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Drug ReportsDoconexent
Doconexent
Doconexent is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target free fatty acid receptor 1, transient receptor potential cation channel subfamily A member 1, retinoic acid receptor RXR-alpha, and potassium channel subfamily K member 10.
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Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
Brand Name
Status
Last Update
animi-3unapproved drug other2013-02-06
animi-3 with vitamin dunapproved drug other2011-05-23
bal-care dhaunapproved drug other2012-05-01
bal-care dha essentialunapproved drug other2012-05-01
bp vit 3unapproved drug other2025-02-13
c-nate dhaunapproved drug other2024-01-22
citranatal 90 dhaunapproved drug other2024-01-08
citranatal assureunapproved drug other2024-01-08
citranatal bloom dhaunapproved drug other2020-04-06
citranatal dhaunapproved drug other2020-07-28
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
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HCPCS
No data
Clinical
Clinical Trials
2828 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Breast neoplasmsD001943EFO_0003869C501213
Heart transplantationD016027EFO_001067311
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Ovarian neoplasmsD010051EFO_0003893C56123
LeukemiaD007938C95123
Colorectal neoplasmsD0151791113
Fallopian tube neoplasmsD00518522
B-cell chronic lymphocytic leukemiaD015451C91.122
Lymphoid leukemiaD007945C9122
Non-small-cell lung carcinomaD002289111
Peritoneal neoplasmsD01053411
Mucinous adenocarcinomaD002288111
Ductal carcinoma breastD018270111
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Renal cell carcinomaD002292EFO_000037611
Rectal neoplasmsD01200411
Biliary tract neoplasmsD001661C24.911
Essential thrombocythemiaD013920D47.311
Polycythemia veraD011087D4511
Primary myelofibrosisD055728D47.411
ThrombocytosisD013922D75.8311
PolycythemiaD011086EFO_0005804D75.111
Non-hodgkin lymphomaD008228C85.911
LymphomaD008223C85.911
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Myeloid leukemia acuteD015470C92.011
Myeloid leukemiaD007951C9211
Myelodysplastic syndromesD009190D4611
PreleukemiaD01128911
SyndromeD01357711
Multiple myelomaD009101C90.011
Plasma cell neoplasmsD05421911
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Stomach neoplasmsD013274EFO_0003897C1611
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameDoconexent
INNdoconexent
Description
All-cis-docosa-4,7,10,13,16,19-hexaenoic acid is a docosahexaenoic acid having six cis-double bonds at positions 4, 7, 10, 13, 16 and 19. It has a role as a nutraceutical, an antineoplastic agent, a human metabolite, a Daphnia tenebrosa metabolite, a mouse metabolite and an algal metabolite. It is a docosahexaenoic acid and an omega-3 fatty acid. It is a conjugate acid of a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate.
Classification
Small molecule
Drug class
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O
Identifiers
PDB
CAS-ID6217-54-5
RxCUI
ChEMBL IDCHEMBL367149
ChEBI ID28125
PubChem CID445580
DrugBankDB03756
UNII IDZAD9OKH9JC (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
KCNK10
KCNK10
Organism
Homo sapiens
Gene name
KCNK10
Gene synonyms
TREK2
NCBI Gene ID
Protein name
potassium channel subfamily K member 10
Protein synonyms
2P domain potassium channel TREK2, Outward rectifying potassium channel protein TREK-2, potassium channel TREK-2, potassium channel, subfamily K, member 10, potassium channel, two pore domain subfamily K, member 10, protein phosphatase 1, regulatory subunit 97, TREK-2 K(+) channel subunit, TWIK-related K+ channel 2
Uniprot ID
Mouse ortholog
Kcnk10 (72258)
potassium channel subfamily K member 10 (F6YU65)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
Black-box warning for: Citranatal 90 dha, Citranatal assure, Citranatal dha, Citranatal essence, Citranatal harmony, Citranatal harmony 2.1, Citranatal harmony 3.0, Citranatal medley, Nestabs dha, Nestabs one, Pnv-dha, Pnv-omega, Pre-tabs dha, Prenate dha, Prenate enhance, Prenate essential, Prenate mini, Prenate pixie, Prenate restore, Reaphirm plant source dha, Select-ob plus dha, Tristart dha, Vitafol, Vitafol fe plus, Vitafol-ob plus dha
Adverse Events
Top Adverse Reactions
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3,870 adverse events reported
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