DEMCIZUMAB
Hemlibra (demcizumab) is an antibody pharmaceutical. Demcizumab was first approved as Hemlibra on 2018-02-23. It has been approved in Europe to treat hemophilia a. The pharmaceutical is active against delta-like protein 4.
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Therapeutic Areas
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Abbreviated New Drug Application (ANDA)
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FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| hemlibra | Biologic Licensing Application | 2024-10-28 |
Indications
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Clinical
Clinical Trials
8 clinical trials
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Indications Phases 4
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-small-cell lung carcinoma | D002289 | — | — | 1 | 1 | — | — | — | 2 |
| Lung neoplasms | D008175 | — | C34.90 | 1 | 1 | — | — | — | 2 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 1 | 1 | — | — | — | 2 |
| Adenocarcinoma | D000230 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 2 | — | — | — | — | 2 |
| Colorectal neoplasms | D015179 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | DEMCIZUMAB |
| INN | demcizumab |
| Description | Demcizumab (humanized mab) |
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL2109384 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB12734 |
| UNII ID | SF168W7FW0 (ChemIDplus, GSRS) |
Target
Agency Approved
DLL4
DLL4
Organism
Homo sapiens
Gene name
DLL4
Gene synonyms
NCBI Gene ID
Protein name
delta-like protein 4
Protein synonyms
delta 4, delta ligand 4, delta-like 4 homolog, delta-like 4 protein, Delta4, Drosophila Delta homolog 4, notch ligand delta-2, notch ligand DLL4
Uniprot ID
Mouse ortholog
Dll4 (54485)
delta-like protein 4 (Q9JI71)
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Hemlibra – Roche
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Additional graphs summarizing 228 documents
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Safety
Black-box Warning
Black-box warning for: Hemlibra
Adverse Events
Top Adverse Reactions
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6,008 adverse events reported
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