Erbitux(cetuximab)
Erbitux (cetuximab) is an antibody pharmaceutical. Cetuximab was first approved as Erbitux on 2004-02-12. It is used to treat squamous cell carcinoma in the USA. It has been approved in Europe to treat colorectal neoplasms and head and neck neoplasms. The pharmaceutical is active against epidermal growth factor receptor.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Mock data
Subscribe for the real data
Subscribe for the real data
Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| neoplasms | D009369 |
| digestive system diseases | D004066 |
Trade Name
FDA
EMA
Erbitux
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| erbitux | Biologic Licensing Application | 2026-04-16 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| squamous cell carcinoma | — | D002294 | — |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
cetuximab, Erbitux, Eli Lilly and Company | |||
| 2113-03-01 | Orphan excl. | ||
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J9055 | Injection, cetuximab, 10 mg |
Clinical
Clinical Trials
1228 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Colorectal neoplasms | D015179 | — | — | 134 | 290 | 68 | 5 | 50 | 477 |
| Head and neck neoplasms | D006258 | — | — | 52 | 117 | 19 | 2 | 22 | 192 |
| Neoplasms | D009369 | — | C80 | 110 | 85 | 7 | 1 | 7 | 178 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 31 | 55 | 10 | 2 | 6 | 90 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 23 | 32 | 1 | 1 | 2 | 46 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 4 | 6 | 2 | 1 | 3 | 14 |
| Exanthema | D005076 | — | — | — | 3 | 2 | 1 | 2 | 8 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Squamous cell carcinoma of head and neck | D000077195 | — | — | 71 | 127 | 43 | — | 19 | 228 |
| Non-small-cell lung carcinoma | D002289 | — | — | 61 | 72 | 6 | — | 2 | 113 |
| Colonic neoplasms | D003110 | — | C18 | 31 | 50 | 17 | — | 7 | 95 |
| Squamous cell carcinoma | D002294 | — | — | 30 | 58 | 10 | — | 14 | 94 |
| Rectal neoplasms | D012004 | — | — | 21 | 54 | 13 | — | 9 | 89 |
| Carcinoma | D002277 | — | C80.0 | 15 | 33 | 8 | — | 9 | 54 |
| Lung neoplasms | D008175 | — | C34.90 | 20 | 28 | 3 | — | 1 | 45 |
| Squamous cell neoplasms | D018307 | — | — | 12 | 31 | 3 | — | 3 | 39 |
| Recurrence | D012008 | — | — | 9 | 24 | 5 | — | — | 33 |
| Adenocarcinoma | D000230 | — | — | 9 | 21 | 5 | — | 1 | 30 |
Show 31 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 15 | 12 | — | — | 1 | 25 |
| Pancreatic ductal carcinoma | D021441 | — | — | 14 | 6 | — | — | — | 15 |
| Salivary gland neoplasms | D012468 | EFO_0003826 | D11 | 7 | 7 | — | — | — | 12 |
| Verrucous carcinoma | D018289 | — | — | 7 | 5 | — | — | 1 | 11 |
| Glioblastoma | D005909 | EFO_0000515 | — | 7 | 6 | — | — | — | 9 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 6 | 5 | — | — | — | 9 |
| Uterine cervical neoplasms | D002583 | — | — | 3 | 7 | — | — | — | 9 |
| Cholangiocarcinoma | D018281 | — | C22.1 | 2 | 6 | — | — | — | 8 |
| Sarcoma | D012509 | — | — | 4 | 4 | — | — | — | 7 |
| Melanoma | D008545 | — | — | 6 | 1 | — | — | 1 | 7 |
Show 73 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Kidney neoplasms | D007680 | EFO_0003865 | C64 | 3 | — | — | — | — | 3 |
| Gastrointestinal stromal tumors | D046152 | EFO_0000505 | C49.A | 1 | — | — | — | 1 | 2 |
| Small cell carcinoma | D018288 | — | — | 1 | — | — | — | 1 | 2 |
| Neurofibromatosis 1 | D009456 | — | Q85.01 | 1 | — | — | — | — | 1 |
| Transitional cell carcinoma | D002295 | — | — | 1 | — | — | — | — | 1 |
| Respiratory tract neoplasms | D012142 | EFO_0003853 | D14 | 1 | — | — | — | — | 1 |
| Castleman disease | D005871 | EFO_1001332 | D47.Z2 | 1 | — | — | — | — | 1 |
| Soft tissue neoplasms | D012983 | — | — | 1 | — | — | — | — | 1 |
| Neurofibromatosis 2 | D016518 | — | Q85.02 | 1 | — | — | — | — | 1 |
| Endocrine gland neoplasms | D004701 | EFO_0003769 | D35 | 1 | — | — | — | — | 1 |
Show 18 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypersensitivity | D006967 | EFO_0003785 | T78.40 | — | — | — | — | 2 | 2 |
| Pain | D010146 | EFO_0003843 | R52 | — | — | — | — | 2 | 2 |
| Chronic periodontitis | D055113 | EFO_0006343 | K05.3 | — | — | — | — | 2 | 2 |
| Periodontitis | D010518 | EFO_0000649 | K05.3 | — | — | — | — | 2 | 2 |
| Body weight | D001835 | EFO_0004338 | — | — | — | — | — | 1 | 1 |
| Weight loss | D015431 | — | — | — | — | — | — | 1 | 1 |
| Prognosis | D011379 | — | — | — | — | — | — | 1 | 1 |
| Deglutition disorders | D003680 | — | R13.1 | — | — | — | — | 1 | 1 |
| Hypoxia | D000860 | — | R09.02 | — | — | — | — | 1 | 1 |
| Mass spectrometry | D013058 | — | — | — | — | — | — | 1 | 1 |
Show 3 more
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | Cetuximab |
| INN | cetuximab |
| Description | Immunoglobulin G 1 (human-mouse monoclonal C225 yt-chain anti-human epidermal growth factor receptor), disulfide with human-mouse monoclonal C225 x-chain, dimer |
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | >5GZ0:A,C|FM329 light chain
DIQMTQSPVILSVSPGERVSFSCRASQSIGTNIHWYQQRTNGSPRLLIKYASESISGIPSRFSGSGSGTDFTLSINSVES
EDIADYYCQQNNNWPTTFGAGTKLELKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ
ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGAEC
>5GZ0:B,D|FM329 heavy chain
QVQLKQSGPGLVQPGGSLSITCTVSGFSLTNYGVHWVRQSPGKGLEWLGVIWSGGNTDYNTPFTSRLSINKDNSKSQVFF
KMNSLQSNDTAIYYCARALTYYDYEFAYWGQGTLVTVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSW
NSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDK |
Identifiers
| PDB | 1YY8, 1YY9, 4GW5, 4KRO, 4KRP, 5ESQ, 5ETU, 5EUK, 5F88, 5FF6, 5GZ0, 5HPM, 5HYQ, 5I2I, 5I76, 5ICX, 5ICY, 5ICZ, 5ID0, 5ID1, 5IOP, 5IR1, 5ITF, 5IV2, 5IVZ, 5T1K, 5T1L, 5T1M, 5TH2, 6ARP, 6ARU, 6AU5, 6AXP, 6AYN, 6AZK, 6AZL, 6B3S |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL1201577 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB00002 |
| UNII ID | PQX0D8J21J (ChemIDplus, GSRS) |
Target
Agency Approved
EGFR
EGFR
Organism
Homo sapiens
Gene name
EGFR
Gene synonyms
ERBB, ERBB1, HER1
NCBI Gene ID
Protein name
epidermal growth factor receptor
Protein synonyms
avian erythroblastic leukemia viral (v-erb-b) oncogene homolog, cell growth inhibiting protein 40, cell proliferation-inducing protein 61, EGFR vIII, epidermal growth factor receptor tyrosine kinase domain, erb-b2 receptor tyrosine kinase 1, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1
Uniprot ID
Mouse ortholog
Egfr (13649)
epidermal growth factor receptor (Q01279)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
€
£
₣
Erbitux – Eli Lilly
Mock data
Subscribe for the real data
Subscribe for the real data
Mock data
Subscribe for the real data
Subscribe for the real data
Erbitux – Bristol Myers Squibb
Mock data
Subscribe for the real data
Subscribe for the real data
Mock data
Subscribe for the real data
Subscribe for the real data
Tabular view
Estimated US medical usage
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 9,999 documents
View more details
Safety
Black-box Warning
Black-box warning for: Erbitux
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
Subscribe for the real data
36,127 adverse events reported
View more details
© 2020-2025 Collaborative Drug Discovery Inc. (CDD) | Terms of Use