Doconexent
Doconexent is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target free fatty acid receptor 1, transient receptor potential cation channel subfamily A member 1, retinoic acid receptor RXR-alpha, and potassium channel subfamily K member 10.
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Commercial
Therapeutic Areas
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Trade Name
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Drug Products
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EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| animi-3 | unapproved drug other | 2013-02-06 |
| animi-3 with vitamin d | unapproved drug other | 2011-05-23 |
| bal-care dha | unapproved drug other | 2012-05-01 |
| bal-care dha essential | unapproved drug other | 2012-05-01 |
| bp vit 3 | unapproved drug other | 2023-10-11 |
| c-nate dha | unapproved drug other | 2024-01-22 |
| citranatal 90 dha | unapproved drug other | 2024-01-08 |
| citranatal assure | unapproved drug other | 2024-01-08 |
| citranatal bloom dha | unapproved drug other | 2020-04-06 |
| citranatal dha | unapproved drug other | 2020-07-28 |
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Agency Specific
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Clinical
Clinical Trials
2565 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Multiple myeloma | D009101 | — | C90.0 | 47 | 99 | 29 | 2 | 6 | 155 |
| Lymphoma | D008223 | — | C85.9 | 52 | 107 | 17 | 1 | 3 | 151 |
| Plasma cell neoplasms | D054219 | — | — | 45 | 92 | 27 | 2 | 5 | 145 |
| Leukemia | D007938 | — | C95 | 42 | 72 | 16 | 2 | 6 | 117 |
| Lymphoid leukemia | D007945 | — | C91 | 27 | 57 | 14 | 2 | 5 | 90 |
| Inflammation | D007249 | MP_0001845 | — | 4 | 11 | 7 | 7 | 47 | 73 |
| Healthy volunteers/patients | — | — | — | 30 | 3 | 4 | 3 | 33 | 72 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 17 | 25 | 11 | 2 | 18 | 70 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | — | 19 | 39 | 10 | 2 | 6 | 66 |
| Obesity | D009765 | EFO_0001073 | E66.9 | 5 | 7 | 4 | 2 | 43 | 59 |
Show 211 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Carcinoma | D002277 | — | C80.0 | 30 | 59 | 20 | — | 6 | 98 |
| Neoplasms | D009369 | — | C80 | 59 | 38 | 6 | — | 8 | 95 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 28 | 40 | 5 | — | — | 58 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 13 | 30 | 14 | — | 6 | 56 |
| Non-small-cell lung carcinoma | D002289 | — | — | 21 | 29 | 14 | — | 2 | 55 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 22 | 36 | 7 | — | — | 53 |
| Squamous cell carcinoma | D002294 | — | — | 15 | 33 | 4 | — | 5 | 50 |
| B-cell lymphoma | D016393 | — | — | 25 | 29 | 2 | — | — | 41 |
| Melanoma | D008545 | — | — | 25 | 21 | 2 | — | — | 40 |
| Follicular lymphoma | D008224 | — | C82 | 13 | 30 | 4 | — | 1 | 39 |
Show 245 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Mantle-cell lymphoma | D020522 | — | — | 11 | 19 | — | — | — | 25 |
| Waldenstrom macroglobulinemia | D008258 | HP_0005508 | C88.0 | 9 | 16 | — | — | — | 19 |
| Myelodysplastic syndromes | D009190 | — | D46 | 4 | 12 | — | — | — | 16 |
| Endometrial neoplasms | D016889 | EFO_0004230 | — | 6 | 6 | — | — | 3 | 13 |
| Preleukemia | D011289 | — | — | 3 | 9 | — | — | — | 12 |
| Paraproteinemias | D010265 | — | D47.2 | 2 | 10 | — | — | 1 | 11 |
| Sezary syndrome | D012751 | — | C84.1 | 4 | 6 | — | — | — | 8 |
| Central nervous system neoplasms | D016543 | — | — | 3 | 6 | — | — | 1 | 8 |
| Nervous system neoplasms | D009423 | — | — | 3 | 6 | — | — | 1 | 8 |
| Small cell lung carcinoma | D055752 | — | — | 3 | 5 | — | — | — | 8 |
Show 255 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Phenylketonurias | D010661 | — | E70.0 | 1 | — | — | — | 9 | 10 |
| Exercise | D015444 | EFO_0000483 | — | 1 | — | — | — | 6 | 7 |
| Healthy diet | D000072001 | — | — | 1 | — | — | — | 6 | 7 |
| Hypersensitivity | D006967 | HP_0012393 | T78.40 | 1 | — | — | — | 4 | 5 |
| Gestational diabetes | D016640 | HP_0009800 | O24.4 | 1 | — | — | — | 4 | 5 |
| Cholangiocarcinoma | D018281 | — | C22.1 | 3 | — | — | — | — | 3 |
| Myositis | D009220 | EFO_0000783 | G72.49 | 1 | — | — | — | 2 | 3 |
| Dermatitis | D003872 | HP_0011123 | L30.9 | 1 | — | — | — | 2 | 3 |
| Eclampsia | D004461 | HP_0100601 | O15 | 1 | — | — | — | 2 | 3 |
| Pregnancy-induced hypertension | D046110 | — | O13 | 1 | — | — | — | 2 | 3 |
Show 59 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Muscular atrophy | D009133 | HP_0003202 | — | — | — | — | — | 7 | 7 |
| Vitamin d deficiency | D014808 | EFO_0003762 | E55 | — | — | — | — | 6 | 6 |
| Bone fractures | D050723 | EFO_0003931 | T14.8 | — | — | — | — | 6 | 6 |
| Calculi | D002137 | — | — | — | — | — | — | 5 | 5 |
| Body composition | D001823 | — | — | — | — | — | — | 4 | 4 |
| Affect | D000339 | — | — | — | — | — | — | 4 | 4 |
| Nephrolithiasis | D053040 | — | N20.0 | — | — | — | — | 4 | 4 |
| Kidney calculi | D007669 | EFO_0004253 | N20 | — | — | — | — | 4 | 4 |
| Sleep | D012890 | GO_0030431 | — | — | — | — | — | 3 | 3 |
| Bone density | D015519 | EFO_0003923 | M85 | — | — | — | — | 3 | 3 |
Show 300 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Doconexent |
| INN | doconexent |
| Description | All-cis-docosa-4,7,10,13,16,19-hexaenoic acid is a docosahexaenoic acid having six cis-double bonds at positions 4, 7, 10, 13, 16 and 19. It has a role as a nutraceutical, an antineoplastic agent, a human metabolite, a Daphnia tenebrosa metabolite, a mouse metabolite and an algal metabolite. It is a docosahexaenoic acid and an omega-3 fatty acid. It is a conjugate acid of a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 6217-54-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL367149 |
| ChEBI ID | 28125 |
| PubChem CID | 445580 |
| DrugBank | DB03756 |
| UNII ID | ZAD9OKH9JC (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
KCNK10
KCNK10
Organism
Homo sapiens
Gene name
KCNK10
Gene synonyms
TREK2
NCBI Gene ID
Protein name
potassium channel subfamily K member 10
Protein synonyms
2P domain potassium channel TREK2, Outward rectifying potassium channel protein TREK-2, potassium channel TREK-2, potassium channel, subfamily K, member 10, potassium channel, two pore domain subfamily K, member 10, protein phosphatase 1, regulatory subunit 97, TREK-2 K(+) channel subunit, TWIK-related K+ channel 2
Uniprot ID
Mouse ortholog
Kcnk10 (72258)
potassium channel subfamily K member 10 (F6YU65)
Variants
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Financial
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Trends
PubMed Central
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Safety
Black-box Warning
Black-box warning for: Citranatal 90 dha, Citranatal assure, Citranatal dha, Citranatal essence, Citranatal harmony, Citranatal harmony 2.1, Citranatal harmony 3.0, Citranatal medley, Nestabs dha, Nestabs one, Pnv-dha, Pnv-omega, Pre-tabs dha, Prenaissance, Prenaissance plus, Prenatal plus multivitamin plus dha minicaps, Prenate dha, Prenate enhance, Prenate essential, Prenate mini, Prenate restore, Primacare, Reaphirm plant source dha, Select-ob plus dha, Tristart dha, Vitafol, Vitafol fe plus, Vitafol-ob plus dha
Adverse Events
Top Adverse Reactions
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3,651 adverse events reported
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