PharmaKB logo
Company Reports
Company Reports
Drug Reports
Drug Reports
Disease Reports
Disease Reports
Sets
Sets
Favorites
Favorites
Log in
Log in
AboutPricing
Drug ReportsDifenoxin
Difenoxin
Motofen (difenoxin) is a small molecule pharmaceutical. Difenoxin was first approved as Motofen on 1982-01-01. It is used to treat diarrhea in the USA.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Plot placeholder
Mock data
Subscribe for the real data
Commercial
Therapeutic Areas
Therapeutic Area
MeSH
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Combinations
Motofen (discontinued: Motofen)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Atropine sulfate
+
Difenoxin hydrochloride
Tradename
Company
Number
Date
Products
MOTOFENSebela PharmaceuticalsN-017744 RX1982-01-01
1 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
motofenNew Drug Application2018-12-14
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
uveitisHP_0000554D014605H20.9
diarrheaHP_0002014D003967R19.7
stomach ulcer—D013276K25
bradycardiaHP_0001662D001919R00.1
heart arrestEFO_0009492D006323I46
poisoningEFO_0008546D011041T65.91
sinoatrial block—D012848I45.5
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
— A07: Antidiarrheals, intestinal antiinflammatory/antiinfective agents
— A07D: Antipropulsives
— A07DA: Antipropulsives
— A07DA04: Difenoxin
HCPCS
No data
Clinical
No data
Drug
General
Drug common nameDifenoxin
INNdifenoxin
Description
Difenoxin is a piperidinemonocarboxylic acid that is 4-phenylpiperidine-4-carboxylic acid in which the hydrogen attached to the nitrogen atom is substituted by a 3-cyano-3,3-diphenylpropyl group. It has a role as an antidiarrhoeal drug. It is a piperidinemonocarboxylic acid, a tertiary amine and a nitrile.
Classification
Small molecule
Drug classfluoroquinolone derivatives, nonantibacterial indication (e.g., antineoplastic antibiotics)
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
N#CC(CCN1CCC(C(=O)O)(c2ccccc2)CC1)(c1ccccc1)c1ccccc1
Identifiers
PDB—
CAS-ID28782-42-5
RxCUI—
ChEMBL IDCHEMBL1201321
ChEBI ID4534
PubChem CID34328
DrugBankDB01501
UNII ID3ZZ5BJ9F2Q (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
₣
No data
Estimated US medical usage
Difenoxin
+
Atropine
Total medical expenditures per year (USD, in millions)
Plot placeholder
Mock data
Subscribe for the real data
Number of persons purchased
Plot placeholder
Mock data
Subscribe for the real data
Number of purchases
Plot placeholder
Mock data
Subscribe for the real data
Refill frequency
Plot placeholder
Mock data
Subscribe for the real data
Price per prescription (USD)
Plot placeholder
Mock data
Subscribe for the real data
Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Plot placeholder
Mock data
Subscribe for the real data
Additional graphs summarizing 42 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Plot placeholder
Mock data
Subscribe for the real data
84 adverse events reported
View more details
© 2020-2024 Collaborative Drug Discovery Inc. (CDD) | Terms of Use