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Drug ReportsChlorhexidine
Chlorhexidine
Avagard, Bioscrub, Chg, Chloraprep, Chloraprep One-step, Chloraprep Swabstick, Chlorhexidine, Cida-stat, Exidine, Hibiclens, Hibistat, Peridex, Periogard, Prevantics, Prevantics Swabstick, Soluprep (chlorhexidine) is a small molecule pharmaceutical. Chlorhexidine was first approved as Hibiclens on 1982-01-01. It is used to treat gram-negative bacterial infections, gram-positive bacterial infections, infectious skin diseases, oral candidiasis, and periodontal diseases in the USA.
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Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
stomatognathic diseasesD009057
skin and connective tissue diseasesD017437
Trade Name
FDA
EMA
Bioscrub, Chg scrub, Chlorhexidine, Exidine, Hibiclens, Hibistat, Peridex, Periogard, Readyprep chg (discontinued: Chlorhexidine, E-z scrub, Exidine, Hibiclens, Microderm, Periochip, Periogard, Pharmaseal scrub care, Prevacare)
Combinations
Avagard, Chloraprep one-step, Chloraprep triple swabstick, Prevantics maxi swabstick, Soluprep
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Alcohol
+
Chlorhexidine gluconate
Tradename
Company
Number
Date
Products
AVAGARD3MN-021074 OTC2001-06-07
1 products, RLD, RS
Chlorhexidine gluconate
Tradename
Company
Number
Date
Products
PERIDEX3MN-019028 RX1986-08-13
1 products, RLD, RS
CHLORHEXIDINE GLUCONATEBajaj MedicalN-020111 OTC1997-09-11
1 products
CIDA-STATEcolabN-019258 OTC1986-07-22
1 products
CHG SCRUBEcolabN-019258 OTC1986-07-22
1 products
BIOSCRUBK.W. GriffenN-019822 OTC1989-03-31
1 products
READYPREP CHGMedline IndustriesN-207964 OTC2018-11-20
1 products
HIBICLENSMölnlycke Health CareN-017768 OTC1982-01-01
1 products, RLD, RS
HIBISTATMölnlycke Health CareN-018300 OTC1982-01-01
1 products, RLD, RS
CHLORHEXIDINE GLUCONATESage TherapeuticsN-021669 OTC2005-04-25
1 products, RLD, RS
EXIDINEXttrium LaboratoriesN-019125 OTC1984-12-24
1 products
Show 2 marketed
Show 5 discontinued
Chlorhexidine gluconate
+
Isopropyl alcohol
Tradename
Company
Number
Date
Products
SOLUPREP S3MN-208288 OTC2018-08-08
1 products, RLD, RS
CHLORAPREP ONE-STEPBDN-020832 OTC2000-07-14
1 products, RLD, RS
CHLORAPREP WITH TINTBDN-020832 OTC2005-05-03
1 products, RLD, RS
CHLORAPREP ONE-STEP FREPPBDN-020832 OTC2002-04-26
1 products, RLD, RS
CHLORAPREP ONE-STEPBDN-020832 OTC2003-08-20
1 products, RLD, RS
CHLORAPREP WITH TINTBDN-020832 OTC2006-04-03
1 products, RLD, RS
CHLORAPREP ONE-STEPBDN-020832 OTC2006-11-21
1 products, RLD, RS
CHLORAPREP WITH TINTBDN-020832 OTC2006-10-10
1 products, RLD, RS
CHLORAPREP ONE-STEPBDN-020832 OTC2008-10-23
1 products, RLD, RS
CHLORAPREP ONE-STEP SEPPBDN-021555 OTC2002-10-07
1 products, RLD, RS
Show 5 marketed
Labels
FDA
EMA
Brand Name
Status
Last Update
(qiqing) chlorhexidine gluconate alcohol disinfectantOTC monograph not final2020-05-15
3m avagardNew Drug Application2024-08-01
3m avagard dC2002632024-08-01
3m avagard foaming instant hand antisepticC2002632024-08-01
3m avagard foaming instant hand antisepticOTC monograph not final2011-05-19
3m soluprep sNew Drug Application2024-08-01
acclean chlorhexidine gluconate 0.12% oral rinseANDA2023-02-28
alcohol disinfectant wipesOTC monograph not final2020-06-24
anti mucedine feminine washunapproved drug other2021-04-20
anti-bacterial gelC2002632024-05-16
Show 113 more
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
periodontal diseases—D010510K05.6
infectious skin diseases—D012874—
gram-negative bacterial infections—D016905—
oral candidiasisEFO_0007406D002180B37.0
gram-positive bacterial infections—D016908—
hypercholesterolemia—D006937—
coronary artery disease—D003324I25.1
hypertriglyceridemiaEFO_0004211D015228—
hyperlipoproteinemias—D006951—
Agency Specific
FDA
EMA
Expiration
Code
CHLORHEXIDINE GLUCONATE / ISOPROPYL ALCOHOL, SOLUPREP S, 3M HEALTH CARE
2026-01-20M-292
Patent Expiration
Patent
Expires
Flag
FDA Information
Chlorhexidine Gluconate, Chlorhexidine Gluconate, Sage Prods
79350932027-10-02DPU-1022
74275742026-04-25DP
77178892025-02-27DPU-1022
70669162024-02-17U-737
Chlorhexidine Gluconate / Isopropyl Alcohol, Chloraprep One-Step, Becton Dickinson Co
74223882027-04-25DPU-1397
69913942024-01-31DP
ATC Codes
A: Alimentary tract and metabolism drugs
— A01: Stomatological preparations
— A01A: Stomatological preparations
— A01AB: Antiinfectives and antiseptics for local oral treatment
— A01AB03: Chlorhexidine
B: Blood and blood forming organ drugs
— B05: Blood substitutes and perfusion solutions
— B05C: Irrigating solutions, blood substitutes and perfusion
— B05CA: Antiinfective irrigating solutions
— B05CA02: Chlorhexidine
D: Dermatologicals
— D08: Antiseptics and disinfectants
— D08A: Antiseptics and disinfectants
— D08AC: Biguanides and amidines as antiseptics and disinfectants
— D08AC02: Chlorhexidine
— D08AC52: Chlorhexidine, combinations
— D09: Medicated dressings
— D09A: Medicated dressings
— D09AA: Medicated dressings with antiinfectives
— D09AA12: Chlorhexidine
R: Respiratory system drugs
— R02: Throat preparations
— R02A: Throat preparations
— R02AA: Antiseptic throat preparations
— R02AA05: Chlorhexidine
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01A: Antiinfective ophthalmologics
— S01AX: Other antiinfectives in atc
— S01AX09: Chlorhexidine
— S02: Otologicals
— S02A: Antiinfective drugs, otologic
— S02AA: Antiinfectives
— S02AA09: Chlorhexidine
— S03: Ophthalmological and otological preparations
— S03A: Antiinfectives, ophthalmologic and otologic
— S03AA: Antiinfectives
— S03AA04: Chlorhexidine
HCPCS
Code
Description
A4248
Chlorhexidine containing antiseptic, 1 ml
Clinical
Clinical Trials
1116 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Heart failureD006333EFO_0003144I50———1—1
InfectionsD007239EFO_0000544————1—1
Cardiac arrhythmiasD001145EFO_0004269I49.9———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients———1—1——2
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Preoperative careD011300———1———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameChlorhexidine
INNchlorhexidine
Description
Chlorhexidine is a bisbiguanide compound with a structure consisting of two (p-chlorophenyl)guanide units linked by a hexamethylene bridge. It has a role as an antiinfective agent and an antibacterial agent. It is a member of biguanides and a member of monochlorobenzenes. It is functionally related to a biguanide.
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Classification
Small molecule
Drug class—
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Structure (InChI/SMILES or Protein Sequence)
N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1
Identifiers
PDB—
CAS-ID55-56-1
RxCUI—
ChEMBL IDCHEMBL790
ChEBI ID3614
PubChem CID9552079
DrugBankDB00878
UNII IDR4KO0DY52L (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
No data
Estimated US medical usage
Chlorhexidine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 38,152 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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12,050 adverse events reported
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