Corticotropin
Acthar, Cortrophin (corticotropin) is a protein pharmaceutical. Corticotropin was first approved as Purified cortrophin gel on 1982-01-01. It is used to treat collagen diseases, erythema multiforme, infantile spasms, multiple sclerosis, and nephrotic syndrome amongst others in the USA. The pharmaceutical is active against adrenocorticotropic hormone receptor. In addition, it is known to target CRHR1-IT1-CRHR1 protein, melanocortin receptor 5, melanocortin receptor 4, melanocyte-stimulating hormone receptor, melanocortin receptor 3, and corticotropin-releasing factor receptor 2.
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Acthar, Cortrophin (discontinued: Acth, Acthar, Corticotropin, Cortrophin)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Corticotropin
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| PURIFIED CORTROPHIN GEL | ANI Pharmaceuticals | N-008975 RX | 1982-01-01 | 1 products, RLD, RS |
| ACTHAR GEL (AUTOINJECTOR) | Mallinckrodt | N-008372 RX | 2024-02-29 | 2 products, RLD, RS |
| ACTHAR GEL | Mallinckrodt | N-008372 RX | 1982-01-01 | 1 products, RLD, RS |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| acthar | New Drug Application | 2024-06-28 |
| acthrel | Biologic Licensing Application | 2021-11-12 |
| h.p. acthar | New Drug Application | 2018-05-09 |
| purified cortrophin gel | New Drug Application | 2023-10-25 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Corticotropin, Acthar Gel, Mallinckrodt Ard | |||
| 11752199 | 2041-02-25 | U-3686, U-3687, U-3688 | |
HCPCS
Code | Description |
|---|---|
| J0800 | Injection, corticotropin, up to 40 units |
Clinical
Clinical Trials
324 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Syndrome | D013577 | — | — | 3 | 15 | 9 | 4 | 17 | 44 |
| Pituitary acth hypersecretion | D047748 | EFO_1001110 | E24.0 | 1 | 14 | 7 | 1 | 14 | 36 |
| Adrenal insufficiency | D000309 | — | — | 2 | — | — | 2 | 21 | 25 |
| Acth-secreting pituitary adenoma | D049913 | — | — | 1 | 9 | 4 | 1 | 4 | 18 |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | 1 | 3 | 3 | 7 | 4 | 17 |
| Sclerosis | D012598 | — | — | 1 | 5 | 4 | 4 | 4 | 16 |
| Pituitary diseases | D010900 | — | E23.7 | 1 | 5 | — | 2 | 7 | 15 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 1 | 2 | 2 | 6 | 1 | 12 |
| Arthritis | D001168 | HP_0001369 | M05-M14 | — | 1 | 1 | 7 | 2 | 11 |
| Healthy volunteers/patients | — | — | — | 4 | — | — | 2 | 5 | 11 |
Show 75 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cushing syndrome | D003480 | EFO_0003099 | E24 | 1 | 11 | 6 | — | 13 | 30 |
| Adrenocortical hyperfunction | D000308 | EFO_1000797 | — | 1 | 4 | 1 | — | 5 | 11 |
| Adenoma | D000236 | — | — | — | 2 | 1 | — | 5 | 8 |
| Brain edema | D001929 | EFO_1000845 | G93.6 | 1 | 2 | 3 | — | — | 5 |
| Hyperaldosteronism | D006929 | HP_0011736 | E26 | — | — | 1 | — | 4 | 5 |
| Edema | D004487 | HP_0000969 | R60.9 | 1 | 1 | 2 | — | — | 4 |
| Adrenocortical adenoma | D018246 | — | — | — | 1 | 1 | — | 2 | 4 |
| Fatigue | D005221 | HP_0012378 | R53.83 | 1 | 1 | 1 | — | 2 | 4 |
| Inflammation | D007249 | MP_0001845 | — | 1 | — | 1 | — | 1 | 3 |
| Recurrence | D012008 | — | — | — | 1 | 1 | — | 2 | 3 |
Show 8 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Obesity | D009765 | EFO_0001073 | E66.9 | 2 | 1 | — | — | 3 | 6 |
| Ectopic acth syndrome | D000182 | EFO_1001256 | E24.3 | 1 | 5 | — | — | — | 5 |
| Adrenal gland neoplasms | D000310 | EFO_0003850 | C74 | — | 2 | — | — | 3 | 5 |
| Neoplasms | D009369 | — | C80 | 1 | 2 | — | — | 1 | 4 |
| Central nervous system neoplasms | D016543 | — | — | 1 | 2 | — | — | 1 | 4 |
| Nervous system neoplasms | D009423 | — | — | 1 | 2 | — | — | 1 | 4 |
| Premature birth | D047928 | EFO_0003917 | O60 | — | 2 | — | — | 2 | 4 |
| Alcoholism | D000437 | EFO_0003829 | F10.1 | — | 2 | — | — | 2 | 4 |
| Premature cardiac complexes | D005117 | — | I49.40 | 1 | 4 | — | — | — | 4 |
| Hyperplasia | D006965 | EFO_0000536 | — | 1 | 2 | — | — | 1 | 4 |
Show 23 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Polycystic ovary syndrome | D011085 | EFO_0000660 | E28.2 | 3 | — | — | — | 4 | 7 |
| Hyperandrogenism | D017588 | — | — | 3 | — | — | — | 2 | 5 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | — | — | — | 3 | 4 |
| Overweight | D050177 | — | E66.3 | 1 | — | — | — | 1 | 2 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | 1 | — | — | — | 1 | 2 |
| Lymphoma | D008223 | — | C85.9 | 1 | — | — | — | 1 | 2 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | 1 | — | — | — | 1 | 2 |
| Substance-related disorders | D019966 | EFO_0003890 | F13 | 1 | — | — | — | 1 | 2 |
| Cocaine-related disorders | D019970 | — | F14 | 1 | — | — | — | 1 | 2 |
| Ketosis | D007662 | HP_0002919 | R82.4 | 1 | — | — | — | — | 1 |
Show 18 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hemorrhage | D006470 | MP_0001914 | R58 | — | — | — | — | 6 | 6 |
| Covid-19 | D000086382 | — | — | — | — | — | — | 4 | 4 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | — | — | — | — | 3 | 3 |
| Lung diseases | D008171 | HP_0002088 | J98.4 | — | — | — | — | 3 | 3 |
| Obstructive lung diseases | D008173 | HP_0006536 | — | — | — | — | — | 3 | 3 |
| Brain injuries | D001930 | — | S06.9 | — | — | — | — | 3 | 3 |
| Laron syndrome | D046150 | Orphanet_633 | E34.321 | — | — | — | — | 3 | 3 |
| Depression | D003863 | — | F33.9 | — | — | — | — | 3 | 3 |
| Gout | D006073 | EFO_0004274 | M10 | — | — | — | — | 2 | 2 |
| Hematologic neoplasms | D019337 | — | — | — | — | — | — | 2 | 2 |
Show 111 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Corticotropin |
| INN | corticotropin |
| Description | Corticotropin is a polypeptide hormone produced and secreted by the pituitary gland comprising 39 amino acid residues coupled in a linear sequence. The N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Corticotropin stimulates the cortex of the adrenal gland and boosts the synthesis of corticosteroids, mainly glucocorticoids but also sex steroids (androgens). It is used in the treatment of certain neurological disorders such as infantile spasms and multiple sclerosis, and diagnostically to investigate adrenocortical insufficiency. It has a role as a diagnostic agent. It is a polypeptide, a peptide hormone and a biomacromolecule. |
| Classification | Protein |
| Drug class | atropine derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | 9002-60-2 |
| RxCUI | 376 |
| ChEMBL ID | CHEMBL1201610 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB01285 |
| UNII ID | K0U68Q2TXA (ChemIDplus, GSRS) |
Target
Agency Approved
MC2R
MC2R
Organism
Homo sapiens
Gene name
MC2R
Gene synonyms
ACTHR
NCBI Gene ID
Protein name
adrenocorticotropic hormone receptor
Protein synonyms
ACTH receptor, Adrenocorticotropin receptor, corticotropin receptor, MC2 receptor, MC2-R, melanocortin 2 receptor (adrenocorticotropic hormone), Melanocortin receptor 2
Uniprot ID
Mouse ortholog
Mc2r (17200)
adrenocorticotropic hormone receptor (Q64326)
Alternate
LINC02210-CRHR1
LINC02210-CRHR1
MC5R
MC5R
MC4R
MC4R
MC1R
MC1R
MC3R
MC3R
CRHR2
CRHR2
Variants
No data
Financial
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Estimated US medical usage
Corticotropin
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 88,592 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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7,764 adverse events reported
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