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Drug ReportsCytarabine
Cytarabine, Depocyte(cytarabine)
Cytarabine, DepoCyte, Vyxeos (cytarabine) is a small molecule pharmaceutical. Cytarabine was first approved as Cytarabine on 1982-01-01. It is used to treat leukemia, lymphoma, and meningeal neoplasms in the USA. It has been approved in Europe to treat meningeal neoplasms and myeloid leukemia acute.
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Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
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Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
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Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
neoplasmsD009369
nervous system diseasesD009422
hemic and lymphatic diseasesD006425
immune system diseasesD007154
Trade Name
FDA
EMA
Cytarabine (discontinued: Cytarabine, Cytosar-u, Depocyt)
Combinations
Vyxeos
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Cytarabine
Tradename
Company
Number
Date
Products
DEPOCYTPacira BioSciencesN-021041 DISCN1999-04-01
1 products, RLD
CYTARABINETevaN-016793 DISCN1982-01-01
4 products, RLD
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Cytarabine
+
Daunorubicin
Tradename
Company
Number
Date
Products
VYXEOSCelator PharmaceuticalsN-209401 RX2017-08-03
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
byun rakunapproved drug other2019-03-21
cytarabineANDA2025-04-07
vyxeosNew Drug Application2025-07-01
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
leukemia—D007938C95
lymphoma—D008223C85.9
meningeal neoplasmsEFO_0003851D008577C70
myeloid leukemia acute—D015470C92.0
precursor cell lymphoblastic leukemia-lymphoma—D054198C91.0
Agency Specific
FDA
EMA
Expiration
Code
CYTARABINE / DAUNORUBICIN, VYXEOS, CELATOR PHARMS
2028-03-30ODE-350
2024-08-03ODE-287
2024-03-30NPP
Patent Expiration
Patent
Expires
Flag
FDA Information
Cytarabine / Daunorubicin, Vyxeos, Celator Pharms
100289122032-10-15DPU-3149, U-3150
101661842032-10-15DPU-3149
108354922032-10-15U-3150
80928282029-04-01U-3147
80222792027-09-14DPU-3147
78509902027-01-23DPU-3147
92719312027-01-23DP
85184372026-06-07DP
84318062025-04-22DPU-3147
ATC Codes
L: Antineoplastic and immunomodulating agents
— L01: Antineoplastic agents
— L01B: Antimetabolites
— L01BC: Pyrimidine analogues, antineoplastic antimetabolites
— L01BC01: Cytarabine
— L01X: Other antineoplastic agents in atc
— L01XY: Combinations of antineoplastic agents
— L01XY01: Cytarabine and daunorubicin
HCPCS
Code
Description
J9098
Injection, cytarabine liposome, 10 mg
J9100
Injection, cytarabine, 100 mg
J9153
Injection, liposomal, 1 mg daunorubicin and 2.27 mg cytarabine
Clinical
Clinical Trials
1699 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
LeukemiaD007938—C95—1———1
Myeloid leukemia acuteD015470—C92.0—1———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCytarabine
INNcytarabine
Description
Cytarabine is a pyrimidine nucleoside in which cytosine is attached to D-arabinofuranose via a beta-N(1)-glycosidic bond. Used mainly in the treatment of leukaemia, especially acute non-lymphoblastic leukaemia, cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. It also has antiviral and immunosuppressant properties. It has a role as an antineoplastic agent, an antimetabolite, an antiviral agent and an immunosuppressive agent. It is a beta-D-arabinoside, a pyrimidine nucleoside and a monosaccharide derivative. It is functionally related to a cytosine.
Classification
Small molecule
Drug classantineoplastics (arabinofuranosyl derivatives)
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2O)c(=O)n1
Identifiers
PDB—
CAS-ID147-94-4
RxCUI—
ChEMBL IDCHEMBL803
ChEBI ID28680
PubChem CID6253
DrugBankDB00987
UNII ID04079A1RDZ (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
₣
Depocyte – Pacira BioSciences
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Vyxeos – Jazz Pharmaceuticals
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Tabular view
Estimated US medical usage
Cytarabine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 45,338 documents
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Safety
Black-box Warning
Black-box warning for: Cytarabine, Vyxeos
Adverse Events
Top Adverse Reactions
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58,572 adverse events reported
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