,3-dioxygenase
Uniprot ID
Mouse ortholog
Ido1 (15930)
indoleamine 2,3-dioxygenase 1 (P28776)
Alternate
No data
Variants
No data
Financial
No data
Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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97 adverse events reported
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