Plavix, Iscover(clopidogrel)
Clopidogrel, DuoCover, DuoPlavin, Grepid, Iscover, Plavix, Zopya, Zylagren, Zyllt (clopidogrel) is a small molecule pharmaceutical. Clopidogrel was first approved as Plavix on 1997-11-17. It has been approved in Europe to treat acute coronary syndrome, atrial fibrillation, myocardial infarction, peripheral vascular diseases, and stroke. It is known to target P2Y purinoceptor 12.
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Commercial
Therapeutic Areas
Trade Name
FDA
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Clopidogrel, Plavix (discontinued: Clopidogrel)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| 10% methyl salicylate pain relief patch | C200263 | 2024-06-27 |
| 1st medxpatch | unapproved drug other | 2026-08-11 |
| 365 whole foods market anticavity/antigingivitis mouthwash | OTC monograph not final | 2022-05-12 |
| 5kind dmso | C200263 | 2025-12-02 |
| 701 dieda zhengtong yaogao medicated | OTC monograph not final | 2019-11-13 |
| 701 dieda zhengtong yaogao medicated plaster | OTC monograph not final | 2014-06-26 |
| abejas y viboras roll on | C200263 | 2025-07-22 |
| absolut skin spf 50 moisturizing sunscreen | C200263 | 2025-12-22 |
| advanced antiseptic citrus | C200263 | 2025-02-20 |
| advanced citrus antiseptic | C200263 | 2025-01-10 |
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Agency Specific
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Patent Expiration
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HCPCS
Code | Description |
|---|---|
| G9531 | Patient has documentation of ventricular shunt, brain tumor, multisystem trauma, or is currently taking an antiplatelet medication including: abciximab, anagrelide, cangrelor, cilostazol, clopidogrel, dipyridamole, eptifibatide, prasugrel, ticlopidine, ticagrelor, tirofiban, or vorapaxar |
Clinical
Clinical Trials
3188 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | 2 | 3 | 4 | — | 8 |
| Coronary artery disease | D003324 | — | I25.1 | — | — | — | 3 | 2 | 5 |
| Acute coronary syndrome | D054058 | EFO_0005672 | — | — | — | 2 | 2 | — | 4 |
| Infarction | D007238 | EFO_0009463 | — | — | 1 | 2 | 2 | — | 4 |
| Platelet aggregation | D010974 | GO_0070527 | — | — | — | 1 | 1 | — | 2 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | — | — | 1 | 1 | 2 |
| Metabolic syndrome | D024821 | EFO_0000195 | E88.810 | — | — | — | 1 | 1 | 2 |
| Inferior wall myocardial infarction | D056989 | EFO_1000983 | — | — | — | — | 2 | — | 2 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | 2 | — | 2 |
| Peripheral arterial disease | D058729 | EFO_0004265 | — | — | — | 1 | 1 | — | 2 |
Show 6 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Thrombosis | D013927 | — | — | — | 1 | 3 | — | — | 4 |
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | — | — | 3 | — | — | 3 |
| Congenital heart defects | D006330 | — | Q24.9 | — | 1 | 2 | — | — | 3 |
| Vascular diseases | D014652 | EFO_0004264 | I77 | — | — | 2 | — | — | 2 |
| Embolism | D004617 | — | — | — | — | 2 | — | — | 2 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | — | 1 | — | — | 1 |
| Unstable angina | D000789 | EFO_1000985 | I20.0 | — | — | 1 | — | — | 1 |
| Transient ischemic attack | D002546 | EFO_0003764 | G45.9 | — | — | 1 | — | — | 1 |
| Brain infarction | D020520 | EFO_0004277 | I63 | — | — | 1 | — | — | 1 |
| Arterial occlusive diseases | D001157 | EFO_0009085 | — | — | — | 1 | — | — | 1 |
Show 4 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Blood platelet disorders | D001791 | — | — | — | 1 | — | — | 1 | 2 |
| Atherosclerosis | D050197 | EFO_0003914 | I25.1 | — | 1 | — | — | 1 | 2 |
| Percutaneous coronary intervention | D062645 | — | — | — | 1 | — | — | — | 1 |
| Ischemia | D007511 | EFO_0000556 | — | — | 1 | — | — | — | 1 |
| Intermittent claudication | D007383 | EFO_0003876 | I73.9 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 7 | — | — | — | — | 7 |
| Drug interactions | D004347 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Syndrome | D013577 | — | — | — | — | — | — | 1 | 1 |
| Hematologic neoplasms | D019337 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Clopidogrel |
| INN | clopidogrel |
| Description | Clopidogrel is a thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group, the methylene hydrogen of which is replaced by a methoxycarbonyl group (the S enantiomer). A P2Y12 receptor antagonist, it is used to inhibit blood clots and prevent heart attacks. It has a role as a platelet aggregation inhibitor, an anticoagulant and a P2Y12 receptor antagonist. It is a thienopyridine, a member of monochlorobenzenes and a methyl ester. It is functionally related to a ticlopidine. |
| Classification | Small molecule |
| Drug class | platelet aggregation inhibitors, primarily platelet P2Y12 receptor antagonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COC(=O)[C@H](c1ccccc1Cl)N1CCc2sccc2C1 |
Identifiers
| PDB | — |
| CAS-ID | 113665-84-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1771 |
| ChEBI ID | 37941 |
| PubChem CID | 60606 |
| DrugBank | DB00758 |
| UNII ID | A74586SNO7 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
P2RY12
P2RY12
Organism
Homo sapiens
Gene name
P2RY12
Gene synonyms
HORK3
NCBI Gene ID
Protein name
P2Y purinoceptor 12
Protein synonyms
ADP-glucose receptor, ADPG-R, G-protein coupled receptor SP1999, Gi-coupled ADP receptor HORK3, P2T(AC), P2Y(AC), P2Y(ADP), P2Y(cyc), P2Y12 platelet ADP receptor, purinergic receptor P2RY12, purinergic receptor P2Y, G-protein coupled, 12, putative G-protein coupled receptor, SP1999
Uniprot ID
Mouse ortholog
P2ry12 (70839)
P2Y purinoceptor 12 (Q9CPV9)
Variants
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Concerta – Johnson & Johnson
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Plavix – Bristol Myers Squibb
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Plavix – Sanofi
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Bloxiverz – Avadel Pharmaceuticals
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Daytrana – Shire
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Medrol – Pfizer
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Estimated US medical usage
Clopidogrel
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Safety
Black-box Warning
Black-box warning for: Clopidogrel, Clopidogrel 75mg, Clopidogrel bisulfate, Clopidogrel kit, Clopidrogrel, Concerta, Cotempla xr-odt, Covaryx, Covaryx covaryx, Daytrana, Diclovix m, Dyural 40 kit, Dyural 80 kit, Dyural 80-lm, Dyural lm kit, Eemt, Eemt eemt, Esterified estrogens and methyltestosterone, Esterified estrogens and methyltestosterone full strength esterified estrogens and methyltestosterone half strength, Estratest f.s., Estratest f.s. estratest h.s., Estratest fs estratest hs, Fenovar, Healthy mamabe well rounded, Hydrocodone bitartrate and homatropine methylbromide, Jornay pm, Metadate cd, Metadate er, Methylene blue, Methylin, Methylphenidate, Methylphenidate extended-release, Methylphenidate hydrochloride, Methylphenidate hydrochloride (la), Methylphenidate hydrochloride cd, Methylphenidate hydrochloride extended release, Methylphenidate transdermal system, Orthaphen, Orthrexo, Perseris, Physicians ez use m-pred, Plavix, Provayblue, Quillichew er, Quillivant, Relexxii, Ritalin, Torvex, Torvexa, Varophen
Adverse Events
Top Adverse Reactions
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325,752 adverse events reported
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