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AboutPricing
Drug ReportsColchicine
Colchicine
Colchicine, Gloperba, Lodoco, Mitigare (colchicine) is a small molecule pharmaceutical. Colchicine was first approved as Colbenemid on 1982-01-01. It is used to treat amyloidosis, biliary liver cirrhosis, familial mediterranean fever, and gout in the USA. The pharmaceutical is active against tubulin beta chain. In addition, it is known to target glycine receptor subunit alpha-1, bromodomain-containing protein 4, and glycine receptor subunit alpha-2.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
musculoskeletal diseasesD009140
digestive system diseasesD004066
hereditary congenital and neonatal diseases and abnormalitiesD009358
nutritional and metabolic diseasesD009750
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Colchicine, Gloperba, Mitigare (discontinued: Colcrys)
Combinations
Col-probenecid, Probenecid colchicine (discontinued: Colbenemid, Proben-c, Probenecid colchicine, Probenecid w/ colchicine)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Colchicine
+
Probenecid
Tradename
Company
Number
Date
Products
COLBENEMIDMerck & CoN-012383 DISCN1982-01-01
1 products, RLD
Hide discontinued
Colchicine
Tradename
Company
Number
Date
Products
MITIGAREHikma PharmaceuticalsN-204820 RX2014-09-26
1 products, RLD, RS
GLOPERBAScilex PharmaceuticalsN-210942 RX2019-01-30
1 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
colchicineANDA2025-03-27
colcrysNew Drug Application2023-12-29
gloperbaNew Drug Application2024-11-01
lodocoNew Drug Application2024-08-09
mitigareNew Drug Application2024-05-16
probenecid and colchicineANDA2023-11-06
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
gonorrheaDOID_7551D006069A54
biliary liver cirrhosis—D008105K74.3
amyloidosisEFO_1001875D000686E85
neurosyphilisEFO_0007339D009494A50.40
familial mediterranean fever—D010505M04.1
goutEFO_0004274D006073M10
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Colchicine, Gloperba, Scilex Pharms
102264232037-12-20DP
99077512036-11-22DP
103838202036-11-22DPU-2814
103838212036-11-22DP
Colchicine, Lodoco, Agepha Pharma Fz
97441442035-01-22U-3643
102068912035-01-22U-3641
102652812035-01-22U-3639
108427622035-01-22U-3640
110268992035-01-22U-3639
110269002035-01-22U-3639
110269012035-01-22U-3638
101305852034-12-31U-3642
Colchicine, Mitigare, Hikma Intl Pharms
89276072033-08-22U-1020
93990362033-08-22U-1020
95550292033-08-22U-1020
96756132033-08-22U-1020
97891082033-08-22U-1020
Colchicine, Colcrys, Takeda Pharms Usa
78206812029-02-17U-1020
79065192029-02-17U-1116
79152692029-02-17U-1007
84407212029-02-17U-1007
84407222029-02-17U-1020
76017582029-02-10U-1007
76190042028-12-03U-1020
79357312028-12-03U-1116
79646472028-10-06U-1007
79646482028-10-06U-1161
79819382028-10-06U-1166
80932962028-10-06U-1007
80932972028-10-06U-1161
80932982028-10-06U-1116
80976552028-10-06U-1020
84153952028-10-06U-1007
84153962028-10-06U-1007
ATC Codes
L: Antineoplastic and immunomodulating agents
— L01: Antineoplastic agents
— L01C: Plant alkaloids and other natural products, antineoplastic drugs
— L01CC: Colchicine derivatives, antineooplastic
M: Musculo-skeletal system drugs
— M04: Antigout preparations
— M04A: Antigout preparations
— M04AC: Preparations with no effect on uric acid metabolism
— M04AC01: Colchicine
HCPCS
No data
Clinical
Clinical Trials
300 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Liver cirrhosisD008103EFO_0001422K74.0———1—1
FibrosisD005355—————1—1
Hepatitis cD006526—B19.2———1—1
HepatitisD006505—K75.9———1—1
HepacivirusD016174—————1—1
Hepatitis aD006506EFO_0007305B15———1—1
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameColchicine
INN—
Description
(S)-colchicine is a colchicine that has (S)-configuration. It is a secondary metabolite, has anti-inflammatory properties and is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, and many other conditions. It has a role as a mutagen, an anti-inflammatory agent and a gout suppressant. It is a colchicine and an alkaloid. It is an enantiomer of a (R)-colchicine.
Classification
Small molecule
Drug class—
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
COc1cc2c(c(OC)c1OC)-c1ccc(OC)c(=O)cc1[C@@H](NC(C)=O)CC2
Identifiers
PDB—
CAS-ID64-86-8
RxCUI—
ChEMBL IDCHEMBL107
ChEBI ID27882
PubChem CID6167
DrugBankDB01394
UNII ID—
Target
Agency Approved
TUBB
TUBB
Organism
Homo sapiens
Gene name
TUBB
Gene synonyms
TUBB5
NCBI Gene ID
203068
Protein name
tubulin beta chain
Protein synonyms
beta Ib tubulin, epididymis secretory sperm binding protein, tubulin beta-1 chain, Tubulin beta-5 chain, tubulin, beta polypeptide
Uniprot ID
Q9CY33
Mouse ortholog
Tubb5 (22154)
tubulin beta-5 chain (Q3UF52)
Alternate
GLRA1
GLRA1
BRD4
BRD4
GLRA2
GLRA2
Organism
Homo sapiens
Gene name
GLRA1
Gene synonyms
NCBI Gene ID
2741
Protein name
glycine receptor subunit alpha-1
Protein synonyms
Glycine receptor 48 kDa subunit, Glycine receptor strychnine-binding subunit
Uniprot ID
P23415
Mouse ortholog
Glra1 (14654)
glycine receptor subunit alpha-1 (Q9R0Y7)
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
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Estimated US medical usage
Colchicine
Total medical expenditures per year (USD, in millions)
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Colchicine
+
Probenecid
Total medical expenditures per year (USD, in millions)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 38,281 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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9,397 adverse events reported
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