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Drug ReportsCiprofloxacin
Ciprofloxacin
Cetraxal, Ciloxan, Cipro, Ciprodex, Ciprofloxacin, Ciprofloxacin /, Ciprofloxacin / Ciprofloxacin, Otovel (ciprofloxacin) is a small molecule pharmaceutical. Ciprofloxacin was first approved as Cipro on 1987-10-22. It is used to treat anthrax, bacterial conjunctivitis, bacterial infections, bacterial skin diseases, and bacteroides infections amongst others in the USA.
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Novartis Pharmaceuticals
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
musculoskeletal diseasesD009140
digestive system diseasesD004066
respiratory tract diseasesD012140
otorhinolaryngologic diseasesD010038
eye diseasesD005128
urogenital diseasesD000091642
hemic and lymphatic diseasesD006425
skin and connective tissue diseasesD017437
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Cetraxal, Ciloxan, Cipro, Ciprofloxacin (discontinued: Cipro, Ciprofloxacin, Otiprio, Proquin)
Combinations
Cipro, Ciprodex, Ciprofloxacin, Ciprofloxacin dexamethasone, Ciprofloxacin; dexamethasone, Otovel (discontinued: Cipro, Ciprofloxacin)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Ciprofloxacin hydrochloride
Tradename
Company
Number
Date
Products
CIPROBayerN-019537 RX1987-10-22
2 products, RLD, RS
CETRAXALKey TherapeuticsN-021918 RX2009-05-01
1 products, RLD, RS
CILOXANSandozN-019992 RX1990-12-31
1 products, RLD, RS
CILOXANSandozN-020369 RX1998-03-30
1 products, RLD, RS
Show 2 discontinued
Ciprofloxacin
Tradename
Company
Number
Date
Products
CIPROBayerN-020780 RX1997-09-26
2 products, RLD, RS
Show 4 discontinued
Ciprofloxacin
+
Ciprofloxacin hydrochloride
Tradename
Company
Number
Date
Products
CIPRO XRBayerN-021473 DISCN2002-12-13
2 products
Hide discontinued
Ciprofloxacin hydrochloride
+
Fluocinolone acetonide
Tradename
Company
Number
Date
Products
OTOVELLaboratorios SalvatN-208251 RX2016-04-29
1 products, RLD, RS
Ciprofloxacin hydrochloride
+
Hydrocortisone
Tradename
Company
Number
Date
Products
CIPRO HCSandozN-020805 RX1998-02-10
1 products, RLD, RS
Ciprofloxacin
+
Dexamethasone
Tradename
Company
Number
Date
Products
CIPRODEXSandozN-021537 RX2003-07-18
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
cetraxalNew Drug Application2024-10-09
ciloxanNew Drug Application2023-06-27
ciproNew Drug Application2024-11-08
cipro hcNew Drug Application2009-10-27
ciprodexNew Drug Application2023-06-26
ciprofloxacinANDA2025-02-07
ciprofloxacin and dexamethasoneANDA2024-11-01
ciprofloxacin and fluocinolone acetonideNDA authorized generic2024-10-09
ciprofloxacin hclANDA2024-12-31
ciprofloxacin hcl ophthalmicANDA2022-10-28
Show 7 more
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
neutropenia—D009503D70
prostatitisEFO_0003830D011472N41
fever—D005334R50.9
urinary tract infectionsEFO_0003103D014552N39.0
sinusitisEFO_0007486D012852J32
typhoid feverEFO_0006789D014435A01.0
diarrhea—D003967R19.7
bacterial infections—D001424A49
gonorrheaDOID_7551D006069A54
intraabdominal infections—D059413—
Show 57 more
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Ciprofloxacin, Otiprio, Alk Abello
112468632038-11-27DP
110400042037-11-12U-2252
92207962035-07-01DP
83188172030-04-27U-1792
92330682029-12-11DP
92050482029-04-21U-1793
96037962029-04-21DS, DPU-2252
113695662029-04-21DP
Ciprofloxacin Hydrochloride / Fluocinolone Acetonide, Otovel, Laboratorios Salvat
89326102030-03-24DPU-1578
Ciprofloxacin / Dexamethasone, Ciprodex, Sandoz
88466502025-06-04DPU-1578
ATC Codes
J: Antiinfectives for systemic use
— J01: Antibacterials for systemic use
— J01M: Quinolone antibacterials
— J01MA: Fluoroquinolone antibacterials, systemic
— J01MA02: Ciprofloxacin
— J01R: Combinations of antibacterials
— J01RA: Combinations of antibacterials
— J01RA10: Ciprofloxacin and metronidazole
— J01RA11: Ciprofloxacin and tinidazole
— J01RA12: Ciprofloxacin and ornidazole
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01A: Antiinfective ophthalmologics
— S01AE: Fluoroquinolone antiinfectives, ophthalmologic
— S01AE03: Ciprofloxacin
— S02: Otologicals
— S02A: Antiinfective drugs, otologic
— S02AA: Antiinfectives
— S02AA15: Ciprofloxacin
— S03: Ophthalmological and otological preparations
— S03A: Antiinfectives, ophthalmologic and otologic
— S03AA: Antiinfectives
— S03AA07: Ciprofloxacin
HCPCS
Code
Description
J0744
Injection, ciprofloxacin for intravenous infusion, 200 mg
J7342
Instillation, ciprofloxacin otic suspension, 6 mg
Clinical
Clinical Trials
410 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Corneal ulcerD003320—H16.0—1———1
KeratitisD007634—H16—1———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCiprofloxacin
INNciprofloxacin
Description
Ciprofloxacin is a quinolone that is quinolin-4(1H)-one bearing cyclopropyl, carboxylic acid, fluoro and piperazin-1-yl substituents at positions 1, 3, 6 and 7, respectively. It has a role as an antiinfective agent, a topoisomerase IV inhibitor, an antibacterial drug, an EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor, a DNA synthesis inhibitor, an antimicrobial agent, an environmental contaminant and a xenobiotic. It is a quinolone antibiotic, a fluoroquinolone antibiotic, a member of cyclopropanes, a N-arylpiperazine, a quinolone, an aminoquinoline and a quinolinemonocarboxylic acid. It is a conjugate base of a ciprofloxacin(1+). It is a tautomer of a ciprofloxacin zwitterion.
Classification
Small molecule
Drug classantibacterials (quinolone derivatives)
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
O=C(O)c1cn(C2CC2)c2cc(N3CCNCC3)c(F)cc2c1=O
Identifiers
PDB—
CAS-ID85721-33-1
RxCUI—
ChEMBL IDCHEMBL8
ChEBI ID100241
PubChem CID2764
DrugBankDB00537
UNII ID5E8K9I0O4U (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
₣
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Estimated US medical usage
Ciprofloxacin
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Ciprofloxacin
+
Dexamethasone
Total medical expenditures per year (USD, in millions)
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Price per prescription (USD)
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Ciprofloxacin
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Hydrocortisone
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 97,375 documents
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Safety
Black-box Warning
Black-box warning for: Ciprofloxacin, Ciprofloxacin hcl, Ciprofloxacin in dextrose, Proquin, Proquin xr
Adverse Events
Top Adverse Reactions
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60,466 adverse events reported
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