Cilostazol
Cilostazol (cilostazol) is a small molecule pharmaceutical. Cilostazol was first approved as Pletal on 1999-01-15. It is used to treat intermittent claudication, peripheral vascular diseases, and vascular graft occlusion in the USA. The pharmaceutical is active against cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B. In addition, it is known to target cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| cardiovascular diseases | D002318 |
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
Cilostazol (discontinued: Cilostazol, Pletal)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| cilostazol | ANDA | 2024-09-20 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| intermittent claudication | EFO_0003876 | D007383 | I73.9 |
| peripheral vascular diseases | EFO_0003875 | D016491 | I73.9 |
| vascular graft occlusion | — | D006083 | — |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| G9531 | Patient has documentation of ventricular shunt, brain tumor, multisystem trauma, or is currently taking an antiplatelet medication including: abciximab, anagrelide, cangrelor, cilostazol, clopidogrel, dipyridamole, eptifibatide, prasugrel, ticlopidine, ticagrelor, tirofiban, or vorapaxar |
Clinical
Clinical Trials
167 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ischemic stroke | D000083242 | — | — | — | 2 | 11 | 8 | 2 | 23 |
| Stroke | D020521 | EFO_0000712 | I63.9 | 1 | 4 | 13 | 4 | — | 21 |
| Cerebral infarction | D002544 | — | I63 | — | 2 | 7 | 10 | 1 | 20 |
| Peripheral arterial disease | D058729 | EFO_0004265 | — | 2 | 2 | 3 | 9 | 3 | 19 |
| Intermittent claudication | D007383 | EFO_0003876 | I73.9 | 6 | 3 | — | 2 | 6 | 17 |
| Peripheral vascular diseases | D016491 | EFO_0003875 | I73.9 | — | 1 | 3 | 8 | 2 | 14 |
| Coronary artery disease | D003324 | — | I25.1 | — | — | 1 | 11 | 2 | 14 |
| Ischemia | D007511 | EFO_0000556 | — | — | 3 | 5 | 5 | — | 13 |
| Infarction | D007238 | EFO_0009463 | — | — | — | 2 | 10 | 1 | 13 |
| Atherosclerosis | D050197 | EFO_0003914 | I25.1 | — | — | 1 | 7 | 2 | 10 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cerebrovascular disorders | D002561 | EFO_0003763 | I60-I69 | 1 | 1 | 1 | — | — | 3 |
| Angina pectoris | D000787 | EFO_0003913 | I20 | — | 1 | 2 | — | — | 3 |
| Variant angina pectoris | D000788 | — | I20.1 | — | 1 | 2 | — | — | 3 |
| Coronary stenosis | D023921 | EFO_1000882 | — | — | — | 2 | — | — | 2 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | 1 | 2 | — | — | 2 |
| Arthritis | D001168 | HP_0001369 | M05-M14 | — | 1 | 2 | — | — | 2 |
| Recurrence | D012008 | — | — | — | — | 1 | — | — | 1 |
| Vestibular neuronitis | D020338 | EFO_0007537 | A88.1 | — | — | 1 | — | — | 1 |
| Vestibuloplasty | D014727 | — | — | — | — | 1 | — | — | 1 |
| Diabetic foot | D017719 | EFO_1001459 | — | — | 1 | 1 | — | — | 1 |
Show 2 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cognitive dysfunction | D060825 | HP_0001268 | G31.84 | — | 2 | — | — | 1 | 3 |
| Depression | D003863 | — | F33.9 | 1 | 1 | — | — | 1 | 2 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | 1 | 1 | — | — | 1 | 2 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | 1 | 1 | — | — | 1 | 2 |
| Reperfusion | D015424 | — | — | — | 2 | — | — | — | 2 |
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | 1 | 1 | — | — | — | 1 |
| Liver diseases | D008107 | HP_0002910 | K70-K77 | 1 | 1 | — | — | — | 1 |
| Non-alcoholic fatty liver disease | D065626 | EFO_0003095 | K75.81 | 1 | 1 | — | — | — | 1 |
| Fatty liver | D005234 | EFO_0003934 | — | 1 | 1 | — | — | — | 1 |
| Leukoencephalopathies | D056784 | HP_0002352 | — | 1 | 1 | — | — | — | 1 |
Show 17 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Migraine disorders | D008881 | EFO_0003821 | G43 | 1 | — | — | — | 7 | 8 |
| Migraine with aura | D020325 | EFO_0005295 | G43.1 | 1 | — | — | — | 1 | 2 |
| Dyslipidemias | D050171 | HP_0003119 | — | 1 | — | — | — | — | 1 |
| Pain | D010146 | EFO_0003843 | R52 | 1 | — | — | — | — | 1 |
| Therapeutic equivalency | D013810 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Headache | D006261 | HP_0002315 | R51 | — | — | — | — | 7 | 7 |
| Migraine without aura | D020326 | EFO_0005296 | G43.0 | — | — | — | — | 3 | 3 |
| Bacterial infections | D001424 | — | A49 | — | — | — | — | 1 | 1 |
| Inflammation | D007249 | MP_0001845 | — | — | — | — | — | 1 | 1 |
| Tinnitus | D014012 | HP_0000360 | H93.1 | — | — | — | — | 1 | 1 |
| Dual anti-platelet therapy | D000080903 | — | — | — | — | — | — | 1 | 1 |
| Aging | D000375 | GO_0007568 | R41.81 | — | — | — | — | 1 | 1 |
| Hypersensitivity | D006967 | HP_0012393 | T78.40 | — | — | — | — | 1 | 1 |
| Post-traumatic headache | D051298 | — | G44.3 | — | — | — | — | 1 | 1 |
| Carotid stenosis | D016893 | — | — | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Cilostazol |
| INN | cilostazol |
| Description | Cilostazol is a lactam that is 3,4-dihydroquinolin-2(1H)-one in which the hydrogen at position 6 is substituted by a 4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy group. It has a role as a bronchodilator agent, a vasodilator agent, a fibrin modulating drug, a platelet aggregation inhibitor, a neuroprotective agent, an anticoagulant and an EC 3.1.4.17 (3',5'-cyclic-nucleotide phosphodiesterase) inhibitor. It is a member of tetrazoles and a lactam. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=C1CCc2cc(OCCCCc3nnnn3C3CCCCC3)ccc2N1 |
Identifiers
| PDB | — |
| CAS-ID | 73963-72-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL799 |
| ChEBI ID | 31401 |
| PubChem CID | 2754 |
| DrugBank | DB01166 |
| UNII ID | N7Z035406B (ChemIDplus, GSRS) |
Target
Agency Approved
PDE3B
PDE3B
Organism
Homo sapiens
Gene name
PDE3B
Gene synonyms
NCBI Gene ID
Protein name
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B
Protein synonyms
CGI-PDE B, CGIP1, CGIPDE1, cGMP-inhibited 3',5'-cyclic phosphodiesterase B, Cyclic GMP-inhibited phosphodiesterase B, cyclic nucleotide phosphodiesterase, phosphodiesterase 3B, cGMP-inhibited
Uniprot ID
Mouse ortholog
Pde3b (18576)
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (Q9Z1J9)
Alternate
PDE3A
PDE3A
Organism
Homo sapiens
Gene name
PDE3A
Gene synonyms
NCBI Gene ID
Protein name
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
Protein synonyms
cAMP phosphodiesterase, myocardial cGMP-inhibited, cGI-PDE, CGI-PDE A, cGMP-inhibited 3',5'-cyclic phosphodiesterase A, cGMP-inhibited cAMP phosphodiesterase, Cyclic GMP-inhibited phosphodiesterase A, phosphodiesterase 3A, cGMP-inhibited
Uniprot ID
Mouse ortholog
Pde3a (54611)
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (Q9Z0X4)
Variants
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Financial
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Estimated US medical usage
Cilostazol
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 7,095 documents
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Safety
Black-box Warning
Black-box warning for: Cilostazol
Adverse Events
Top Adverse Reactions
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4,361 adverse events reported
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