Doconexent
Doconexent is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target free fatty acid receptor 1, transient receptor potential cation channel subfamily A member 1, retinoic acid receptor RXR-alpha, and potassium channel subfamily K member 10.
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Commercial
Therapeutic Areas
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Trade Name
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Drug Products
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EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| animi-3 | unapproved drug other | 2013-02-06 |
| animi-3 with vitamin d | unapproved drug other | 2011-05-23 |
| bal-care dha | unapproved drug other | 2012-05-01 |
| bal-care dha essential | unapproved drug other | 2012-05-01 |
| bp vit 3 | unapproved drug other | 2023-10-11 |
| c-nate dha | unapproved drug other | 2024-01-22 |
| citranatal 90 dha | unapproved drug other | 2024-01-08 |
| citranatal assure | unapproved drug other | 2024-01-08 |
| citranatal bloom dha | unapproved drug other | 2020-04-06 |
| citranatal dha | unapproved drug other | 2020-07-28 |
Show 28 more
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Agency Specific
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Clinical
Clinical Trials
594 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Inflammation | D007249 | MP_0001845 | — | — | 7 | 5 | 2 | 18 | 30 |
| Hypertriglyceridemia | D015228 | EFO_0004211 | — | 4 | 3 | 9 | 4 | 8 | 27 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | — | 3 | 6 | 3 | 11 | 22 |
| Obesity | D009765 | EFO_0001073 | E66.9 | 2 | 1 | 1 | 1 | 12 | 16 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 1 | 1 | 2 | 1 | 9 | 14 |
| Non-alcoholic fatty liver disease | D065626 | EFO_0003095 | K75.81 | 1 | 3 | 3 | 1 | 3 | 9 |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | — | 3 | — | 2 | 4 | 9 |
| Cystic fibrosis | D003550 | EFO_0000390 | E84 | — | 3 | — | 1 | 4 | 8 |
| Child development | D002657 | — | — | — | 2 | 1 | 1 | 5 | 8 |
| Coronary artery disease | D003324 | — | I25.1 | — | 1 | 1 | 5 | 1 | 8 |
Show 42 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 5 | 1 | 2 | — | 18 | 26 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 5 | 4 | 1 | — | 7 | 16 |
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | 1 | 1 | 6 | — | 6 | 14 |
| Depression | D003863 | — | F33.9 | — | 4 | 5 | — | 4 | 12 |
| Attention deficit disorder with hyperactivity | D001289 | EFO_0003888 | F90 | — | 1 | 3 | — | 6 | 10 |
| Metabolic syndrome | D024821 | EFO_0000195 | E88.810 | 1 | 2 | 2 | — | 6 | 9 |
| Sarcopenia | D055948 | EFO_1000653 | M62.84 | 1 | — | 1 | — | 6 | 8 |
| Hypertension | D006973 | EFO_0000537 | I10 | 1 | 1 | 1 | — | 4 | 6 |
| Dry eye syndromes | D015352 | — | H04.12 | — | — | 1 | — | 5 | 6 |
| Overweight | D050177 | — | E66.3 | 2 | 2 | 1 | — | 2 | 6 |
Show 45 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cognitive dysfunction | D060825 | HP_0001268 | G31.84 | 1 | 1 | — | — | 3 | 5 |
| Dyslipidemias | D050171 | HP_0003119 | — | 1 | 1 | — | — | 3 | 5 |
| Autism spectrum disorder | D000067877 | HP_0000729 | F84.0 | — | 3 | — | — | 2 | 5 |
| Periodontitis | D010518 | EFO_0000649 | K05.3 | — | 1 | — | — | 3 | 4 |
| Ulcerative colitis | D003093 | EFO_0000729 | K51 | — | 1 | — | — | 2 | 3 |
| Pregnancy rate | D018873 | — | — | — | 1 | — | — | 2 | 3 |
| Follicular lymphoma | D008224 | — | C82 | 1 | 1 | — | — | — | 2 |
| Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | 1 | — | — | 1 | 2 |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | 2 | 1 | — | — | — | 2 |
| Chronic fatigue syndrome | D015673 | EFO_0004540 | G93.31 | — | 1 | — | — | 1 | 2 |
Show 40 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Insulin resistance | D007333 | HP_0000855 | E88.819 | 1 | — | — | — | 4 | 5 |
| Hypercholesterolemia | D006937 | HP_0003124 | — | 1 | — | — | — | 3 | 4 |
| Hyperlipidemias | D006949 | HP_0003077 | E78.5 | 1 | — | — | — | 3 | 4 |
| Pregnancy-induced hypertension | D046110 | — | O13 | 1 | — | — | — | 2 | 3 |
| Gestational diabetes | D016640 | HP_0009800 | O24.4 | 1 | — | — | — | 2 | 3 |
| Brain concussion | D001924 | — | S06.0 | 1 | — | — | — | 1 | 2 |
| Healthy diet | D000072001 | — | — | 1 | — | — | — | 1 | 2 |
| Female infertility | D007247 | EFO_0008560 | N97 | 1 | — | — | — | — | 1 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 1 | — | — | — | — | 1 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | 1 | — | — | — | — | 1 |
Show 6 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Phenylketonurias | D010661 | — | E70.0 | — | — | — | — | 7 | 7 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | — | — | — | — | 5 | 5 |
| Affect | D000339 | — | — | — | — | — | — | 4 | 4 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | — | — | — | 3 | 3 |
| Breast feeding | D001942 | — | — | — | — | — | — | 3 | 3 |
| Muscular atrophy | D009133 | HP_0003202 | — | — | — | — | — | 3 | 3 |
| Crohn disease | D003424 | EFO_0000384 | K50 | — | — | — | — | 2 | 2 |
| Polycystic ovary syndrome | D011085 | EFO_0000660 | E28.2 | — | — | — | — | 2 | 2 |
| Bone density | D015519 | EFO_0003923 | M85 | — | — | — | — | 2 | 2 |
| Cerebrovascular circulation | D002560 | — | — | — | — | — | — | 2 | 2 |
Show 76 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Doconexent |
| INN | doconexent |
| Description | All-cis-docosa-4,7,10,13,16,19-hexaenoic acid is a docosahexaenoic acid having six cis-double bonds at positions 4, 7, 10, 13, 16 and 19. It has a role as a nutraceutical, an antineoplastic agent, a human metabolite, a Daphnia tenebrosa metabolite, a mouse metabolite and an algal metabolite. It is a docosahexaenoic acid and an omega-3 fatty acid. It is a conjugate acid of a (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 6217-54-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL367149 |
| ChEBI ID | 28125 |
| PubChem CID | 445580 |
| DrugBank | DB03756 |
| UNII ID | ZAD9OKH9JC (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
KCNK10
KCNK10
Organism
Homo sapiens
Gene name
KCNK10
Gene synonyms
TREK2
NCBI Gene ID
Protein name
potassium channel subfamily K member 10
Protein synonyms
2P domain potassium channel TREK2, Outward rectifying potassium channel protein TREK-2, potassium channel TREK-2, potassium channel, subfamily K, member 10, potassium channel, two pore domain subfamily K, member 10, protein phosphatase 1, regulatory subunit 97, TREK-2 K(+) channel subunit, TWIK-related K+ channel 2
Uniprot ID
Mouse ortholog
Kcnk10 (72258)
potassium channel subfamily K member 10 (F6YU65)
Variants
No data
Financial
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Trends
PubMed Central
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Safety
Black-box Warning
Black-box warning for: Citranatal 90 dha, Citranatal assure, Citranatal dha, Citranatal essence, Citranatal harmony, Citranatal harmony 2.1, Citranatal harmony 3.0, Citranatal medley, Neonatal dha, Nestabs dha, Nestabs one, Pnv-dha, Pnv-omega, Pre-tabs dha, Prenaissance, Prenaissance plus, Prenatal plus multivitamin plus dha minicaps, Prenate dha, Prenate enhance, Prenate essential, Prenate mini, Prenate restore, Primacare, Select-ob plus dha, Tristart dha, Vitafol, Vitafol fe plus, Vitafol-ob plus dha
Adverse Events
Top Adverse Reactions
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772 adverse events reported
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