Therapeutic Area | MeSH |
---|---|
neoplasms | D009369 |
digestive system diseases | D004066 |
Brand Name | Status | Last Update |
---|---|---|
erbitux | Biologic Licensing Application | 2024-07-25 |
Indication | Ontology | MeSH | ICD-10 |
---|---|---|---|
squamous cell carcinoma | — | D002294 | — |
Expiration | Code | ||
---|---|---|---|
cetuximab, Erbitux, Eli Lilly and Company | |||
2113-03-01 | Orphan excl. |
Code | Description |
---|---|
J9055 | Injection, cetuximab, 10 mg |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Colorectal neoplasms | D015179 | — | — | 8 | 13 | 4 | — | — | 23 |
Non-small-cell lung carcinoma | D002289 | — | — | 10 | 16 | 2 | — | — | 23 |
Neoplasms | D009369 | — | C80 | 8 | 10 | 1 | — | — | 17 |
Lung neoplasms | D008175 | — | C34.90 | 4 | 14 | 2 | — | — | 17 |
Adenocarcinoma | D000230 | — | — | 1 | 3 | 1 | — | — | 5 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Carcinoma | D002277 | — | C80.0 | 2 | 12 | — | — | — | 13 |
Head and neck neoplasms | D006258 | — | — | 3 | 7 | — | — | — | 9 |
Squamous cell carcinoma | D002294 | — | — | 1 | 6 | — | — | — | 6 |
Neoplasm metastasis | D009362 | EFO_0009708 | — | 2 | 3 | — | — | — | 5 |
Squamous cell carcinoma of head and neck | D000077195 | — | — | 1 | 4 | — | — | — | 4 |
Rectal neoplasms | D012004 | — | — | — | 3 | — | — | — | 3 |
Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 1 | 3 | — | — | — | 3 |
Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 1 | 2 | — | — | — | 2 |
Squamous cell neoplasms | D018307 | — | — | 1 | 2 | — | — | — | 2 |
Stomach neoplasms | D013274 | EFO_0003897 | C16 | — | 2 | — | — | — | 2 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Pancreatic ductal carcinoma | D021441 | — | — | 2 | — | — | — | — | 2 |
Melanoma | D008545 | — | — | 1 | — | — | — | — | 1 |
Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | — | — | — | — | 1 |
Drug common name | Cetuximab |
INN | cetuximab |
Description | Immunoglobulin G 1 (human-mouse monoclonal C225 yt-chain anti-human epidermal growth factor receptor), disulfide with human-mouse monoclonal C225 x-chain, dimer |
Classification | Antibody |
Drug class | monoclonal antibodies |
Image (chem structure or protein) | ![]() |
Structure (InChI/SMILES or Protein Sequence) | >5GZ0:A,C|FM329 light chain
DIQMTQSPVILSVSPGERVSFSCRASQSIGTNIHWYQQRTNGSPRLLIKYASESISGIPSRFSGSGSGTDFTLSINSVES
EDIADYYCQQNNNWPTTFGAGTKLELKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ
ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGAEC
>5GZ0:B,D|FM329 heavy chain
QVQLKQSGPGLVQPGGSLSITCTVSGFSLTNYGVHWVRQSPGKGLEWLGVIWSGGNTDYNTPFTSRLSINKDNSKSQVFF
KMNSLQSNDTAIYYCARALTYYDYEFAYWGQGTLVTVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSW
NSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDK |
PDB | 1YY8, 1YY9, 4GW5, 4KRO, 4KRP, 5ESQ, 5ETU, 5EUK, 5F88, 5FF6, 5GZ0, 5HPM, 5HYQ, 5I2I, 5I76, 5ICX, 5ICY, 5ICZ, 5ID0, 5ID1, 5IOP, 5IR1, 5ITF, 5IV2, 5IVZ, 5T1K, 5T1L, 5T1M, 5TH2, 6ARP, 6ARU, 6AU5, 6AXP, 6AYN, 6AZK, 6AZL, 6B3S |
CAS-ID | — |
RxCUI | — |
ChEMBL ID | CHEMBL1201577 |
ChEBI ID | — |
PubChem CID | — |
DrugBank | DB00002 |
UNII ID | PQX0D8J21J (ChemIDplus, GSRS) |