Colchicine - PharmaKB

Colchicine

Colchicine, Colcrys, Gloperba, Lodoco, Mitigare (colchicine) is a small molecule pharmaceutical. Colchicine was first approved as Colbenemid on 1982-01-01. It is used to treat amyloidosis, biliary liver cirrhosis, familial mediterranean fever, and gout in the USA. The pharmaceutical is active against tubulin beta chain. In addition, it is known to target glycine receptor subunit alpha-1, bromodomain-containing protein 4, and glycine receptor subunit alpha-2.

Download report

Favorite

COVID-19

Events Timeline

Commercial

Clinical

Drug

Target

Variants

Financial

Trends

Safety

Events Timeline

YTD

Max

Events

FDA approval date

EMA approval date

Patent expiration date

Study first post date

Last update post date

Start date

Primary completion date

Completion date

Results first post date

Mock data
Subscribe for the real data

Commercial

Therapeutic Areas

Therapeutic Area	MeSH
musculoskeletal diseases	D009140
digestive system diseases	D004066
hereditary congenital and neonatal diseases and abnormalities	D009358
nutritional and metabolic diseases	D009750
signs and symptoms pathological conditions	D013568

Trade Name

FDA

EMA

Colcrys, Gloperba, Lodoco, Mitigare (generic drugs available since 1982-01-01)

Drug Products

FDA

EMA

New Drug Application (NDA)

Abbreviated New Drug Application (ANDA)

Colchicine

Tradename	Company	Number	Date	Products
LODOCO	AGEPHA PHARMA FZ	N-215727 RX	2023-06-16	1 products, RLD, RS
MITIGARE	Hikma Pharmaceuticals	N-204820 RX	2014-09-26	1 products, RLD, RS
GLOPERBA	Scilex Pharmaceuticals	N-210942 RX	2019-01-30	1 products, RLD, RS
COLCRYS	Takeda	N-022352 RX	2009-07-29	1 products, RLD, RS

Colchicine

Probenecid

Tradename	Company	Number	Date	Products
COLBENEMID	Merck KGaA	N-012383 DISCN	1982-01-01	1 products, RLD

Hide discontinued

Labels

FDA

EMA

Brand Name	Status	Last Update
colchicine	NDA authorized generic	2024-01-10
colcrys	New Drug Application	2023-12-29
gloperba	New Drug Application	2023-12-28
lodoco	New Drug Application	2023-08-24
mitigare	New Drug Application	2023-11-20
probenecid and colchicine	ANDA	2023-11-06

Indications

FDA

EMA

Indication	Ontology	MeSH	ICD-10
amyloidosis	EFO_1001875	D000686	E85
biliary liver cirrhosis	—	D008105	K74.3
familial mediterranean fever	—	D010505	M04.1
gout	EFO_0004274	D006073	M10

Agency Specific

FDA

EMA

No data

Patent Expiration

Patent	Expires	Flag	FDA Information
Colchicine, Gloperba, Scilex Pharms
10226423	2037-12-20	DP
9907751	2036-11-22	DP
10383820	2036-11-22	DP	U-2814
10383821	2036-11-22	DP
Colchicine, Lodoco, Agepha Pharma Fz
9744144	2035-01-22		U-3643
10206891	2035-01-22		U-3641
10265281	2035-01-22		U-3639
10842762	2035-01-22		U-3640
11026899	2035-01-22		U-3639
11026900	2035-01-22		U-3639
11026901	2035-01-22		U-3638
10130585	2034-12-31		U-3642
Colchicine, Mitigare, Hikma Intl Pharms
8927607	2033-08-22		U-1020
9399036	2033-08-22		U-1020
9555029	2033-08-22		U-1020
9675613	2033-08-22		U-1020
9789108	2033-08-22		U-1020
Colchicine, Colcrys, Takeda Pharms Usa
7820681	2029-02-17		U-1020
7906519	2029-02-17		U-1116
7915269	2029-02-17		U-1007
8440721	2029-02-17		U-1007
8440722	2029-02-17		U-1020
7601758	2029-02-10		U-1007
7619004	2028-12-03		U-1020
7935731	2028-12-03		U-1116
7964647	2028-10-06		U-1007
7964648	2028-10-06		U-1161
7981938	2028-10-06		U-1166
8093296	2028-10-06		U-1007
8093297	2028-10-06		U-1161
8093298	2028-10-06		U-1116
8097655	2028-10-06		U-1020
8415395	2028-10-06		U-1007
8415396	2028-10-06		U-1007

ATC Codes

L: Antineoplastic and immunomodulating agents

— L01: Antineoplastic agents

— L01C: Plant alkaloids and other natural products, antineoplastic drugs

— L01CC: Colchicine derivatives, antineooplastic

M: Musculo-skeletal system drugs

— M04: Antigout preparations

— M04A: Antigout preparations

— M04AC: Preparations with no effect on uric acid metabolism

— M04AC01: Colchicine

HCPCS

No data

Clinical

Clinical Trials

273 clinical trials

View more details

Mock data
Subscribe for the real data

Indications Phases 4

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Covid-19	D000086382	—	U07.1	4	12	9	2	7	29
Gout	D006073	EFO_0004274	M10	4	10	2	9	3	28
Coronary artery disease	D003324	—	I25.1	—	4	5	7	1	17
Atrial fibrillation	D001281	EFO_0000275	I48.0	—	3	13	1	1	17
Pharmacokinetics	D010599	—	—	12	—	—	1	—	13
Familial mediterranean fever	D010505	—	M04.1	1	5	1	1	5	13
Acute coronary syndrome	D054058	EFO_0005672	—	—	3	2	5	1	10
Myocardial infarction	D009203	EFO_0000612	I21	—	3	4	1	2	9
Healthy volunteers/patients	—	—	—	7	—	—	2	—	9
Pericarditis	D010493	EFO_0007427	I30	1	1	3	2	—	7

Show 18 more

Indications Phases 3

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Inflammation	D007249	MP_0001845	—	1	5	4	—	1	10
Heart failure	D006333	HP_0001635	I50	—	2	3	—	1	6
Cardiovascular diseases	D002318	HP_0001626	—	—	2	4	—	—	6
Stroke	D020521	EFO_0000712	I63.9	—	—	3	—	—	3
Respiratory distress syndrome	D012128	EFO_1000637	J80	—	—	2	—	—	2
Severe acute respiratory syndrome	D045169	EFO_0000694	J12.81	—	—	2	—	—	2
Cardiac arrhythmias	D001145	EFO_0004269	I49.9	—	—	1	—	1	2
Asthma	D001249	EFO_0000270	J45	—	—	1	—	1	2
Iga vasculitis	D011695	EFO_1000965	D69.0	—	1	1	—	—	2
Heart diseases	D006331	EFO_0003777	I51.9	—	1	2	—	—	2

Show 25 more

Indications Phases 2

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Hyperuricemia	D033461	HP_0002149	—	1	3	—	—	—	4
Diabetic nephropathies	D003928	EFO_0000401	—	1	2	—	—	1	3
Coronavirus infections	D018352	EFO_0007224	B34.2	—	3	—	—	—	3
Behcet syndrome	D001528	EFO_0003780	M35.2	—	2	—	—	1	3
Hypertension	D006973	EFO_0000537	I10	—	1	—	—	1	2
Hepatocellular carcinoma	D006528	—	C22.0	—	2	—	—	—	2
Liver neoplasms	D008113	EFO_1001513	C22.0	—	2	—	—	—	2
Obesity	D009765	EFO_0001073	E66.9	1	2	—	—	—	2
Renal insufficiency	D051437	HP_0000083	N19	—	1	—	—	1	2
Viral pneumonia	D011024	EFO_0007541	J12.9	—	1	—	—	—	1

Show 18 more

Indications Phases 1

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Pneumonia	D011014	EFO_0003106	—	1	—	—	—	1	2
Hypertriglyceridemia	D015228	EFO_0004211	—	1	—	—	—	—	1
Renal replacement therapy	D017582	—	—	1	—	—	—	—	1
Neoplasms	D009369	—	C80	1	—	—	—	—	1
Radiotherapy	D011878	—	—	1	—	—	—	—	1

Indications Without Phase

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Hemorrhage	D006470	MP_0001914	R58	—	—	—	—	1	1
Menorrhagia	D008595	EFO_0003945	N92.0	—	—	—	—	1	1
Hemophilia a	D006467	EFO_0007267	D66	—	—	—	—	1	1
Pain	D010146	EFO_0003843	R52	—	—	—	—	1	1
Down syndrome	D004314	EFO_0001064	Q90	—	—	—	—	1	1
Mucocutaneous lymph node syndrome	D009080	EFO_0004246	M30.3	—	—	—	—	1	1
Hyperaldosteronism	D006929	HP_0011736	E26	—	—	—	—	1	1
Pulmonary arterial hypertension	D000081029	—	—	—	—	—	—	1	1
Urinary tract infections	D014552	EFO_0003103	N39.0	—	—	—	—	1	1
Hyperphosphatemia	D054559	HP_0002905	—	—	—	—	—	1	1

Show 19 more

Epidemiology

Epidemiological information for investigational and approved indications

View more details

Drug

General

Drug common name	Colchicine
INN	—
Description	(S)-colchicine is a colchicine that has (S)-configuration. It is a secondary metabolite, has anti-inflammatory properties and is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, and many other conditions. It has a role as a mutagen, an anti-inflammatory agent and a gout suppressant. It is a colchicine and an alkaloid. It is an enantiomer of a (R)-colchicine.
Classification	Small molecule
Drug class	—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)	COc1cc2c(c(OC)c1OC)-c1ccc(OC)c(=O)cc1[C@@H](NC(C)=O)CC2

Identifiers

PDB	—
CAS-ID	64-86-8
RxCUI	—
ChEMBL ID	CHEMBL107
ChEBI ID	27882
PubChem CID	6167
DrugBank	DB01394
UNII ID	—

Target

Agency Approved

TUBB

Organism

Homo sapiens

Gene name

TUBB

Gene synonyms

TUBB5

NCBI Gene ID

203068

Protein name

tubulin beta chain

Protein synonyms

beta Ib tubulin, epididymis secretory sperm binding protein, tubulin beta-1 chain, Tubulin beta-5 chain, tubulin, beta polypeptide

Uniprot ID

Q9CY33

Mouse ortholog

Tubb5 (22154)

tubulin beta-5 chain (Q3UF52)

Alternate

GLRA1

BRD4

GLRA2

Organism

Homo sapiens

Gene name

GLRA1

Gene synonyms

NCBI Gene ID

2741

Protein name

glycine receptor subunit alpha-1

Protein synonyms

Glycine receptor 48 kDa subunit, Glycine receptor strychnine-binding subunit

Uniprot ID

P23415

Mouse ortholog

Glra1 (14654)

glycine receptor subunit alpha-1 (Q9R0Y7)

Variants

No data

Financial

Revenue by drug

€

₣

No data

Estimated US medical usage

Colchicine

Total medical expenditures per year (USD, in millions)

Mock data
Subscribe for the real data

Number of persons purchased

Mock data
Subscribe for the real data

Number of purchases

Mock data
Subscribe for the real data

Refill frequency

Mock data
Subscribe for the real data

Price per prescription (USD)

Mock data
Subscribe for the real data

Colchicine

Probenecid

Total medical expenditures per year (USD, in millions)

Mock data
Subscribe for the real data

Number of persons purchased

Mock data
Subscribe for the real data

Number of purchases

Mock data
Subscribe for the real data

Refill frequency

Mock data
Subscribe for the real data

Price per prescription (USD)

Mock data
Subscribe for the real data

Tabular view

Trends

PubMed Central

Top Terms for Disease or Syndrome:

Mock data
Subscribe for the real data

Additional graphs summarizing 35,137 documents

View more details

Safety

Black-box Warning

No Black-box warning

Adverse Events

Top Adverse Reactions

Mock data
Subscribe for the real data

6,615 adverse events reported

View more details