Carbamazepine
Carbamazepine, Carbatrol, Epitol, Equetro, Tegretol, Teril (carbamazepine) is a small molecule pharmaceutical. Carbamazepine was first approved as Tegretol on 1982-01-01. It is used to treat bipolar disorder, complex partial epilepsy, mood disorders, post-traumatic stress disorders, and psychotic disorders amongst others in the USA. It is known to target frizzled-8.
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Carbamazepine, Carbatrol, Epitol, Equetro, Tegretol, Teril (discontinued: Carbamazepine, Carnexiv, Tegretol, Teril)
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Abbreviated New Drug Application (ANDA)
Carbamazepine
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| TEGRETOL | Novartis | N-016608 RX | 1982-01-01 | 1 products, RLD, RS |
| TEGRETOL | Novartis | N-018927 RX | 1987-12-18 | 1 products, RLD, RS |
| TEGRETOL-XR | Novartis | N-020234 RX | 1996-03-25 | 3 products, RLD, RS |
| CARBATROL | Takeda | N-020712 RX | 1997-09-30 | 3 products, RLD |
| EQUETRO | Validus Pharmaceuticals | N-021710 RX | 2004-12-10 | 3 products, RLD, RS |
Show 2 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| carbamazepin carbamazepine | ANDA | 2023-10-19 |
| carbamazepine | ANDA | 2025-01-14 |
| carbamazepine er | ANDA | 2024-11-13 |
| carbatrol | New Drug Application | 2023-04-17 |
| carbatrol extended-release | 2007-03-30 | |
| carnexiv | New Drug Application | 2024-01-09 |
| epitol | ANDA | 2024-01-31 |
| equetro | New Drug Application | 2022-10-13 |
| hand sanitizer | OTC monograph not final | 2021-11-30 |
| tegretol | New Drug Application | 2024-07-23 |
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156 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Epilepsy | D004827 | EFO_0000474 | G40.9 | 4 | 3 | 12 | 17 | 13 | 48 |
| Healthy volunteers/patients | — | — | — | 32 | — | — | 1 | 1 | 34 |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | 1 | 1 | 3 | 10 | 2 | 16 |
| Seizures | D012640 | HP_0002069 | G40.4 | — | — | 7 | 1 | 6 | 14 |
| Partial epilepsies | D004828 | EFO_0004263 | — | — | — | 2 | 5 | 1 | 8 |
| Neuralgia | D009437 | EFO_0009430 | — | — | 1 | 1 | 2 | 5 | 8 |
| Trigeminal neuralgia | D014277 | EFO_1001219 | G50.0 | — | 1 | 1 | 1 | 3 | 5 |
| Depression | D003863 | — | F33.9 | — | 1 | 2 | 1 | 1 | 4 |
| Cocaine-related disorders | D019970 | — | F14 | — | 3 | — | 1 | — | 4 |
| Substance-related disorders | D019966 | EFO_0003890 | F13 | — | 2 | — | 1 | 1 | 4 |
Show 13 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sclerosis | D012598 | — | — | — | — | 1 | — | 1 | 2 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | 1 | — | 1 | — | — | 2 |
| Generalized epilepsy | D004829 | — | — | — | — | 2 | — | — | 2 |
| Tuberous sclerosis | D014402 | HP_0009720 | Q85.1 | — | — | 1 | — | — | 1 |
| Dementia | D003704 | EFO_0003862 | F03 | — | — | 1 | — | — | 1 |
| Psychophysiologic disorders | D011602 | — | F45.9 | — | — | 1 | — | — | 1 |
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | — | — | 1 | — | — | 1 |
| Somatoform disorders | D013001 | — | F45 | — | — | 1 | — | — | 1 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | 1 | — | — | 1 |
| Tonic-clonic epilepsy | D004830 | EFO_0007262 | — | — | — | 1 | — | — | 1 |
Show 2 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Central nervous system neoplasms | D016543 | — | — | 1 | 2 | — | — | — | 2 |
| Nervous system neoplasms | D009423 | — | — | 1 | 2 | — | — | — | 2 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 1 | 1 | — | — | — | 2 |
| Liver diseases | D008107 | HP_0002910 | K70-K77 | — | 1 | — | — | — | 1 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | 1 | — | — | — | 1 |
| Alpha 1-antitrypsin deficiency | D019896 | — | E88.01 | — | 1 | — | — | — | 1 |
| Reflex epilepsy | D020195 | EFO_1001146 | — | — | 1 | — | — | — | 1 |
| Spasm | D013035 | — | M62.83 | — | 1 | — | — | — | 1 |
| Infantile spasms | D013036 | HP_0011097 | G40.82 | — | 1 | — | — | — | 1 |
| Vomiting | D014839 | HP_0002013 | R11.1 | — | 1 | — | — | — | 1 |
Show 2 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Glioblastoma | D005909 | EFO_0000515 | — | 4 | — | — | — | — | 4 |
| Glioma | D005910 | EFO_0000520 | — | 4 | — | — | — | — | 4 |
| Gliosarcoma | D018316 | — | — | 4 | — | — | — | — | 4 |
| Astrocytoma | D001254 | EFO_0000271 | — | 3 | — | — | — | — | 3 |
| Covid-19 | D000086382 | — | — | 3 | — | — | — | — | 3 |
| Oligodendroglioma | D009837 | EFO_0000631 | — | 1 | — | — | — | — | 1 |
| Infections | D007239 | EFO_0000544 | — | 1 | — | — | — | — | 1 |
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | 1 | — | — | — | — | 1 |
| Hepatitis b | D006509 | — | — | 1 | — | — | — | — | 1 |
| High-intensity focused ultrasound ablation | D057086 | — | — | 1 | — | — | — | — | 1 |
Show 4 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Wounds and injuries | D014947 | — | T14.8 | — | — | — | — | 2 | 2 |
| Financial stress | D000086522 | — | — | — | — | — | — | 1 | 1 |
| Metabolic bone diseases | D001851 | HP_0000938 | — | — | — | — | — | 1 | 1 |
| Osteoporosis | D010024 | HP_0000939 | M81.0 | — | — | — | — | 1 | 1 |
| Pain | D010146 | EFO_0003843 | R52 | — | — | — | — | 1 | 1 |
| Hypersensitivity | D006967 | HP_0012393 | T78.40 | — | — | — | — | 1 | 1 |
| Drug hypersensitivity | D004342 | EFO_0009482 | T88.7 | — | — | — | — | 1 | 1 |
| Drug hypersensitivity syndrome | D063926 | EFO_1002004 | D72.12 | — | — | — | — | 1 | 1 |
| Premenstrual dysphoric disorder | D065446 | — | F32.81 | — | — | — | — | 1 | 1 |
| Congenital abnormalities | D000013 | EFO_0003915 | Q89.9 | — | — | — | — | 1 | 1 |
Show 20 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Carbamazepine |
| INN | carbamazepine |
| Description | Carbamazepine is a dibenzoazepine that is 5H-dibenzo[b,f]azepine carrying a carbamoyl substituent at the azepine nitrogen, used as an anticonvulsant. It has a role as an anticonvulsant, an EC 3.5.1.98 (histone deacetylase) inhibitor, a mitogen, a glutamate transporter activator, an antimanic drug, an analgesic, a non-narcotic analgesic, an environmental contaminant, a xenobiotic, a drug allergen and a sodium channel blocker. It is a dibenzoazepine and a member of ureas. |
| Classification | Small molecule |
| Drug class | tricyclic compounds |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | NC(=O)N1c2ccccc2C=Cc2ccccc21 |
Identifiers
| PDB | — |
| CAS-ID | 298-46-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL108 |
| ChEBI ID | 3387 |
| PubChem CID | 2554 |
| DrugBank | DB00564 |
| UNII ID | 33CM23913M (ChemIDplus, GSRS) |
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Carbatrol – Shire
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Carbamazepine
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Trends
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Safety
Black-box Warning
Black-box warning for: Carbamazepin carbamazepine, Carbamazepine, Carbamazepine er, Carbatrol, Carbatrol extended-release, Carnexiv, Epitol, Equetro, Tegretol, Tegretol tegretol - xr
Adverse Events
Top Adverse Reactions
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46,864 adverse events reported
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