Epacadostat
Epacadostat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against indoleamine 2,3-dioxygenase 1.
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60 clinical trials
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Carcinoma | D002277 | — | C80.0 | 1 | — | — | — | — | 1 |
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | — | — | — | — | 1 |
| Transitional cell carcinoma | D002295 | — | — | 1 | — | — | — | — | 1 |
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Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Epacadostat |
| INN | epacadostat |
| Description | Epacadostat (previously INCB24360) is an investigational drug for cancer. Epacadostat is an inhibitor of indoleamine 2,3-dioxygenase-1 (IDO1). Epacadostat inhibits IDO1 by competitively blocking it, without interfering with IDO2 or tryptophan 2,3-dioxygenase (TDO). It has antitumor activity in some models, though is most effective when combined with other immunotherapy agents.
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| Classification | Small molecule |
| Drug class | enzyme inhibitors: indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | NS(=O)(=O)NCCNc1nonc1/C(=N/O)Nc1ccc(F)c(Br)c1 |
Identifiers
| PDB | — |
| CAS-ID | 1204669-37-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3545369 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB11717 |
| UNII ID | 71596A9R13 (ChemIDplus, GSRS) |
Target
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IDO1
IDO1
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98 adverse events reported
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