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AboutPricing
Drug ReportsCorticotropin
Corticotropin
Acthar, Cortrophin (corticotropin) is a protein pharmaceutical. Corticotropin was first approved as Purified cortrophin gel on 1982-01-01. It is used to treat collagen diseases, erythema multiforme, infantile spasms, multiple sclerosis, and nephrotic syndrome amongst others in the USA. The pharmaceutical is active against adrenocorticotropic hormone receptor. In addition, it is known to target CRHR1-IT1-CRHR1 protein, melanocortin receptor 5, melanocortin receptor 4, melanocyte-stimulating hormone receptor, melanocortin receptor 3, and corticotropin-releasing factor receptor 2.
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Study first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
musculoskeletal diseasesD009140
nervous system diseasesD009422
eye diseasesD005128
urogenital diseasesD000091642
hemic and lymphatic diseasesD006425
skin and connective tissue diseasesD017437
immune system diseasesD007154
chemically-induced disordersD064419
Trade Name
FDA
EMA
Acthar, Cortrophin (discontinued: Acth, Acthar, Corticotropin, Cortrophin)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Corticotropin
Tradename
Company
Number
Date
Products
PURIFIED CORTROPHIN GELANI PharmaceuticalsN-008975 RX1982-01-01
1 products, RLD, RS
ACTHAR GEL (AUTOINJECTOR)MallinckrodtN-008372 RX2024-02-29
2 products, RLD, RS
ACTHAR GELMallinckrodtN-008372 RX1982-01-01
1 products, RLD, RS
Show 5 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
actharNew Drug Application2024-12-16
acthrelBiologic Licensing Application2021-11-12
h.p. actharNew Drug Application2018-05-09
purified cortrophin gelNew Drug Application2024-12-20
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
nephrotic syndromeEFO_0004255D009404N04
multiple sclerosisEFO_0003885D009103G35
uveitisHP_0000554D014605H20.9
sarcoidosisEFO_0000690D012507D80-D89
rheumatic diseases—D012216M79.0
infantile spasmsHP_0011097D013036G40.82
optic neuritisEFO_0007405D009902H46
collagen diseases—D003095—
erythema multiforme—D004892L51
serum sickness—D012713T80.6
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Corticotropin, Acthar Gel, Mallinckrodt Ard
117521992041-02-25U-3686, U-3687, U-3688
ATC Codes
H: Systemic hormonal preparations, excl. sex hormones and insulins
— H01: Pituitary and hypothalamic hormones and analogues
— H01A: Anterior pituitary lobe hormones and analogues
— H01AA: Acth and synthetic analog preparations
— H01AA01: Corticotropin
HCPCS
Code
Description
J0800
Injection, corticotropin, up to 40 units
Clinical
No data
Drug
General
Drug common nameCorticotropin
INNcorticotropin
Description
Corticotropin is a polypeptide hormone produced and secreted by the pituitary gland comprising 39 amino acid residues coupled in a linear sequence. The N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Corticotropin stimulates the cortex of the adrenal gland and boosts the synthesis of corticosteroids, mainly glucocorticoids but also sex steroids (androgens). It is used in the treatment of certain neurological disorders such as infantile spasms and multiple sclerosis, and diagnostically to investigate adrenocortical insufficiency. It has a role as a diagnostic agent. It is a polypeptide, a peptide hormone and a biomacromolecule.
Classification
Protein
Drug classatropine derivatives
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)—
Identifiers
PDB—
CAS-ID9002-60-2
RxCUI376
ChEMBL IDCHEMBL1201610
ChEBI ID—
PubChem CID—
DrugBankDB01285
UNII IDK0U68Q2TXA (ChemIDplus, GSRS)
Target
Agency Approved
MC2R
MC2R
Organism
Homo sapiens
Gene name
MC2R
Gene synonyms
ACTHR
NCBI Gene ID
4158
Protein name
adrenocorticotropic hormone receptor
Protein synonyms
ACTH receptor, Adrenocorticotropin receptor, corticotropin receptor, MC2 receptor, MC2-R, melanocortin 2 receptor (adrenocorticotropic hormone), Melanocortin receptor 2
Uniprot ID
Q504X6
Mouse ortholog
Mc2r (17200)
adrenocorticotropic hormone receptor (Q64326)
Alternate
LINC02210-CRHR1
LINC02210-CRHR1
MC5R
MC5R
MC4R
MC4R
MC1R
MC1R
MC3R
MC3R
CRHR2
CRHR2
Organism
Homo sapiens
Gene name
LINC02210-CRHR1
Gene synonyms
CRFR, CRFR1, CRHR
NCBI Gene ID
104909134
Protein name
CRHR1-IT1-CRHR1 protein
Protein synonyms
Corticotropin-releasing hormone receptor 1, CRH-R-1, CRH-R1, CRHR1-IT1-CRHR1 readthrough
Uniprot ID
B4DMR5
Mouse ortholog
—
—
Variants
No data
Financial
Revenue by drug
$
€
£
₣
No data
Estimated US medical usage
Corticotropin
Total medical expenditures per year (USD, in millions)
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Tabular view
Trends
No data
Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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