Microcrystalline cellulose
Dibasic, Monobasic, Monohydrate, Phosphate (microcrystalline cellulose) is an unknown pharmaceutical. Microcrystalline cellulose was first approved as Sodium phosphates in plastic container on 1983-05-10.
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Commercial
Therapeutic Areas
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Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Cellulose sodium phosphate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| CALCIBIND | Mission Pharmacal | N-018757 DISCN | 1982-12-28 | 2 products |
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FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| liquidguard | unapproved drug other | 2020-08-09 |
| osmoprep | New Drug Application | 2010-06-04 |
| potassium phosphates | New Drug Application | 2025-02-28 |
| sodium phosphates | New Drug Application | 2024-12-09 |
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
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Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Sodium Phosphate, Dibasic, Anhydrous / Sodium Phosphate, Monobasic, Monohydrate, Osmoprep, Salix Pharms | |||
| 7687075 | 2028-06-22 | DS, DP | |
ATC Codes
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HCPCS
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Clinical
Clinical Trials
5501 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | — | 6 | 16 | 22 | 11 | 55 |
| Sclerosis | D012598 | — | — | — | 6 | 16 | 22 | 10 | 54 |
| Relapsing-remitting multiple sclerosis | D020529 | EFO_0003929 | — | — | 2 | 11 | 16 | 1 | 30 |
| Kidney transplantation | D016030 | — | — | — | 3 | 8 | 1 | — | 11 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 1 | 4 | 3 | 3 | 1 | 10 |
| Chronic progressive multiple sclerosis | D020528 | EFO_0003840 | — | — | — | 2 | 1 | 4 | 7 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | 2 | 2 | 2 | — | 6 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | — | — | 1 | 1 | 3 | 5 |
| Healthy volunteers/patients | — | — | — | 3 | — | — | 1 | — | 4 |
| Uveitis | D014605 | EFO_1001231 | H20.9 | — | 1 | — | 1 | — | 2 |
Show 14 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Leukemia | D007938 | — | C95 | 2 | 3 | 1 | — | — | 5 |
| Renal insufficiency | D051437 | — | N19 | 2 | — | 2 | — | — | 4 |
| Chronic renal insufficiency | D051436 | — | N18 | 1 | 3 | 1 | — | — | 4 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 1 | 3 | 1 | — | — | 4 |
| Carcinoma | D002277 | — | C80.0 | — | 2 | 1 | — | — | 3 |
| Hyperphosphatemia | D054559 | — | — | — | 1 | 1 | — | — | 2 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 1 | — | 1 | — | — | 2 |
| Myeloid leukemia | D007951 | — | C92 | 1 | — | 1 | — | — | 2 |
| Chronic inflammatory demyelinating polyradiculoneuropathy | D020277 | EFO_1000868 | G61.81 | — | — | 1 | — | — | 1 |
| Polyradiculoneuropathy | D011129 | EFO_1001116 | — | — | — | 1 | — | — | 1 |
Show 7 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | — | C85.9 | 1 | 3 | — | — | — | 3 |
| Lymphoid leukemia | D007945 | — | C91 | 1 | 3 | — | — | — | 3 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | — | 2 | — | — | — | 2 |
| Dermatomyositis | D003882 | EFO_0000398 | M33 | — | 2 | — | — | — | 2 |
| Polymyositis | D017285 | EFO_0003063 | M33.2 | — | 2 | — | — | — | 2 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 1 | 2 | — | — | — | 2 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 1 | 2 | — | — | — | 2 |
| Panuveitis | D015864 | EFO_1001082 | H44.11 | — | 1 | — | — | — | 1 |
| Neuritis | D009443 | — | — | — | 1 | — | — | — | 1 |
| Optic neuritis | D009902 | EFO_0007405 | H46 | — | 1 | — | — | — | 1 |
Show 29 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lung neoplasms | D008175 | — | C34.90 | 2 | — | — | — | — | 2 |
| Small cell lung carcinoma | D055752 | — | — | 2 | — | — | — | — | 2 |
| Malaria | D008288 | EFO_0001068 | B54 | 1 | — | — | — | — | 1 |
| Falciparum malaria | D016778 | EFO_0007444 | B50 | 1 | — | — | — | — | 1 |
| Liver diseases | D008107 | EFO_0001421 | K70-K77 | 1 | — | — | — | — | 1 |
| Hepatic insufficiency | D048550 | — | — | 1 | — | — | — | — | 1 |
| Myelodysplastic syndromes | D009190 | — | D46 | 1 | — | — | — | — | 1 |
| Neoplasms | D009369 | — | C80 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Disease | D004194 | EFO_0000408 | R69 | — | — | — | — | 1 | 1 |
| Disease progression | D018450 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Microcrystalline cellulose |
| INN | — |
| Description | Lacrisert (microcrystalline cellulose) is an insert placed in the eye to treat moderate to severe dry eyes. It also can be used to treat the following eye conditions: exposure keratitis, decreased corneal sensitivity and recurrent corneal erosions. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL4297557 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | — |
Target
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Variants
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Financial
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Estimated US medical usage
Microcrystalline cellulose
+
Cellulose
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Trends
PubMed Central
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Additional graphs summarizing 12,691 documents
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Safety
Black-box Warning
Black-box warning for: Osmoprep
Adverse Events
Top Adverse Reactions
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809 adverse events reported
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