Dostarlimab
Jemperli (dostarlimab) is an antibody pharmaceutical. Dostarlimab was first approved as Jemperli on 2021-04-21. It has been approved in Europe to treat endometrial neoplasms. It is known to target programmed cell death protein 1.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| neoplasms | D009369 |
| urogenital diseases | D000091642 |
Trade Name
FDA
EMA
Jemperli
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| jemperli | Biologic Licensing Application | 2023-07-31 |
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J9272 | Injection, dostarlimab-gxly, 10 mg |
Clinical
Clinical Trials
77 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 11 | 9 | 1 | — | — | 19 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 2 | 5 | 3 | — | — | 9 |
| Endometrial neoplasms | D016889 | EFO_0004230 | — | 2 | 4 | 1 | — | 1 | 7 |
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | 3 | 1 | — | — | 4 |
| Colonic neoplasms | D003110 | — | C18 | — | 1 | 1 | — | — | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | 3 | — | — | — | 4 |
| Triple negative breast neoplasms | D064726 | — | — | — | 3 | — | — | — | 3 |
| Uterine cervical neoplasms | D002583 | HP_0030159 | — | — | 3 | — | — | — | 3 |
| Head and neck neoplasms | D006258 | — | — | 1 | 3 | — | — | — | 3 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 1 | 3 | — | — | — | 3 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 1 | 2 | — | — | — | 3 |
| Fallopian tube neoplasms | D005185 | — | — | 1 | 2 | — | — | — | 3 |
| Renal cell carcinoma | D002292 | EFO_0000376 | — | — | 2 | — | — | — | 2 |
| Pancreatic ductal carcinoma | D021441 | — | — | — | 2 | — | — | — | 2 |
| Melanoma | D008545 | — | — | 1 | 2 | — | — | — | 2 |
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Indications Phases 1
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Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Dostarlimab |
| INN | dostarlimab |
| Description | Dostarlimab, sold under the brand name Jemperli, is a monoclonal antibody used as an anti-cancer medication for the treatment of endometrial cancer. Dostarlimab is a programmed death receptor-1 (PD-1)–blocking monoclonal antibody.
|
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | >7WSL:H|heavy chain
EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYDMSWVRQAPGKGLEWVSTISGGGSYTYYQDSVKGRFTISRDNSKNTLY
LQMNSLRAEDTAVYYCASPYYAMDYWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSG
ALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHHHHHH
>7WSL:L|light chain
DIQLTQSPSFLSAYVGDRVTITCKASQDVGTAVAWYQQKPGKAPKLLIYWASTLHTGVPSRFSGSGSGTEFTLTISSLQP
EDFATYYCQHYSSYPWTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ
ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Identifiers
| PDB | 7WSL |
| CAS-ID | 2022215-59-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4298124 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB15627 |
| UNII ID | P0GVQ9A4S5 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
PDCD1
PDCD1
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,228 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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212 adverse events reported
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