Brand Name | Status | Last Update |
---|---|---|
ilaris | Biologic Licensing Application | 2024-11-01 |
Expiration | Code | ||
---|---|---|---|
canakinumab, Ilaris, Novartis Pharmaceuticals Corporation | |||
2027-06-16 | Orphan excl. |
Code | Description |
---|---|
J0638 | Injection, canakinumab, 1 mg |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Arthritis | D001168 | EFO_0005856 | M05-M14 | 3 | 9 | 11 | 1 | 2 | 23 |
Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | 2 | 6 | — | 1 | — | 7 |
Psoriatic arthritis | D015535 | EFO_0003778 | L40.5 | — | — | — | 1 | — | 1 |
Spondylarthritis | D025241 | — | — | — | — | — | 1 | — | 1 |
Spondylitis | D013166 | — | M46.9 | — | — | — | 1 | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Syndrome | D013577 | — | — | 2 | 6 | 9 | — | 3 | 19 |
Juvenile arthritis | D001171 | EFO_1002007 | M08 | 1 | 1 | 7 | — | 1 | 9 |
Cryopyrin-associated periodic syndromes | D056587 | — | M04.2 | — | — | 7 | — | 2 | 9 |
Gouty arthritis | D015210 | — | — | — | 2 | 5 | — | 1 | 8 |
Fever | D005334 | — | R50.9 | — | 3 | 3 | — | 1 | 7 |
Familial mediterranean fever | D010505 | — | M04.1 | — | 2 | 3 | — | 1 | 6 |
Hereditary autoinflammatory diseases | D056660 | — | — | — | 3 | 2 | — | 1 | 6 |
Non-small-cell lung carcinoma | D002289 | — | — | 1 | 2 | 3 | — | — | 6 |
Lung neoplasms | D008175 | — | C34.90 | — | 2 | 4 | — | — | 6 |
Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | 4 | 2 | — | — | 5 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Myelodysplastic syndromes | D009190 | — | D46 | 2 | 3 | — | — | — | 4 |
Preleukemia | D011289 | — | — | 2 | 3 | — | — | — | 4 |
Brucellosis | D002006 | EFO_0007185 | A23 | — | 2 | — | — | 1 | 3 |
Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | — | 2 | — | — | — | 2 |
Anemia | D000740 | EFO_0004272 | D64.9 | — | 2 | — | — | — | 2 |
Schnitzler syndrome | D019873 | EFO_1001165 | — | — | 2 | — | — | — | 2 |
Mevalonate kinase deficiency | D054078 | — | M04.1 | — | 1 | — | — | 1 | 2 |
Melanoma | D008545 | — | — | — | 1 | — | — | — | 1 |
Glucose intolerance | D018149 | HP_0000833 | R73.03 | — | 1 | — | — | — | 1 |
Knee osteoarthritis | D020370 | EFO_0004616 | M17 | — | 1 | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Breast neoplasms | D001943 | EFO_0003869 | C50 | 2 | — | — | — | — | 2 |
Triple negative breast neoplasms | D064726 | — | — | 2 | — | — | — | — | 2 |
Adenocarcinoma | D000230 | — | — | 2 | — | — | — | — | 2 |
Pancreatic ductal carcinoma | D021441 | — | — | 1 | — | — | — | — | 1 |
Renal cell carcinoma | D002292 | EFO_0000376 | — | 1 | — | — | — | — | 1 |
Carcinoma | D002277 | — | C80.0 | 1 | — | — | — | — | 1 |
Colorectal neoplasms | D015179 | — | — | 1 | — | — | — | — | 1 |
Retinal diseases | D012164 | — | H35.9 | 1 | — | — | — | — | 1 |
Diabetic retinopathy | D003930 | EFO_0003770 | — | 1 | — | — | — | — | 1 |
Macular degeneration | D008268 | EFO_0001365 | H35.30 | 1 | — | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Heart failure | D006333 | EFO_0003144 | I50 | — | — | — | — | 1 | 1 |
Systolic heart failure | D054143 | EFO_1001207 | I50.20 | — | — | — | — | 1 | 1 |
Myocardial infarction | D009203 | EFO_0000612 | I21 | — | — | — | — | 1 | 1 |
Inflammation | D007249 | MP_0001845 | — | — | — | — | — | 1 | 1 |
Infarction | D007238 | EFO_0009463 | — | — | — | — | — | 1 | 1 |
Inferior wall myocardial infarction | D056989 | EFO_1000983 | — | — | — | — | — | 1 | 1 |
Drug common name | Canakinumab |
INN | canakinumab |
Description | Immunoglobulin G1, anti-[Homo sapiens interleukin 1, beta (IL1B)] human monoclonal ACZ885; gamma1 heavy chain (Homo sapiens VH-IGHG1*03) (221-214’)-disulfide with kappa light chain (Homo sapiens V-KAPPA-IGKC*01); (227-227’’:230-230’’)-bisdisulfide dimer |
Classification | Antibody |
Drug class | monoclonal antibodies |
Image (chem structure or protein) | ![]() |
Structure (InChI/SMILES or Protein Sequence) | >4G5Z:H|canakinumab antibody fragment heavy chain
QVQLVESGGGVVQPGRSLRLSCAASGFTFSVYGMNWVRQAPAKGLEWVAIIWYDGDNQYYADSVKGRFTISRDNSKNTLY
LQMNGLRAEDTAVYYCARDLRTGPFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWN
SGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVAP
>4G5Z:L|canakinumab antibody fragment light chain
EIVLTQSPDFQSVTPKEKVTITCRASQSIGSSLHWYQQKPDQSPKLLIKYASQSFSGVPSRFSGSGSGTDFTLTINSLEA
EDAAAYYCHQSSSLPFTFGPGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ
ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRG |
PDB | 4G5Z, 4G6J, 5BVJ, 5BVP |
CAS-ID | — |
RxCUI | — |
ChEMBL ID | CHEMBL1201834 |
ChEBI ID | — |
PubChem CID | — |
DrugBank | DB06168 |
UNII ID | 37CQ2C7X93 (ChemIDplus, GSRS) |