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Drug ReportsClozapine
Clozapine
Clozapine, Clozaril, Versacloz (clozapine) is a small molecule pharmaceutical. Clozapine was first approved as Clozaril on 1989-09-26. It is used to treat bipolar disorder, psychotic disorders, schizophrenia, and schizophrenia spectrum and other psychotic disorders in the USA. The pharmaceutical is active against 5-hydroxytryptamine receptor 2A and D(2) dopamine receptor. In addition, it is known to target 5-hydroxytryptamine receptor 2B, alpha-1B adrenergic receptor, muscarinic acetylcholine receptor M1, D(1A) dopamine receptor, D(1B) dopamine receptor, 5-hydroxytryptamine receptor 1E, 5-hydroxytryptamine receptor 5A, 5-hydroxytryptamine receptor 6, D(3) dopamine receptor, 5-hydroxytryptamine receptor 1D, G protein-activated inward rectifier potassium channel 2, histamine H3 receptor, D(4) dopamine receptor, 5-hydroxytryptamine receptor 1F, 5-hydroxytryptamine receptor 1B, 5-hydroxytryptamine receptor 1A, histamine H4 receptor, 5-hydroxytryptamine receptor 2C, 5-hydroxytryptamine receptor 7, histamine H1 receptor, alpha-1A adrenergic receptor, and alpha-1D adrenergic receptor.
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Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
mental disordersD001523
Trade Name
FDA
EMA
Clozapine, Clozaril, Versacloz (discontinued: Clozapine, Clozaril, Fazaclo)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Clozapine
Tradename
Company
Number
Date
Products
VERSACLOZDouglas PharmaceuticalsN-203479 RX2013-02-06
1 products, RLD, RS
CLOZARILHeritage Life Sciences BarbadosN-019758 RX1989-09-26
2 products, RLD, RS
Show 2 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
clozapineANDA2025-01-02
clozarilNew Drug Application2024-11-25
versaclozNew Drug Application2023-03-24
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
schizophreniaEFO_0000692D012559F20
psychotic disorders—D011618F20.81
bipolar disorderEFO_0000289D001714F30.9
schizophrenia spectrum and other psychotic disorders—D019967—
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Clozapine, Versacloz, Tasman Pharma
80578112028-05-01DP
ATC Codes
N: Nervous system drugs
— N05: Psycholeptics
— N05A: Antipsychotics
— N05AH: Diazepines, oxazepines, thiazepines and oxepines antipsychotic drugs
— N05AH02: Clozapine
HCPCS
Code
Description
S0136
Clozapine, 25 mg
Clinical
No data
Drug
General
Drug common nameClozapine
INNclozapine
Description
Clozapine is a psychiatric medication and is the first atypical antipsychotic (also called second-generation antipsychotic) to be discovered. It is primarily used to treat people with schizophrenia and schizoaffective disorder who have had an inadequate response to two other antipsychotics or who have been unable to tolerate other drugs due to extrapyramidal side effects. It is also used for the treatment of psychosis in Parkinson's disease.
Classification
Small molecule
Drug classtricyclic compounds
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CN1CCN(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CC1
Identifiers
PDB—
CAS-ID5786-21-0
RxCUI—
ChEMBL IDCHEMBL42
ChEBI ID3766
PubChem CID2818
DrugBankDB00363
UNII IDJ60AR2IKIC (ChemIDplus, GSRS)
Target
Agency Approved
HTR2A
HTR2A
DRD2
DRD2
Organism
Homo sapiens
Gene name
HTR2A
Gene synonyms
HTR2
NCBI Gene ID
3356
Protein name
5-hydroxytryptamine receptor 2A
Protein synonyms
5-HT2 receptor, 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled, serotonin 5-HT-2A receptor, Serotonin receptor 2A
Uniprot ID
Q5T8C0
Mouse ortholog
Htr2a (15558)
5-hydroxytryptamine receptor 2A (P35363)
Alternate
HTR2B
HTR2B
ADRA1B
ADRA1B
CHRM1
CHRM1
DRD1
DRD1
DRD5
DRD5
HTR1E
HTR1E
HTR5A
HTR5A
HTR6
HTR6
DRD3
DRD3
HTR1D
HTR1D
KCNJ6
KCNJ6
HRH3
HRH3
DRD4
DRD4
HTR1F
HTR1F
HTR1B
HTR1B
HTR1A
HTR1A
HRH4
HRH4
HTR2C
HTR2C
HTR7
HTR7
HRH1
HRH1
ADRA1A
ADRA1A
ADRA1D
ADRA1D
Organism
Homo sapiens
Gene name
HTR2B
Gene synonyms
NCBI Gene ID
3357
Protein name
5-hydroxytryptamine receptor 2B
Protein synonyms
5-HT 2B receptor, 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled, 5-hydroxytryptamine 2B receptor, Serotonin receptor 2B
Uniprot ID
Q6P523
Mouse ortholog
Htr2b (15559)
5-hydroxytryptamine receptor 2B (Q9QWS2)
Variants
No data
Financial
Revenue by drug
$
€
£
₣
Fazaclo – Jazz Pharmaceuticals
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Estimated US medical usage
Clozapine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Trends
No data
Safety
Black-box Warning
Black-box warning for: Clozapine, Clozaril, Versacloz
Adverse Events
0 adverse events reported
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