Plavix, Iscover(clopidogrel)
Clopidogrel, DuoCover, DuoPlavin, Grepid, Iscover, Plavix, Zopya, Zylagren, Zyllt (clopidogrel) is a small molecule pharmaceutical. Clopidogrel was first approved as Plavix on 1997-11-17. It has been approved in Europe to treat acute coronary syndrome, atrial fibrillation, myocardial infarction, peripheral vascular diseases, and stroke. It is known to target P2Y purinoceptor 12.
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Clopidogrel, Plavix (discontinued: Clopidogrel)
Labels
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EMA
Brand Name | Status | Last Update |
|---|---|---|
| 10% methyl salicylate pain relief patch | C200263 | 2024-06-27 |
| 1st medxpatch | unapproved drug other | 2025-10-31 |
| 365 whole foods market anticavity/antigingivitis mouthwash | OTC monograph not final | 2022-05-12 |
| 5kind dmso | C200263 | 2025-12-02 |
| 701 dieda zhengtong yaogao medicated | OTC monograph not final | 2019-11-13 |
| 701 dieda zhengtong yaogao medicated plaster | OTC monograph not final | 2014-06-26 |
| abejas y viboras roll on | C200263 | 2025-07-22 |
| absolut skin spf 50 moisturizing sunscreen | C200263 | 2025-06-19 |
| advanced antiseptic citrus | C200263 | 2025-02-20 |
| advanced citrus antiseptic | C200263 | 2025-01-10 |
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Agency Specific
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HCPCS
Code | Description |
|---|---|
| G9531 | Patient has documentation of ventricular shunt, brain tumor, multisystem trauma, or is currently taking an antiplatelet medication including: abciximab, anagrelide, cangrelor, cilostazol, clopidogrel, dipyridamole, eptifibatide, prasugrel, ticlopidine, ticagrelor, tirofiban, or vorapaxar |
Clinical
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3045 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Coronary artery disease | D003324 | — | I25.1 | 11 | 28 | 36 | 143 | 102 | 313 |
| Acute coronary syndrome | D054058 | EFO_0005672 | — | 11 | 19 | 35 | 68 | 55 | 184 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | 5 | 12 | 27 | 61 | 39 | 137 |
| Stroke | D020521 | EFO_0000712 | I63.9 | 6 | 15 | 39 | 30 | 51 | 133 |
| Healthy volunteers/patients | — | — | — | 102 | 6 | — | 7 | 18 | 132 |
| Coronary disease | D003327 | — | — | 1 | 12 | 9 | 54 | 45 | 117 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | 1 | 13 | 10 | 52 | 44 | 116 |
| Ischemic stroke | D000083242 | — | — | 4 | 13 | 39 | 25 | 36 | 110 |
| Infarction | D007238 | EFO_0009463 | — | 5 | 8 | 16 | 46 | 35 | 105 |
| Syndrome | D013577 | — | — | — | 11 | 14 | 30 | 31 | 84 |
Show 379 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | 7 | 13 | 1 | — | 3 | 24 |
| Lymphoma | D008223 | — | C85.9 | 9 | 8 | 1 | — | — | 14 |
| Leukemia | D007938 | — | C95 | 6 | 6 | 2 | — | 2 | 12 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 10 | 4 | 1 | — | — | 12 |
| Glioblastoma | D005909 | EFO_0000515 | — | 10 | 2 | 1 | — | 1 | 12 |
| Overactive urinary bladder | D053201 | EFO_1000781 | N32.81 | 3 | 2 | 5 | — | 2 | 11 |
| Cough | D003371 | — | R05 | 1 | 4 | 3 | — | 2 | 10 |
| Asthma | D001249 | EFO_0000270 | J45 | 4 | 4 | 1 | — | 2 | 10 |
| Basal cell neoplasms | D018295 | — | — | 1 | 3 | 5 | — | 3 | 10 |
| Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 3 | 4 | 3 | — | 2 | 9 |
Show 141 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 4 | 8 | — | — | 1 | 11 |
| Atopic dermatitis | D003876 | EFO_0000274 | L20 | 2 | 9 | — | — | — | 10 |
| Head and neck neoplasms | D006258 | — | — | 3 | 5 | — | — | 1 | 9 |
| Obstructive lung diseases | D008173 | — | — | 3 | 5 | — | — | 1 | 9 |
| Gastroparesis | D018589 | EFO_1000948 | K31.84 | 3 | 6 | — | — | — | 9 |
| Myelodysplastic syndromes | D009190 | — | D46 | 6 | 5 | — | — | — | 8 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 5 | 4 | — | — | — | 8 |
| Multiple myeloma | D009101 | — | C90.0 | 6 | 2 | — | — | — | 8 |
| Alcoholism | D000437 | EFO_0003829 | F10.1 | 3 | 2 | — | — | 3 | 8 |
| Dermatitis | D003872 | — | L30.9 | 2 | 7 | — | — | — | 8 |
Show 211 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sleep wake disorders | D012893 | — | G47 | 2 | — | — | — | 4 | 6 |
| Aging | D000375 | GO_0007568 | R41.81 | 1 | — | — | — | 5 | 6 |
| Asymptomatic diseases | D058070 | — | — | 1 | — | — | — | 5 | 6 |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | 3 | — | — | — | 3 | 6 |
| Hemostasis | D006487 | — | — | 2 | — | — | — | 3 | 5 |
| Therapeutic equivalency | D013810 | — | — | 4 | — | — | — | — | 4 |
| Heart disease risk factors | D000082742 | — | — | 3 | — | — | — | 1 | 4 |
| Pharmacokinetics | D010599 | — | — | 4 | — | — | — | — | 4 |
| Hepatic insufficiency | D048550 | — | — | 3 | — | — | — | — | 3 |
| Fasting | D005215 | EFO_0002756 | — | 3 | — | — | — | — | 3 |
Show 69 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Carotid artery diseases | D002340 | EFO_0003781 | — | — | — | — | — | 8 | 8 |
| Surgical blood loss | D016063 | — | — | — | — | — | — | 6 | 6 |
| Sarcopenia | D055948 | EFO_1000653 | M62.84 | — | — | — | — | 6 | 6 |
| Brain ischemia | D002545 | EFO_0003883 | I67.82 | — | — | — | — | 5 | 5 |
| Drug resistance | D004351 | — | Z16.30 | — | — | — | — | 4 | 4 |
| Deglutition disorders | D003680 | — | R13.1 | — | — | — | — | 3 | 3 |
| Blood coagulation disorders | D001778 | EFO_0009314 | D68.9 | — | — | — | — | 3 | 3 |
| Hemostatic disorders | D020141 | — | — | — | — | — | — | 3 | 3 |
| Cardiopulmonary bypass | D002315 | — | — | — | — | — | — | 3 | 3 |
| Trigger finger disorder | D052582 | — | M65.3 | — | — | — | — | 3 | 3 |
Show 261 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Clopidogrel |
| INN | clopidogrel |
| Description | Clopidogrel is a thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group, the methylene hydrogen of which is replaced by a methoxycarbonyl group (the S enantiomer). A P2Y12 receptor antagonist, it is used to inhibit blood clots and prevent heart attacks. It has a role as a platelet aggregation inhibitor, an anticoagulant and a P2Y12 receptor antagonist. It is a thienopyridine, a member of monochlorobenzenes and a methyl ester. It is functionally related to a ticlopidine. |
| Classification | Small molecule |
| Drug class | platelet aggregation inhibitors, primarily platelet P2Y12 receptor antagonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COC(=O)[C@H](c1ccccc1Cl)N1CCc2sccc2C1 |
Identifiers
| PDB | — |
| CAS-ID | 113665-84-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1771 |
| ChEBI ID | 37941 |
| PubChem CID | 60606 |
| DrugBank | DB00758 |
| UNII ID | A74586SNO7 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
P2RY12
P2RY12
Organism
Homo sapiens
Gene name
P2RY12
Gene synonyms
HORK3
NCBI Gene ID
Protein name
P2Y purinoceptor 12
Protein synonyms
ADP-glucose receptor, ADPG-R, G-protein coupled receptor SP1999, Gi-coupled ADP receptor HORK3, P2T(AC), P2Y(AC), P2Y(ADP), P2Y(cyc), P2Y12 platelet ADP receptor, purinergic receptor P2RY12, purinergic receptor P2Y, G-protein coupled, 12, putative G-protein coupled receptor, SP1999
Uniprot ID
Mouse ortholog
P2ry12 (70839)
P2Y purinoceptor 12 (Q9CPV9)
Variants
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Financial
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Plavix – Bristol Myers Squibb
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Plavix – Sanofi
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Bloxiverz – Avadel Pharmaceuticals
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Daytrana – Shire
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Concerta – Johnson & Johnson
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Medrol – Pfizer
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Methylphenidate – RVL Pharmaceuticals
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Estimated US medical usage
Clopidogrel
Total medical expenditures per year (USD, in millions)
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Safety
Black-box Warning
Black-box warning for: Aptensio xr, Clopidogrel, Clopidogrel 75mg, Clopidogrel bisulfate, Clopidogrel kit, Clopidrogrel, Concerta, Cotempla xr-odt, Covaryx, Covaryx covaryx, Daytrana, Diclovix m, Dyural 40 kit, Dyural 80 kit, Dyural 80-lm, Dyural lm kit, Eemt, Eemt eemt, Esterified estrogens and methyltestosterone, Esterified estrogens and methyltestosterone full strength esterified estrogens and methyltestosterone half strength, Estratest f.s., Estratest f.s. estratest h.s., Estratest fs estratest hs, Fenovar, Healthy mamabe well rounded, Hycodan, Hydrocodone bitartrate and homatropine methylbromide, Hydromet, Jornay pm, Metadate cd, Metadate er, Methylene blue, Methylin, Methylphenidate, Methylphenidate hydrochloride, Methylphenidate hydrochloride (la), Methylphenidate hydrochloride cd, Methylphenidate hydrochloride extended release, Methylphenidate transdermal system, Orthaphen, Perseris, Physicians ez use m-pred, Plavix, Prenate elite, Prenate essential, Provayblue, Quillichew er, Quillivant, Relexxii, Ritalin, Varophen
Adverse Events
Top Adverse Reactions
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315,021 adverse events reported
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