Plavix, Iscover(clopidogrel)
Clopidogrel, DuoCover, DuoPlavin, Grepid, Iscover, Plavix, Zopya, Zylagren, Zyllt (clopidogrel) is a small molecule pharmaceutical. Clopidogrel was first approved as Plavix on 1997-11-17. It has been approved in Europe to treat acute coronary syndrome, atrial fibrillation, myocardial infarction, peripheral vascular diseases, and stroke. It is known to target P2Y purinoceptor 12.
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Commercial
Therapeutic Areas
Trade Name
FDA
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Plavix (generic drugs available since 2008-01-14)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| 1st medxpatch | OTC monograph not final | 2023-09-28 |
| arth arrest | C200263 | 2023-11-11 |
| arth rx topical analgesic | C200263 | 2023-11-06 |
| arthmed topical analgesic | C200263 | 2023-11-11 |
| arthritis pain relief | OTC monograph not final | 2023-10-03 |
| atomic balm | C200263 | 2023-11-05 |
| clopidogrel | ANDA | 2024-01-30 |
| clopidogrel bisulfate | ANDA | 2024-01-12 |
| clopidogrel kit | ANDA | 2017-07-13 |
| clopidrogrel | ANDA | 2016-02-03 |
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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HCPCS
Code | Description |
|---|---|
| G9531 | Patient has documentation of ventricular shunt, brain tumor, multisystem trauma, or is currently taking an antiplatelet medication including: abciximab, anagrelide, cangrelor, cilostazol, clopidogrel, dipyridamole, eptifibatide, prasugrel, ticlopidine, ticagrelor, tirofiban, or vorapaxar |
Clinical
Clinical Trials
1820 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Coronary artery disease | D003324 | — | I25.1 | 8 | 22 | 30 | 116 | 80 | 250 |
| Acute coronary syndrome | D054058 | EFO_0005672 | — | 8 | 16 | 27 | 58 | 48 | 155 |
| Healthy volunteers/patients | — | — | — | 62 | 3 | — | 4 | 12 | 81 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | 3 | 7 | 16 | 29 | 18 | 70 |
| Stroke | D020521 | EFO_0000712 | I63.9 | 4 | 8 | 16 | 18 | 25 | 67 |
| Ischemic stroke | D000083242 | — | — | 3 | 6 | 20 | 15 | 26 | 65 |
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | — | 2 | 9 | 26 | 19 | 55 |
| Coronary disease | D003327 | — | — | — | 2 | 3 | 24 | 14 | 42 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | 7 | 4 | 4 | 13 | 14 | 42 |
| Percutaneous coronary intervention | D062645 | — | — | 1 | 6 | 9 | 15 | 13 | 41 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 14 | 11 | 1 | — | 3 | 20 |
| Prostatic neoplasms | D011471 | — | C61 | 4 | 9 | 3 | — | 1 | 15 |
| Basal cell neoplasms | D018295 | — | — | 1 | 3 | 6 | — | 3 | 11 |
| Adenocarcinoma | D000230 | — | — | — | 6 | 4 | — | — | 9 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 6 | 3 | 1 | — | — | 8 |
| Glioblastoma | D005909 | EFO_0000515 | — | 6 | 1 | 1 | — | — | 7 |
| Lymphoma | D008223 | — | C85.9 | 3 | 4 | 1 | — | — | 6 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | — | 2 | 1 | — | 3 | 6 |
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | — | 1 | — | 4 | 5 |
| Cerebral hemorrhage | D002543 | — | — | — | 1 | 2 | — | 2 | 5 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 12 | 6 | — | — | 5 | 22 |
| Depression | D003863 | — | F33.9 | 3 | 4 | — | — | 4 | 11 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 4 | 6 | — | — | 2 | 10 |
| Venous thrombosis | D020246 | HP_0004936 | I82.40 | — | 1 | — | — | 7 | 8 |
| Pain | D010146 | EFO_0003843 | R52 | 3 | 2 | — | — | 4 | 8 |
| Myelodysplastic syndromes | D009190 | — | D46 | 4 | 5 | — | — | — | 7 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 4 | 3 | — | — | 1 | 7 |
| Colorectal neoplasms | D015179 | — | — | 3 | 4 | — | — | 1 | 6 |
| Multiple myeloma | D009101 | — | C90.0 | 5 | 1 | — | — | — | 6 |
| Obsessive-compulsive disorder | D009771 | EFO_0004242 | F42 | — | 4 | — | — | 2 | 6 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart disease risk factors | D000082742 | — | — | 3 | — | — | — | 1 | 4 |
| Hemostasis | D006487 | — | — | 2 | — | — | — | 2 | 4 |
| Asymptomatic diseases | D058070 | — | — | 1 | — | — | — | 3 | 4 |
| Pharmacokinetics | D010599 | — | — | 3 | — | — | — | — | 3 |
| Vasoconstriction | D014661 | — | — | 3 | — | — | — | — | 3 |
| Shoulder pain | D020069 | HP_0030834 | M25.51 | 1 | — | — | — | 2 | 3 |
| Disease | D004194 | EFO_0000408 | R69 | 3 | — | — | — | — | 3 |
| Bacterial infections | D001424 | — | A49 | 1 | — | — | — | 1 | 2 |
| Hypercholesterolemia | D006937 | HP_0003124 | — | 1 | — | — | — | 1 | 2 |
| Contraception | D003267 | — | — | 2 | — | — | — | — | 2 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Carotid artery diseases | D002340 | EFO_0003781 | — | — | — | — | — | 8 | 8 |
| Hip fractures | D006620 | EFO_0003964 | S72.00 | — | — | — | — | 5 | 5 |
| Drug resistance | D004351 | — | Z16.30 | — | — | — | — | 4 | 4 |
| Cystic fibrosis | D003550 | EFO_0000390 | E84 | — | — | — | — | 4 | 4 |
| Sarcopenia | D055948 | EFO_1000653 | M62.84 | — | — | — | — | 3 | 3 |
| Subarachnoid hemorrhage | D013345 | EFO_0000713 | I60 | — | — | — | — | 2 | 2 |
| Surgical blood loss | D016063 | — | — | — | — | — | — | 2 | 2 |
| Aneurysm | D000783 | HP_0002617 | I72.9 | — | — | — | — | 2 | 2 |
| Brain ischemia | D002545 | EFO_0003883 | I67.82 | — | — | — | — | 2 | 2 |
| Peptic ulcer hemorrhage | D010438 | — | — | — | — | — | — | 2 | 2 |
Show 118 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Clopidogrel |
| INN | clopidogrel |
| Description | Clopidogrel is a thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group, the methylene hydrogen of which is replaced by a methoxycarbonyl group (the S enantiomer). A P2Y12 receptor antagonist, it is used to inhibit blood clots and prevent heart attacks. It has a role as a platelet aggregation inhibitor, an anticoagulant and a P2Y12 receptor antagonist. It is a thienopyridine, a member of monochlorobenzenes and a methyl ester. It is functionally related to a ticlopidine. |
| Classification | Small molecule |
| Drug class | platelet aggregation inhibitors, primarily platelet P2Y12 receptor antagonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COC(=O)[C@H](c1ccccc1Cl)N1CCc2sccc2C1 |
Identifiers
| PDB | — |
| CAS-ID | 113665-84-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1771 |
| ChEBI ID | 37941 |
| PubChem CID | 60606 |
| DrugBank | DB00758 |
| UNII ID | A74586SNO7 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
P2RY12
P2RY12
Organism
Homo sapiens
Gene name
P2RY12
Gene synonyms
HORK3
NCBI Gene ID
Protein name
P2Y purinoceptor 12
Protein synonyms
ADP-glucose receptor, ADPG-R, G-protein coupled receptor SP1999, Gi-coupled ADP receptor HORK3, P2T(AC), P2Y(AC), P2Y(ADP), P2Y(cyc), P2Y12 platelet ADP receptor, purinergic receptor P2RY12, purinergic receptor P2Y, G-protein coupled, 12, putative G-protein coupled receptor, SP1999
Uniprot ID
Mouse ortholog
P2ry12 (70839)
P2Y purinoceptor 12 (Q9CPV9)
Variants
No data
Financial
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Plavix – Bristol Myers Squibb
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Plavix – Sanofi
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Estimated US medical usage
Clopidogrel
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 790,688 documents
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Safety
Black-box Warning
Black-box warning for: Clopidogrel, Clopidogrel bisulfate, Clopidogrel kit, Clopidrogrel, Dfs 1.5%/ms 25%/menth 6%/cap 0.025% pak, Dfs 75mg dr/ms 25%/menth 6%/cap 0.025% pak, Diclovix, Diclovix m, Dyural 40 kit, Dyural 80 kit, Dyural 80-lm, Dyural lm kit, Healthy mamabe well rounded, Nudroxipak, Nudroxipak dsdr-50, Nudroxipak dsdr-75, Nudroxipak e-400, Nudroxipak i-800, Nudroxipak m-15, Nudroxipak n-500, Physicians ez use m-pred, Plavix, Prenate elite, Prenate essential, Varophen
Adverse Events
Top Adverse Reactions
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233,232 adverse events reported
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