Therapeutic Area | MeSH |
---|---|
neoplasms | D009369 |
digestive system diseases | D004066 |
Brand Name | Status | Last Update |
---|---|---|
erbitux | Biologic Licensing Application | 2023-06-22 |
Indication | Ontology | MeSH | ICD-10 |
---|---|---|---|
squamous cell carcinoma | — | D002294 | — |
Expiration | Code | ||
---|---|---|---|
cetuximab, Erbitux, Eli Lilly and Company | |||
2113-03-01 | Orphan excl. |
Code | Description |
---|---|
J9055 | Injection, cetuximab, 10 mg |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Colorectal neoplasms | D015179 | — | — | 79 | 207 | 52 | 3 | 39 | 337 |
Head and neck neoplasms | D006258 | — | — | 38 | 92 | 15 | 2 | 14 | 146 |
Neoplasms | D009369 | — | C80 | 65 | 40 | 3 | 1 | 4 | 94 |
Neoplasm metastasis | D009362 | EFO_0009708 | — | 4 | 10 | 3 | 2 | — | 16 |
Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 3 | 4 | 1 | 1 | — | 8 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Squamous cell carcinoma of head and neck | D000077195 | — | — | 51 | 78 | 22 | — | 10 | 138 |
Non-small-cell lung carcinoma | D002289 | — | — | 25 | 45 | 5 | — | 1 | 63 |
Squamous cell carcinoma | D002294 | — | — | 16 | 30 | 4 | — | 5 | 42 |
Colonic neoplasms | D003110 | — | C18 | 19 | 19 | 3 | — | 5 | 41 |
Rectal neoplasms | D012004 | — | — | 14 | 24 | 1 | — | 3 | 37 |
Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 12 | 23 | 1 | — | 2 | 32 |
Squamous cell neoplasms | D018307 | — | — | 10 | 27 | 2 | — | 2 | 31 |
Esophageal neoplasms | D004938 | — | C15 | 6 | 23 | 3 | — | — | 26 |
Lung neoplasms | D008175 | HP_0100526 | C34.90 | 5 | 17 | 1 | — | 1 | 23 |
Stomach neoplasms | D013274 | EFO_0003897 | C16 | 4 | 17 | 1 | — | — | 20 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Breast neoplasms | D001943 | EFO_0003869 | C50 | 9 | 11 | — | — | — | 18 |
Verrucous carcinoma | D018289 | — | — | 7 | 5 | — | — | 1 | 11 |
Salivary gland neoplasms | D012468 | EFO_0003826 | D11 | 7 | 5 | — | — | — | 10 |
Tongue neoplasms | D014062 | EFO_0003871 | C02.9 | 6 | 4 | — | — | 1 | 10 |
Uterine cervical neoplasms | D002583 | HP_0030159 | — | 3 | 8 | — | — | — | 9 |
Glioblastoma | D005909 | EFO_0000515 | — | 6 | 5 | — | — | — | 8 |
Renal cell carcinoma | D002292 | EFO_0000376 | — | 5 | 6 | — | — | 1 | 8 |
Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 4 | 6 | — | — | — | 7 |
Cholangiocarcinoma | D018281 | — | C22.1 | — | 6 | — | — | — | 6 |
Hepatocellular carcinoma | D006528 | — | C22.0 | 2 | 3 | — | — | 1 | 5 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Melanoma | D008545 | — | — | 3 | — | — | — | 1 | 4 |
Thyroid neoplasms | D013964 | EFO_0003841 | — | 2 | — | — | — | — | 2 |
Healthy volunteers/patients | — | — | — | 2 | — | — | — | — | 2 |
Small cell carcinoma | D018288 | — | — | 1 | — | — | — | 1 | 2 |
Kidney neoplasms | D007680 | EFO_0003865 | C64 | 1 | — | — | — | — | 1 |
Digestive system neoplasms | D004067 | — | — | 1 | — | — | — | — | 1 |
Respiratory tract neoplasms | D012142 | EFO_0003853 | D14 | 1 | — | — | — | — | 1 |
Castleman disease | D005871 | EFO_1001332 | D47.Z2 | 1 | — | — | — | — | 1 |
Soft tissue neoplasms | D012983 | — | — | 1 | — | — | — | — | 1 |
Neurofibromatosis 2 | D016518 | — | Q85.02 | 1 | — | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Pain | D010146 | EFO_0003843 | R52 | — | — | — | — | 2 | 2 |
Weight loss | D015431 | HP_0001824 | — | — | — | — | — | 1 | 1 |
Prognosis | D011379 | — | — | — | — | — | — | 1 | 1 |
Lymphatic metastasis | D008207 | EFO_1001364 | — | — | — | — | — | 1 | 1 |
Deglutition disorders | D003680 | HP_0002015 | R13.1 | — | — | — | — | 1 | 1 |
Mass spectrometry | D013058 | — | — | — | — | — | — | 1 | 1 |
Drug resistance | D004351 | — | Z16.30 | — | — | — | — | 1 | 1 |
Hypersensitivity | D006967 | HP_0012393 | T78.40 | — | — | — | — | 1 | 1 |
Neuroendocrine tumors | D018358 | EFO_1001901 | D3A.8 | — | — | — | — | 1 | 1 |
Drug common name | Cetuximab |
INN | cetuximab |
Description | Immunoglobulin G 1 (human-mouse monoclonal C225 yt-chain anti-human epidermal growth factor receptor), disulfide with human-mouse monoclonal C225 x-chain, dimer |
Classification | Antibody |
Drug class | monoclonal antibodies |
Image (chem structure or protein) | ![]() |
Structure (InChI/SMILES or Protein Sequence) | >5GZ0:A,C|FM329 light chain
DIQMTQSPVILSVSPGERVSFSCRASQSIGTNIHWYQQRTNGSPRLLIKYASESISGIPSRFSGSGSGTDFTLSINSVES
EDIADYYCQQNNNWPTTFGAGTKLELKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ
ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGAEC
>5GZ0:B,D|FM329 heavy chain
QVQLKQSGPGLVQPGGSLSITCTVSGFSLTNYGVHWVRQSPGKGLEWLGVIWSGGNTDYNTPFTSRLSINKDNSKSQVFF
KMNSLQSNDTAIYYCARALTYYDYEFAYWGQGTLVTVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSW
NSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDK |
PDB | 1YY8, 1YY9, 4GW5, 4KRO, 4KRP, 5ESQ, 5ETU, 5EUK, 5F88, 5FF6, 5GZ0, 5HPM, 5HYQ, 5I2I, 5I76, 5ICX, 5ICY, 5ICZ, 5ID0, 5ID1, 5IOP, 5IR1, 5ITF, 5IV2, 5IVZ, 5T1K, 5T1L, 5T1M, 5TH2, 6ARP, 6ARU, 6AU5, 6AXP, 6AYN, 6AZK, 6AZL, 6B3S |
CAS-ID | — |
RxCUI | — |
ChEMBL ID | CHEMBL1201577 |
ChEBI ID | — |
PubChem CID | — |
DrugBank | DB00002 |
UNII ID | PQX0D8J21J (ChemIDplus, GSRS) |