Desipramine
Desipramine, Norpramin (desipramine) is a small molecule pharmaceutical. Desipramine was first approved as Pertofrane on 1982-01-01. It is used to treat attention deficit disorder with hyperactivity, depressive disorder, pain, psychotic affective disorders, and substance-related disorders in the USA. The pharmaceutical is active against sodium-dependent serotonin transporter and sodium-dependent noradrenaline transporter. In addition, it is known to target equilibrative nucleoside transporter 4, G protein-activated inward rectifier potassium channel 2, and G protein-activated inward rectifier potassium channel 4.
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Commercial
Trade Name
FDA
EMA
Desipramine, Norpramin (discontinued: Desipramine, Pertofrane)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Desipramine hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| NORPRAMIN | Validus Pharmaceuticals | N-014399 RX | 1982-01-01 | 6 products, RLD |
Show 1 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| desipramine hcl | ANDA | 2025-01-22 |
| desipramine hydrochloride | ANDA | 2026-09-17 |
| norpramin | New Drug Application | 2025-07-03 |
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Clinical
Clinical Trials
41 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Depression | D003863 | — | F33.9 | 4 | 1 | 3 | 2 | 3 | 13 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | — | 1 | 1 | 3 | 2 | 7 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | — | 1 | 1 | 2 | — | 4 |
| Substance-related disorders | D019966 | EFO_0003890 | F13 | — | 2 | — | 1 | — | 3 |
| Treatment-resistant depressive disorder | D061218 | — | — | — | — | — | 1 | 1 | 2 |
| Atrophy | D001284 | — | — | — | — | — | 1 | — | 1 |
| Chronic pain | D059350 | — | — | — | — | — | 1 | — | 1 |
| Neuroaxonal dystrophies | D019150 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Alcoholism | D000437 | EFO_0003829 | F10.1 | — | 1 | 1 | — | — | 2 |
| Irritable bowel syndrome | D043183 | EFO_0000555 | K58 | — | — | 1 | — | 1 | 2 |
| Gastroesophageal reflux | D005764 | EFO_0003948 | K21 | — | — | 1 | — | — | 1 |
| Pain | D010146 | EFO_0003843 | R52 | — | — | 1 | — | — | 1 |
| Herpes zoster | D006562 | EFO_0006510 | B02 | — | — | 1 | — | — | 1 |
| Post-traumatic stress disorders | D013313 | EFO_0001358 | F43.1 | — | — | 1 | — | — | 1 |
| Gastrointestinal diseases | D005767 | — | — | — | — | 1 | — | — | 1 |
| Abdominal pain | D015746 | EFO_0003766 | R10.9 | — | — | 1 | — | — | 1 |
| Constipation | D003248 | — | K59.0 | — | — | 1 | — | — | 1 |
| Colonic diseases | D003108 | — | — | — | — | 1 | — | — | 1 |
Show 2 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cocaine-related disorders | D019970 | — | F14 | — | 3 | — | — | — | 3 |
| Back pain | D001416 | — | M54 | — | 2 | — | — | — | 2 |
| Obstructive sleep apnea | D020181 | EFO_0003918 | G47.33 | — | 2 | — | — | — | 2 |
| Dual (psychiatry) diagnosis | D017831 | — | — | — | 1 | — | — | — | 1 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | 1 | — | — | — | 1 |
| Sciatica | D012585 | — | M54.3 | — | 1 | — | — | — | 1 |
| Sleep apnea syndromes | D012891 | EFO_0003877 | G47.3 | — | 1 | — | — | — | 1 |
| Apnea | D001049 | — | R06.81 | — | 1 | — | — | — | 1 |
| Lung neoplasms | D008175 | — | C34.90 | — | 1 | — | — | — | 1 |
| Small cell lung carcinoma | D055752 | — | — | — | 1 | — | — | — | 1 |
Show 3 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 3 | — | — | — | — | 3 |
| Neoplasms | D009369 | — | C80 | 1 | — | — | — | — | 1 |
| Erectile dysfunction | D007172 | EFO_0004234 | F52.21 | 1 | — | — | — | — | 1 |
| Cystic fibrosis | D003550 | EFO_0000390 | E84 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | — | — | — | 1 | 1 |
| Drug interactions | D004347 | — | — | — | — | — | — | 1 | 1 |
| Multiple myeloma | D009101 | — | C90.0 | — | — | — | — | 1 | 1 |
| Dyspepsia | D004415 | EFO_0008533 | K30 | — | — | — | — | 1 | 1 |
| Vulvar diseases | D014845 | — | — | — | — | — | — | 1 | 1 |
| Vulvar vestibulitis | D054515 | — | N94.810 | — | — | — | — | 1 | 1 |
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | — | — | — | — | 1 | 1 |
| Personality disorders | D010554 | — | F60.6 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Desipramine |
| INN | desipramine |
| Description | Desipramine is a dibenzoazepine consisting of 10,11-dihydro-5H-dibenzo[b,f]azepine substituted on nitrogen with a 3-(methylamino)propyl group. It has a role as an adrenergic uptake inhibitor, a serotonin uptake inhibitor, a cholinergic antagonist, an alpha-adrenergic antagonist, a H1-receptor antagonist, an EC 3.1.4.12 (sphingomyelin phosphodiesterase) inhibitor, an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor, an antidepressant and a drug allergen. It is a dibenzoazepine and a secondary amino compound. |
| Classification | Small molecule |
| Drug class | antidepressants (imipramine type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CNCCCN1c2ccccc2CCc2ccccc21 |
Identifiers
| PDB | — |
| CAS-ID | 50-47-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL72 |
| ChEBI ID | 47781 |
| PubChem CID | 2995 |
| DrugBank | DB01151 |
| UNII ID | TG537D343B (ChemIDplus, GSRS) |
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Desipramine
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Safety
Black-box Warning
Black-box warning for: Desipramine hydrochloride, Norpramin
Adverse Events
Top Adverse Reactions
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679 adverse events reported
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