Bromelains
Bromelains is an unknown pharmaceutical. It is currently being investigated in clinical studies.
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Events Timeline
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FDA approval date
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Commercial
Therapeutic Areas
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Trade Name
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| bruselix bruising | unapproved drug other | 2024-10-11 |
| jba joint revive | unapproved drug other | 2024-08-13 |
Indications
FDA
EMA
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Agency Specific
FDA
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Patent Expiration
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ATC Codes
D: Dermatologicals
— D03: Preparations for treatment of wounds and ulcers
— D03B: Enzymes for treatment of wounds and ulcers
— D03BA: Proteolytic enzymes for treatment of wounds and ulcers
— D03BA03: Bromelains
M: Musculo-skeletal system drugs
— M09: Other drugs for disorders of the musculo-skeletal system in atc
— M09A: Other drugs for disorders of the musculo-skeletal system in atc
— M09AB: Enzymes for disorders of the musculo-skeletal system
— M09AB03: Bromelains
HCPCS
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Clinical
Clinical Trials
46 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Postoperative pain | D010149 | — | G89.18 | 1 | — | 1 | 1 | 1 | 4 |
| Covid-19 | D000086382 | — | — | 2 | 1 | — | 1 | — | 3 |
| Healthy volunteers/patients | — | — | — | — | — | — | 2 | 1 | 3 |
| Male breast neoplasms | D018567 | — | — | — | — | — | 1 | — | 1 |
| Paresthesia | D010292 | HP_0003401 | R20.2 | — | — | — | 1 | — | 1 |
| Hyperuricemia | D033461 | HP_0002149 | — | — | — | — | 1 | — | 1 |
| Cough | D003371 | HP_0012735 | R05 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Varicose ulcer | D014647 | — | — | — | 1 | 1 | — | — | 2 |
| Leg ulcer | D007871 | — | — | — | 1 | 1 | — | — | 2 |
| Thrombophlebitis | D013924 | HP_0004418 | — | — | — | 1 | — | — | 1 |
| Wounds and injuries | D014947 | — | T14.8 | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pseudomyxoma peritonei | D011553 | EFO_0007456 | — | 1 | 1 | — | — | — | 2 |
| Burns | D002056 | — | T30.0 | — | 1 | — | — | 1 | 2 |
| Respiratory distress syndrome | D012128 | EFO_1000637 | J80 | 2 | 1 | — | — | — | 2 |
| Pneumonia | D011014 | EFO_0003106 | — | 2 | 1 | — | — | — | 2 |
| Acute lung injury | D055371 | EFO_0004610 | — | 2 | 1 | — | — | — | 2 |
| Newborn respiratory distress syndrome | D012127 | — | P22 | 2 | 1 | — | — | — | 2 |
| Pulpitis | D011671 | EFO_1001139 | K04.0 | — | 1 | — | — | 1 | 2 |
| Ulcer | D014456 | MPATH_579 | — | — | 1 | — | — | 1 | 2 |
| Food-drug interactions | D018565 | — | — | — | 1 | — | — | — | 1 |
| Dental caries | D003731 | EFO_0003819 | K02 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | 1 | — | — | — | — | 1 |
| Periodontitis | D010518 | EFO_0000649 | K05.3 | 1 | — | — | — | — | 1 |
| Periodontal pocket | D010514 | EFO_1001393 | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Irritable bowel syndrome | D043183 | EFO_0000555 | K58 | — | — | — | — | 2 | 2 |
| Inflammation | D007249 | MP_0001845 | — | — | — | — | — | 1 | 1 |
| Wound healing | D014945 | GO_0042060 | — | — | — | — | — | 1 | 1 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | — | — | — | — | 1 | 1 |
| Plantar fasciitis | D036981 | EFO_1001909 | M72.2 | — | — | — | — | 1 | 1 |
| Fasciitis | D005208 | HP_0100537 | M72.9 | — | — | — | — | 1 | 1 |
| Retinal diseases | D012164 | HP_0000479 | H35.9 | — | — | — | — | 1 | 1 |
| Diabetic retinopathy | D003930 | EFO_0003770 | — | — | — | — | — | 1 | 1 |
| Edema | D004487 | HP_0000969 | R60.9 | — | — | — | — | 1 | 1 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | — | — | — | 1 | 1 |
Show 18 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Bromelains |
| INN | bromelains |
| Description | Bromelain is an enzyme extract derived from the stems of pineapples, although it exists in all parts of the fresh plant and fruit. The extract has a history of folk medicine use. As a culinary ingredient, it may be used as a meat tenderizer.
|
| Classification | Unknown |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL2109027 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | U182GP2CF3 (ChemIDplus, GSRS) |
Target
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Variants
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Financial
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Trends
PubMed Central
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Additional graphs summarizing 4,361 documents
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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72 adverse events reported
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