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Drug ReportsClopidogrel
Plavix, Iscover(clopidogrel)
Clopidogrel, DuoCover, DuoPlavin, Grepid, Iscover, Plavix, Zopya, Zylagren, Zyllt (clopidogrel) is a small molecule pharmaceutical. Clopidogrel was first approved as Plavix on 1997-11-17. It has been approved in Europe to treat acute coronary syndrome, atrial fibrillation, myocardial infarction, peripheral vascular diseases, and stroke. It is known to target P2Y purinoceptor 12.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nervous system diseasesD009422
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Clopidogrel, Plavix (discontinued: Clopidogrel)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Clopidogrel bisulfate
Tradename
Company
Number
Date
Products
PLAVIXSanofiN-020839 RX1997-11-17
2 products, RLD
Labels
FDA
EMA
Brand Name
Status
Last Update
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air sinsin pasOTC monograph final2011-06-06
air sinsinpas-exC2002632024-01-05
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Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
B: Blood and blood forming organ drugs
— B01: Antithrombotic agents
— B01A: Antithrombotic agents
— B01AC: Platelet aggregation inhibitors excl. heparin
— B01AC04: Clopidogrel
HCPCS
Code
Description
G9531
Patient has documentation of ventricular shunt, brain tumor, multisystem trauma, or is currently taking an antiplatelet medication including: abciximab, anagrelide, cangrelor, cilostazol, clopidogrel, dipyridamole, eptifibatide, prasugrel, ticlopidine, ticagrelor, tirofiban, or vorapaxar
Clinical
Clinical Trials
1912 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Multiple sclerosisD009103EFO_0003885G35———1—1
SclerosisD012598—————1—1
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameClopidogrel
INNclopidogrel
Description
Clopidogrel is a thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group, the methylene hydrogen of which is replaced by a methoxycarbonyl group (the S enantiomer). A P2Y12 receptor antagonist, it is used to inhibit blood clots and prevent heart attacks. It has a role as a platelet aggregation inhibitor, an anticoagulant and a P2Y12 receptor antagonist. It is a thienopyridine, a member of monochlorobenzenes and a methyl ester. It is functionally related to a ticlopidine.
Classification
Small molecule
Drug classplatelet aggregation inhibitors, primarily platelet P2Y12 receptor antagonists
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
COC(=O)[C@H](c1ccccc1Cl)N1CCc2sccc2C1
Identifiers
PDB—
CAS-ID113665-84-2
RxCUI—
ChEMBL IDCHEMBL1771
ChEBI ID37941
PubChem CID60606
DrugBankDB00758
UNII IDA74586SNO7 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
P2RY12
P2RY12
Organism
Homo sapiens
Gene name
P2RY12
Gene synonyms
HORK3
NCBI Gene ID
64805
Protein name
P2Y purinoceptor 12
Protein synonyms
ADP-glucose receptor, ADPG-R, G-protein coupled receptor SP1999, Gi-coupled ADP receptor HORK3, P2T(AC), P2Y(AC), P2Y(ADP), P2Y(cyc), P2Y12 platelet ADP receptor, purinergic receptor P2RY12, purinergic receptor P2Y, G-protein coupled, 12, putative G-protein coupled receptor, SP1999
Uniprot ID
Q9H244
Mouse ortholog
P2ry12 (70839)
P2Y purinoceptor 12 (Q9CPV9)
Variants
No data
Financial
Revenue by drug
$
€
£
₣
Plavix – Bristol Myers Squibb
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Plavix – Sanofi
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Tabular view
Estimated US medical usage
Clopidogrel
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 745,204 documents
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Safety
Black-box Warning
Black-box warning for: Aptensio xr, Clopidogrel, Clopidogrel 75mg, Clopidogrel bisulfate, Clopidogrel kit, Clopidrogrel, Concerta, Cotempla xr-odt, Covaryx, Covaryx covaryx, Daytrana, Diclovix, Diclovix m, Dyural 40 kit, Dyural 80 kit, Dyural 80-lm, Dyural lm kit, Eemt, Eemt eemt, Esterified estrogens and methyltestosterone, Estratest f.s., Estratest f.s. estratest h.s., Fenovar, Healthy mamabe well rounded, Hycodan, Hydrocodone bitartrate and homatropine methylbromide, Hydromet, Jornay pm, Metadate cd, Metadate er, Methylene blue, Methylene blue inj, Methylin, Methylphenidate, Methylphenidate hydrochloride, Methylphenidate hydrochloride (la), Methylphenidate hydrochloride extended release, Methylphenidate transdermal system, Perseris, Physicians ez use m-pred, Plavix, Prenate elite, Prenate essential, Provayblue, Quillichew er, Quillivant, Relexxii, Ritalin, Varophen
Adverse Events
Top Adverse Reactions
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71,081 adverse events reported
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