Chenix, Chenodeoxycholic acid leadiant (previously known as chenodeoxycholic acid sigma-tau)(chenodiol)
Chenodiol, Ctexli (chenodiol) is a small molecule pharmaceutical. Chenodiol was first approved as Chenix on 1983-07-28. The pharmaceutical is active against bile acid receptor. In addition, it is known to target fMet-Leu-Phe receptor and G-protein coupled bile acid receptor 1.
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Trade Name
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Chenodiol, Ctexli (discontinued: Chenix)
Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Chenodiol
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| CTEXLI | Mirum Pharmaceuticals | N-219488 RX | 2025-02-21 | 1 products, RLD, RS |
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Indications
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Clinical
Clinical Trials
31 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cerebrotendinous xanthomatosis | D019294 | — | — | — | — | 1 | — | 1 | 2 |
| Xanthomatosis | D014973 | — | — | — | — | 1 | — | 1 | 2 |
Indications Phases 2
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Chenodiol |
| INN | chenodeoxycholic acid |
| Description | Chenodeoxycholic acid is a dihydroxy-5beta-cholanic acid that is (5beta)-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 7 respectively. It has a role as a human metabolite and a mouse metabolite. It is a bile acid, a dihydroxy-5beta-cholanic acid and a C24-steroid. It is a conjugate acid of a chenodeoxycholate. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@H]3[C@H](CC[C@@]21C)[C@@]1(C)CC[C@@H](O)C[C@H]1C[C@H]3O |
Identifiers
| PDB | — |
| CAS-ID | 474-25-9 |
| RxCUI | — |
| ChEMBL ID | CHEMBL240597 |
| ChEBI ID | 16755 |
| PubChem CID | 10133 |
| DrugBank | DB06777 |
| UNII ID | 0GEI24LG0J (ChemIDplus, GSRS) |
Target
Agency Approved
NR1H4
NR1H4
Organism
Homo sapiens
Gene name
NR1H4
Gene synonyms
BAR, FXR, HRR1, RIP14
NCBI Gene ID
Protein name
bile acid receptor
Protein synonyms
farnesoid X nuclear receptor, Farnesoid X-activated receptor, Farnesol receptor HRR-1, Nuclear receptor subfamily 1 group H member 4, Retinoid X receptor-interacting protein 14, RXR-interacting protein 14
Uniprot ID
Mouse ortholog
Nr1h4 (20186)
bile acid receptor (Q60641)
Variants
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Trends
PubMed Central
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Safety
Black-box Warning
Black-box warning for: Chenodal
Adverse Events
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355 adverse events reported
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