Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 4 | 4 | — | — | — | 6 |
Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 2 | 3 | — | — | — | 4 |
Malignant mesothelioma | D000086002 | — | — | 2 | 2 | — | — | — | 4 |
Non-small-cell lung carcinoma | D002289 | — | — | 2 | 3 | — | — | — | 4 |
Neoplasms | D009369 | — | C80 | 3 | 1 | — | — | — | 3 |
Lung neoplasms | D008175 | HP_0100526 | C34.90 | — | 2 | — | — | — | 2 |
Multiple myeloma | D009101 | — | C90.0 | — | 2 | — | — | — | 2 |
Lymphoma | D008223 | — | C85.9 | — | 2 | — | — | — | 2 |
Uterine cervical neoplasms | D002583 | HP_0030159 | — | — | 2 | — | — | — | 2 |
Endometrioid carcinoma | D018269 | — | — | 1 | 1 | — | — | — | 2 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Ovarian epithelial carcinoma | D000077216 | — | — | 1 | — | — | — | — | 1 |
Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
Myelodysplastic syndromes | D009190 | — | D46 | 1 | — | — | — | — | 1 |
Myeloid leukemia acute | D015470 | — | C92.0 | 1 | — | — | — | — | 1 |
Myelomonocytic leukemia chronic | D015477 | — | C93.1 | 1 | — | — | — | — | 1 |
Glioblastoma | D005909 | EFO_0000515 | — | 1 | — | — | — | — | 1 |
Drug common name | DEFACTINIB |
INN | defactinib |
Description | Defactinib (INN, codenamed VS-6063) is an inhibitor of PTK2, also known as focal adhesion kinase (FAK), Pyk2, and MELK which was developed by Pfizer and licensed to Verastem Oncology as a potential treatment for solid tumors.
|
Classification | Small molecule |
Drug class | tyrosine kinase inhibitors |
Image (chem structure or protein) | |
Structure (InChI/SMILES or Protein Sequence) | CNC(=O)c1ccc(Nc2ncc(C(F)(F)F)c(NCc3nccnc3N(C)S(C)(=O)=O)n2)cc1 |
PDB | — |
CAS-ID | — |
RxCUI | — |
ChEMBL ID | CHEMBL3137331 |
ChEBI ID | — |
PubChem CID | 25117126 |
DrugBank | DB12282 |
UNII ID | 53O87HA2QU (ChemIDplus, GSRS) |