Catumaxomab
Removab (catumaxomab) is an antibody pharmaceutical. Catumaxomab was first approved as Removab on 2009-04-20. It has been approved in Europe to treat ascites and neoplasms. The pharmaceutical is active against T-cell surface glycoprotein CD3 epsilon chain. In addition, it is known to target epithelial cell adhesion molecule.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| neoplasms | D009369 |
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
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Patent Expiration
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HCPCS
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Clinical
Clinical Trials
17 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | — | 2 | 1 | — | — | 3 |
| Carcinoma | D002277 | — | C80.0 | — | — | 1 | — | — | 1 |
| Neoplasms | D009369 | — | C80 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | — | 4 | — | — | — | 4 |
| Peritoneal neoplasms | D010534 | — | — | — | 3 | — | — | — | 3 |
| Adenocarcinoma | D000230 | — | — | — | 2 | — | — | — | 2 |
| Urinary bladder neoplasms | D001749 | — | C67 | 2 | 1 | — | — | — | 2 |
| Ovarian epithelial carcinoma | D000077216 | — | — | — | 2 | — | — | — | 2 |
| Fallopian tube neoplasms | D005185 | — | — | — | 1 | — | — | — | 1 |
| Ascites | D001201 | HP_0001541 | R18 | — | 1 | — | — | — | 1 |
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Catumaxomab |
| INN | catumaxomab |
| Description | Catumaxomab (rat/mouse hybrid 3funct) |
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL2108581 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB06607 |
| UNII ID | M2HPV837HO (ChemIDplus, GSRS) |
Target
Agency Approved
CD3E
CD3E
Organism
Homo sapiens
Gene name
CD3E
Gene synonyms
T3E
NCBI Gene ID
Protein name
T-cell surface glycoprotein CD3 epsilon chain
Protein synonyms
CD3-epsilon, CD3e, CD3e antigen, epsilon polypeptide (TiT3 complex), CD3e molecule, epsilon (CD3-TCR complex), T-cell antigen receptor complex, epsilon subunit of T3, T-cell surface antigen T3/Leu-4 epsilon chain
Uniprot ID
Mouse ortholog
Cd3e (12501)
T-cell surface glycoprotein CD3 epsilon chain (P22646)
Alternate
EPCAM
EPCAM
Organism
Homo sapiens
Gene name
EPCAM
Gene synonyms
GA733-2, M1S2, M4S1, MIC18, TACSTD1, TROP1
NCBI Gene ID
Protein name
epithelial cell adhesion molecule
Protein synonyms
Adenocarcinoma-associated antigen, CD326, Cell surface glycoprotein Trop-1, EGP, EGP314, Epithelial cell surface antigen, Epithelial glycoprotein, Epithelial glycoprotein 314, hEGP314, human epithelial glycoprotein-2, KS 1/4 antigen, KSA, Major gastrointestinal tumor-associated protein GA733-2, membrane component, chromosome 4, surface marker (35kD glycoprotein), trophoblast cell surface antigen 1, Tumor-associated calcium signal transducer 1
Uniprot ID
Mouse ortholog
Epcam (17075)
epithelial cell adhesion molecule (Q99JW5)
Variants
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Financial
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Trends
PubMed Central
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Safety
Black-box Warning
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Adverse Events
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