Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Carcinoma | D002277 | — | C80.0 | 1 | 3 | 3 | — | — | 6 |
Head and neck neoplasms | D006258 | — | — | 1 | 1 | 1 | — | — | 2 |
Renal cell carcinoma | D002292 | EFO_0000376 | — | 1 | 1 | 1 | — | — | 2 |
Transitional cell carcinoma | D002295 | — | — | — | — | 2 | — | — | 2 |
Melanoma | D008545 | — | — | 1 | 1 | 1 | — | — | 2 |
Squamous cell carcinoma of head and neck | D000077195 | — | — | — | — | 1 | — | — | 1 |
Squamous cell carcinoma | D002294 | — | — | — | — | 1 | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Non-small-cell lung carcinoma | D002289 | — | — | 1 | 2 | — | — | — | 3 |
Lung neoplasms | D008175 | — | C34.90 | 1 | 3 | — | — | — | 3 |
Neoplasms | D009369 | — | C80 | 2 | 1 | — | — | — | 2 |
Stomach neoplasms | D013274 | EFO_0003897 | C16 | 1 | 2 | — | — | — | 2 |
Colorectal neoplasms | D015179 | — | — | 1 | 1 | — | — | — | 1 |
Sarcoma | D012509 | — | — | — | 1 | — | — | — | 1 |
Recurrence | D012008 | — | — | — | 1 | — | — | — | 1 |
Esophageal neoplasms | D004938 | — | C15 | — | 1 | — | — | — | 1 |
Adenocarcinoma | D000230 | — | — | — | 1 | — | — | — | 1 |
Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | — | 1 | — | — | — | 1 |
Drug common name | Epacadostat |
INN | epacadostat |
Description | Epacadostat (previously INCB24360) is an investigational drug for cancer. Epacadostat is an inhibitor of indoleamine 2,3-dioxygenase-1 (IDO1). Epacadostat inhibits IDO1 by competitively blocking it, without interfering with IDO2 or tryptophan 2,3-dioxygenase (TDO). It has antitumor activity in some models, though is most effective when combined with other immunotherapy agents.
|
Classification | Small molecule |
Drug class | enzyme inhibitors: indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitors |
Image (chem structure or protein) | ![]() |
Structure (InChI/SMILES or Protein Sequence) | NS(=O)(=O)NCCNc1nonc1/C(=N/O)Nc1ccc(F)c(Br)c1 |
PDB | — |
CAS-ID | 1204669-37-3 |
RxCUI | — |
ChEMBL ID | CHEMBL3545369 |
ChEBI ID | — |
PubChem CID | — |
DrugBank | DB11717 |
UNII ID | 71596A9R13 (ChemIDplus, GSRS) |