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AboutPricing
Drug ReportsCabazitaxel
Jevtana kit, Jevtana(cabazitaxel)
Cabazitaxel, Jevtana (cabazitaxel) is a small molecule pharmaceutical. Cabazitaxel was first approved as Jevtana kit on 2010-06-17. It is used to treat prostatic neoplasms in the USA. It has been approved in Europe to treat castration-resistant prostatic neoplasms and prostatic neoplasms. The pharmaceutical is active against tubulin beta chain.
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YTD
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EMA approval date
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Study first post date
Last update post date
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Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
neoplasmsD009369
urogenital diseasesD000091642
Trade Name
FDA
EMA
Jevtana (generic drugs available since 2022-06-23)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Cabazitaxel
Tradename
Company
Number
Date
Products
CABAZITAXELACCORD HLTHCAREN-207949 RX2021-12-29
1 products, RLD, RS
JEVTANA KITSanofiN-201023 RX2010-06-17
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
jevtanaNew Drug Application2023-07-14
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
prostatic neoplasms—D011471C61
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Cabazitaxel, Jevtana Kit, Sanofi Aventis Us
89275922030-10-27U-3200
105831102030-10-27U-2753
107167772030-10-27U-2856
72419072025-12-10DP
ATC Codes
L: Antineoplastic and immunomodulating agents
— L01: Antineoplastic agents
— L01C: Plant alkaloids and other natural products, antineoplastic drugs
— L01CD: Taxanes, antineoplastic
— L01CD04: Cabazitaxel
HCPCS
Code
Description
J9043
Injection, cabazitaxel, 1 mg
Clinical
Clinical Trials
124 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Prostatic neoplasmsD011471—C611237104462
Castration-resistant prostatic neoplasmsD064129——51431323
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369—C80741—111
AdenocarcinomaD000230——151——6
Neoplasm metastasisD009362EFO_0009708——11——1
Transitional cell carcinomaD002295———11——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Breast neoplasmsD001943EFO_0003869C5015———6
Circulating neoplastic cellsD009360———2——13
Brain neoplasmsD001932EFO_0003833C7113———3
Stomach neoplasmsD013274EFO_0003897C1613———3
Non-small-cell lung carcinomaD002289———3———3
Neuroendocrine carcinomaD018278———2———2
Small cell carcinomaD018288——12———2
Ovarian neoplasmsD010051EFO_0003893C56—2———2
Urologic neoplasmsD014571—C64-C68—2———2
Squamous cell carcinoma of head and neckD000077195——11———2
Show 13 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Myeloid leukemia acuteD015470—C92.01———12
Precursor cell lymphoblastic leukemia-lymphomaD054198—C91.01———12
Myelodysplastic syndromesD009190—D461————1
Hematologic neoplasmsD019337——1————1
Pancreatic neoplasmsD010190EFO_0003860C251————1
Non-hodgkin lymphomaD008228—C85.91————1
Primary myelofibrosisD055728—D47.41————1
Multiple myelomaD009101—C90.01————1
B-cell chronic lymphocytic leukemiaD015451—C91.11————1
Bcr-abl positive chronic myelogenous leukemiaD015464EFO_0000340—1————1
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Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCabazitaxel
INNcabazitaxel
Description
Cabazitaxel is a tetracyclic diterpenoid that is 10-deacetylbaccatin III having O-methyl groups attached at positions 7 and 10 as well as an O-(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl group attached at position 13. Acts as a microtubule inhibitor, binds tubulin and promotes microtubule assembly and simultaneously inhibits disassembly. It has a role as an antineoplastic agent and a microtubule-stabilising agent. It is functionally related to a 10-deacetylbaccatin III.
Classification
Small molecule
Drug classantineoplastics, taxane derivatives
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CO[C@H]1C[C@H]2OC[C@@]2(OC(C)=O)[C@H]2[C@H](OC(=O)c3ccccc3)[C@]3(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C(C)=C([C@@H](OC)C(=O)[C@]12C)C3(C)C
Identifiers
PDB—
CAS-ID183133-96-2
RxCUI—
ChEMBL IDCHEMBL1201748
ChEBI ID63584
PubChem CID9854073
DrugBankDB06772
UNII ID51F690397J (ChemIDplus, GSRS)
Target
Agency Approved
TUBB
TUBB
Organism
Homo sapiens
Gene name
TUBB
Gene synonyms
TUBB5
NCBI Gene ID
203068
Protein name
tubulin beta chain
Protein synonyms
beta Ib tubulin, epididymis secretory sperm binding protein, tubulin beta-1 chain, Tubulin beta-5 chain, tubulin, beta polypeptide
Uniprot ID
Q9CY33
Mouse ortholog
Tubb5 (22154)
tubulin beta-5 chain (Q3UF52)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
Jevtana – Sanofi
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Estimated US medical usage
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 4,958 documents
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Safety
Black-box Warning
Black-box warning for: Jevtana
Adverse Events
Top Adverse Reactions
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2,463 adverse events reported
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