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Drug ReportsCarbamazepine
Carbamazepine
Carbamazepine, Carbatrol, Epitol, Equetro, Tegretol, Teril (carbamazepine) is a small molecule pharmaceutical. Carbamazepine was first approved as Tegretol on 1982-01-01. It is used to treat bipolar disorder, complex partial epilepsy, mood disorders, post-traumatic stress disorders, and psychotic disorders amongst others in the USA. It is known to target frizzled-8.
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Novartis Pharmaceuticals
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Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
stomatognathic diseasesD009057
nervous system diseasesD009422
chemically-induced disordersD064419
mental disordersD001523
Trade Name
FDA
EMA
Carbamazepine, Carbatrol, Epitol, Equetro, Tegretol, Teril (discontinued: Carbamazepine, Carnexiv, Tegretol, Teril)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Carbamazepine
Tradename
Company
Number
Date
Products
TEGRETOLNovartisN-016608 RX1982-01-01
1 products, RLD, RS
TEGRETOLNovartisN-018927 RX1987-12-18
1 products, RLD, RS
TEGRETOL-XRNovartisN-020234 RX1996-03-25
3 products, RLD, RS
CARBATROLTakedaN-020712 RX1997-09-30
3 products, RLD
EQUETROValidus PharmaceuticalsN-021710 RX2004-12-10
3 products, RLD, RS
Show 2 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
carbamazepin carbamazepineANDA2023-10-19
carbamazepineANDA2025-07-30
carbamazepine erANDA2024-11-13
carbatrolNew Drug Application2025-06-27
carbatrol extended-release2007-03-30
epitolANDA2024-01-31
equetroNew Drug Application2022-10-13
hand sanitizerOTC monograph not final2021-11-30
tegretolNew Drug Application2025-01-21
tegretol tegretol - xr2006-05-11
Show 1 more
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Carbamazepine, Carnexiv, Lundbeck Pharms Llc
115293572040-01-31DP
94935822033-02-27DP
76357732029-03-13DP
84100772029-03-13DP
97508222029-03-13DP
96297972028-11-10U-2004, U-2005, U-2006
97704072028-11-10DP
Carbamazepine, Equetro, Validus Pharms
69772532024-05-19U-693
ATC Codes
N: Nervous system drugs
N03: Antiepileptics
N03A: Antiepileptics
N03AF: Carboxamide derivatives, antiepileptics
N03AF01: Carbamazepine
HCPCS
No data
Clinical
Clinical Trials
165 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
EpilepsyD004827EFO_0000474G40.94312171348
Healthy volunteers/patients341136
Bipolar disorderD001714EFO_0000289F30.911310216
SeizuresD012640G40.471614
NeuralgiaD009437EFO_0009430113812
Trigeminal neuralgiaD014277EFO_1001219G50.011269
Partial epilepsiesD004828EFO_00042632518
DepressionD003863F33.912114
Cocaine-related disordersD019970F14314
Substance-related disordersD019966EFO_0003890F132114
Show 13 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
SclerosisD0125981113
Tuberous sclerosisD014402Q85.1112
SchizophreniaD012559EFO_0000692F20112
Generalized epilepsyD00482922
DementiaD003704EFO_0003862F0311
Psychophysiologic disordersD011602F45.911
Anxiety disordersD001008EFO_0006788F41.111
Somatoform disordersD013001F4511
StrokeD020521EFO_0000712I63.911
Tonic-clonic epilepsyD004830EFO_000726211
Show 2 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Central nervous system neoplasmsD016543122
Nervous system neoplasmsD009423122
Hiv infectionsD015658EFO_0000764B20112
Liver diseasesD008107EFO_0001421K70-K7711
Liver cirrhosisD008103EFO_0001422K74.011
Alpha 1-antitrypsin deficiencyD019896E88.0111
Reflex epilepsyD020195EFO_100114611
SpasmD013035M62.8311
Infantile spasmsD013036EFO_1000643G40.8211
VomitingD014839R11.111
Show 2 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
GlioblastomaD005909EFO_000051544
GliomaD005910EFO_000052044
GliosarcomaD01831644
AstrocytomaD001254EFO_000027133
Covid-19D000086382U07.133
Nervous system diseasesD009422G00-G99112
OligodendrogliomaD009837EFO_000063111
InfectionsD007239EFO_000054411
Acquired immunodeficiency syndromeD000163EFO_0000765B2011
Hepatitis bD00650911
Show 8 more
Indications Without Phase
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCarbamazepine
INNcarbamazepine
Description
Carbamazepine is a dibenzoazepine that is 5H-dibenzo[b,f]azepine carrying a carbamoyl substituent at the azepine nitrogen, used as an anticonvulsant. It has a role as an anticonvulsant, an EC 3.5.1.98 (histone deacetylase) inhibitor, a mitogen, a glutamate transporter activator, an antimanic drug, an analgesic, a non-narcotic analgesic, an environmental contaminant, a xenobiotic, a drug allergen and a sodium channel blocker. It is a dibenzoazepine and a member of ureas.
Classification
Small molecule
Drug classtricyclic compounds
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
NC(=O)N1c2ccccc2C=Cc2ccccc21
Identifiers
PDB
CAS-ID298-46-4
RxCUI
ChEMBL IDCHEMBL108
ChEBI ID3387
PubChem CID2554
DrugBankDB00564
UNII ID33CM23913M (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
FZD8
FZD8
Organism
Homo sapiens
Gene name
FZD8
Gene synonyms
NCBI Gene ID
Protein name
frizzled-8
Protein synonyms
frizzled 8, seven transmembrane spanning receptor, frizzled family receptor 8, frizzled homolog 8
Uniprot ID
Mouse ortholog
Fzd8 (14370)
frizzled-8 (Q61091)
Variants
No data
Financial
Revenue by drug
$
£
Carbatrol Shire
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Estimated US medical usage
Carbamazepine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 39,847 documents
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Safety
Black-box Warning
Black-box warning for: Carbamazepin carbamazepine, Carbamazepine, Carbamazepine er, Carbatrol, Carbatrol extended-release, Epitol, Equetro, Tegretol, Tegretol tegretol - xr
Adverse Events
Top Adverse Reactions
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48,219 adverse events reported
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