Epacadostat
Epacadostat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against indoleamine 2,3-dioxygenase 1.
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Clinical
Clinical Trials
60 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Carcinoma | D002277 | — | C80.0 | 4 | 6 | 4 | — | — | 12 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 3 | 5 | 1 | — | — | 6 |
| Head and neck neoplasms | D006258 | — | — | 3 | 3 | 2 | — | — | 5 |
| Melanoma | D008545 | — | — | 3 | 4 | 1 | — | — | 5 |
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | 2 | 1 | — | — | 4 |
| Transitional cell carcinoma | D002295 | — | — | 1 | 1 | 2 | — | — | 4 |
| Squamous cell carcinoma of head and neck | D000077195 | — | — | — | 1 | 2 | — | — | 3 |
| Squamous cell carcinoma | D002294 | — | — | — | 1 | 2 | — | — | 3 |
| Renal cell carcinoma | D002292 | EFO_0000376 | — | 1 | 1 | 1 | — | — | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 10 | 6 | — | — | — | 10 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 6 | 6 | — | — | — | 7 |
| Recurrence | D012008 | — | — | 1 | 3 | — | — | — | 3 |
| Fallopian tube neoplasms | D005185 | — | — | 3 | 2 | — | — | — | 3 |
| Colorectal neoplasms | D015179 | — | — | 2 | 2 | — | — | — | 2 |
| Glioblastoma | D005909 | EFO_0000515 | — | 1 | 2 | — | — | — | 2 |
| Lymphoma | D008223 | — | C85.9 | 2 | 2 | — | — | — | 2 |
| Endometrial neoplasms | D016889 | EFO_0004230 | — | 1 | 2 | — | — | — | 2 |
| Peritoneal neoplasms | D010534 | — | — | 2 | 2 | — | — | — | 2 |
| Ovarian epithelial carcinoma | D000077216 | — | — | 1 | 2 | — | — | — | 2 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hematologic neoplasms | D019337 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Epacadostat |
| INN | epacadostat |
| Description | Epacadostat (previously INCB24360) is an investigational drug for cancer. Epacadostat is an inhibitor of indoleamine 2,3-dioxygenase-1 (IDO1). Epacadostat inhibits IDO1 by competitively blocking it, without interfering with IDO2 or tryptophan 2,3-dioxygenase (TDO). It has antitumor activity in some models, though is most effective when combined with other immunotherapy agents.
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| Classification | Small molecule |
| Drug class | enzyme inhibitors: indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | NS(=O)(=O)NCCNc1nonc1/C(=N/O)Nc1ccc(F)c(Br)c1 |
Identifiers
| PDB | — |
| CAS-ID | 1204669-37-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3545369 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB11717 |
| UNII ID | 71596A9R13 (ChemIDplus, GSRS) |
Target
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IDO1
IDO1
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Safety
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98 adverse events reported
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