Raptiva(efalizumab)
Raptiva (efalizumab) is an antibody pharmaceutical. Efalizumab was first approved as Raptiva on 2003-10-27. It is used to treat psoriasis in the USA. It has been approved in Europe to treat psoriasis. The pharmaceutical is active against integrin alpha-L.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| skin and connective tissue diseases | D017437 |
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
Reference product - 351(a)
Reference product - 351(a)
Interchangeable product - 351(k)
Interchangeable product - 351(k)
Biosimilar product - 351(k)
Biosimilar product - 351(k)
Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| psoriasis | EFO_0000676 | D011565 | L40 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
52 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Psoriasis | D011565 | EFO_0000676 | L40 | 2 | 1 | 8 | 14 | 7 | 31 |
| Arthritis | D001168 | EFO_0005856 | M05-M14 | 1 | 1 | — | 1 | 1 | 4 |
| Arthralgia | D018771 | — | M25.5 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Kidney transplantation | D016030 | — | — | 1 | 2 | 1 | — | — | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | 2 | 4 | — | — | — | 4 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | 1 | 2 | — | — | — | 2 |
| Atopic dermatitis | D003876 | EFO_0000274 | L20 | 1 | 1 | — | — | — | 2 |
| Dermatitis | D003872 | — | L30.9 | 1 | 1 | — | — | — | 2 |
| Autoimmune diseases | D001327 | EFO_0000540 | M30-M36 | 1 | 1 | — | — | — | 1 |
| Psychology rejection | D012059 | — | — | 1 | 1 | — | — | — | 1 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | 1 | 1 | — | — | — | 1 |
| Renal insufficiency | D051437 | — | N19 | 1 | 1 | — | — | — | 1 |
| Asthma | D001249 | EFO_0000270 | J45 | — | 1 | — | — | — | 1 |
| Hypersensitivity | D006967 | EFO_0003785 | T78.40 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Psoriatic arthritis | D015535 | EFO_0003778 | L40.5 | 1 | — | — | — | 1 | 2 |
| Macular edema | D008269 | — | — | 2 | — | — | — | — | 2 |
| Edema | D004487 | — | R60.9 | 2 | — | — | — | — | 2 |
| Macular degeneration | D008268 | EFO_0001365 | H35.30 | 1 | — | — | — | — | 1 |
| Uveitis | D014605 | EFO_1001231 | H20.9 | 1 | — | — | — | — | 1 |
| Eczema | D004485 | — | L30.9 | 1 | — | — | — | — | 1 |
| Hidradenitis suppurativa | D017497 | — | L73.2 | 1 | — | — | — | — | 1 |
| Hidradenitis | D016575 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Graft vs host disease | D006086 | — | D89.81 | — | — | — | — | 1 | 1 |
| Oral lichen planus | D017676 | — | — | — | — | — | — | 1 | 1 |
| Lichen planus | D008010 | — | L43 | — | — | — | — | 1 | 1 |
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Efalizumab |
| INN | efalizumab |
| Description | Immunoglobulin G1, anti-(human antigen CD11a) (human-mouse monoclonal hu1124 gamma1-chain), disulfide with human-mouse monoclonal hu1124 light chain, dimer |
| Classification | Antibody |
| Drug class | Fc fusion protein; monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | >3EO9:H|Efalizumab Fab fragment, heavy chain
EVQLVESGGGLVQPGGSLRLSCAASGYSFTGHWMNWVRQAPGKGLEWVGMIHPSDSETRYNQKFKDRFTISVDKSKNTLY
LQMNSLRAEDTAVYYCARGIYFYGTTYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV
SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKV
>3EO9:L|Efalizumab Fab fragment, light chain
DIQMTQSPSSLSASVGDRVTITCRASKTISKYLAWYQQKPGKAPKLLIYSGSTLQSGVPSRFSGSGSGTDFTLTISSLQP
EDFATYYCQQHNEYPLTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ
ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Identifiers
| PDB | 3EO9, 3EOA, 3EOB |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201575 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB00095 |
| UNII ID | XX2MN88N5D (ChemIDplus, GSRS) |
Target
Agency Approved
ITGAL
ITGAL
Organism
Homo sapiens
Gene name
ITGAL
Gene synonyms
CD11A
NCBI Gene ID
Protein name
integrin alpha-L
Protein synonyms
antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide, CD11 antigen-like family member A, CD11a, integrin gene promoter, integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), Leukocyte adhesion glycoprotein LFA-1 alpha chain, Leukocyte function-associated molecule 1 alpha chain, LFA-1 alpha, LFA-1A, lymphocyte function-associated antigen 1, alpha polypeptide
Uniprot ID
Mouse ortholog
Itgal (16408)
integrin alpha-L (Q3U159)
Alternate
No data
Variants
No data
Financial
No data
Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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3,924 adverse events reported
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