Doconexent
Doconexent is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target free fatty acid receptor 1, transient receptor potential cation channel subfamily A member 1, retinoic acid receptor RXR-alpha, and potassium channel subfamily K member 10.
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Events Timeline
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Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
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Primary completion date
Completion date
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| animi-3 | unapproved drug other | 2013-02-06 |
| animi-3 with vitamin d | unapproved drug other | 2011-05-23 |
| bal-care dha | unapproved drug other | 2012-05-01 |
| bal-care dha essential | unapproved drug other | 2012-05-01 |
| bp vit 3 | unapproved drug other | 2025-02-13 |
| c-nate dha | unapproved drug other | 2024-01-22 |
| citranatal assure | unapproved drug other | 2026-01-08 |
| citranatal bloom dha | unapproved drug other | 2020-04-06 |
| citranatal essence | unapproved drug other | 2020-07-07 |
| citranatal harmony | unapproved drug other | 2012-01-18 |
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
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HCPCS
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Clinical
Clinical Trials
2930 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Psoriasis | D011565 | EFO_0000676 | L40 | — | 1 | 2 | 1 | 1 | 5 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | — | — | 1 | — | 1 |
| Hyperlipidemias | D006949 | EFO_0003774 | E78.5 | — | — | — | 1 | — | 1 |
| Familial combined hyperlipidemia | D006950 | EFO_0000492 | E78.49 | — | — | — | 1 | — | 1 |
| Hyperlipoproteinemias | D006951 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-small-cell lung carcinoma | D002289 | — | — | 2 | 2 | 3 | — | — | 7 |
| Triple negative breast neoplasms | D064726 | — | — | 1 | — | 2 | — | — | 3 |
| Crohn disease | D003424 | EFO_0000384 | K50 | — | — | 1 | — | 1 | 2 |
| Urinary bladder neoplasms | D001749 | — | C67 | 1 | 1 | 1 | — | — | 2 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | — | — | 2 | — | — | 2 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 1 | 1 | — | — | 2 |
| Polymyalgia rheumatica | D011111 | EFO_0008518 | M35.3 | — | — | 1 | — | — | 1 |
| Ulcerative colitis | D003093 | EFO_0000729 | K51 | — | — | 1 | — | — | 1 |
| Colitis | D003092 | EFO_0003872 | K52.9 | — | — | 1 | — | — | 1 |
| Ulcer | D014456 | MPATH_579 | — | — | — | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 7 | 3 | — | — | — | 8 |
| Melanoma | D008545 | — | — | 3 | 2 | — | — | — | 3 |
| Multiple myeloma | D009101 | — | C90.0 | 1 | 2 | — | — | — | 2 |
| Plasma cell neoplasms | D054219 | — | — | 1 | 2 | — | — | — | 2 |
| Colorectal neoplasms | D015179 | — | — | 1 | 1 | — | — | — | 2 |
| Carcinoma | D002277 | — | C80.0 | 2 | 1 | — | — | — | 2 |
| Head and neck neoplasms | D006258 | — | — | 1 | 2 | — | — | — | 2 |
| Squamous cell carcinoma of head and neck | D000077195 | — | — | 1 | 2 | — | — | — | 2 |
| Squamous cell carcinoma | D002294 | — | — | 1 | 2 | — | — | — | 2 |
| Esophageal neoplasms | D004938 | — | C15 | 2 | 2 | — | — | — | 2 |
Show 9 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Glioblastoma | D005909 | EFO_0000515 | — | 2 | — | — | — | — | 2 |
| Pharmacokinetics | D010599 | — | — | 1 | — | — | — | — | 1 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 1 | — | — | — | — | 1 |
| Hepatocellular carcinoma | D006528 | — | C22.0 | 1 | — | — | — | — | 1 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 1 | — | — | — | — | 1 |
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Doconexent |
| INN | doconexent |
| Description | All-cis-docosa-4,7,10,13,16,19-hexaenoic acid is a docosahexaenoic acid having six cis-double bonds at positions 4, 7, 10, 13, 16 and 19. It has a role as a nutraceutical, an antineoplastic agent, a human metabolite, a Daphnia tenebrosa metabolite, a mouse metabolite and an algal metabolite. It is a docosahexaenoic acid and an omega-3 fatty acid. It is a conjugate acid of a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 6217-54-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL367149 |
| ChEBI ID | 28125 |
| PubChem CID | 445580 |
| DrugBank | DB03756 |
| UNII ID | ZAD9OKH9JC (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
KCNK10
KCNK10
Organism
Homo sapiens
Gene name
KCNK10
Gene synonyms
TREK2
NCBI Gene ID
Protein name
potassium channel subfamily K member 10
Protein synonyms
2P domain potassium channel TREK2, Outward rectifying potassium channel protein TREK-2, potassium channel TREK-2, potassium channel, subfamily K, member 10, potassium channel, two pore domain subfamily K, member 10, protein phosphatase 1, regulatory subunit 97, TREK-2 K(+) channel subunit, TWIK-related K+ channel 2
Uniprot ID
Mouse ortholog
Kcnk10 (72258)
potassium channel subfamily K member 10 (F6YU65)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 9,999 documents
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Safety
Black-box Warning
Black-box warning for: Citranatal assure, Citranatal essence, Citranatal harmony, Citranatal harmony 2.1, Nestabs dha, Pnv-dha, Pnv-omega, Pre-tabs dha, Prenatal plus multivitamin plus dha minicaps, Prenate dha, Prenate enhance, Prenate essential, Prenate mini, Prenate pixie, Prenate restore, Reaphirm plant source dha, Select-ob plus dha, Tristart dha, Vitafol, Vitafol fe plus, Vitafol-ob plus dha
Adverse Events
Top Adverse Reactions
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3,885 adverse events reported
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