Beovu(brolucizumab)
Beovu (brolucizumab) is an antibody pharmaceutical. Brolucizumab was first approved as Beovu on 2019-10-07. It is used to treat wet macular degeneration in the USA. It has been approved in Europe to treat wet macular degeneration. The pharmaceutical is active against vascular endothelial growth factor A, long form. In addition, it is known to target Vascular permeability factor.
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FDA approval date
EMA approval date
Patent expiration date
Study first post date
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Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| eye diseases | D005128 |
Trade Name
FDA
EMA
Beovu
Drug Products
FDA
EMA
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| beovu | Biologic Licensing Application | 2025-02-24 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| wet macular degeneration | EFO_0004683 | D057135 | — |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J0179 | Injection, brolucizumab-dbll, 1 mg |
Clinical
Clinical Trials
61 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Macular degeneration | D008268 | EFO_0001365 | H35.30 | — | — | 11 | 4 | 17 | 32 |
| Wet macular degeneration | D057135 | EFO_0004683 | — | — | — | 8 | 4 | 6 | 18 |
| Vision disorders | D014786 | — | H53.11 | — | — | 7 | 1 | 1 | 9 |
| Retinal diseases | D012164 | — | H35.9 | — | — | 1 | 1 | — | 2 |
| Retinal degeneration | D012162 | — | — | — | — | 1 | 1 | — | 2 |
| Eye diseases | D005128 | EFO_0003966 | H44 | — | — | 1 | 1 | — | 2 |
| Choroidal neovascularization | D020256 | — | — | — | — | — | 1 | 1 | 2 |
| Geographic atrophy | D057092 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Macular edema | D008269 | — | — | — | — | 7 | — | 3 | 10 |
| Edema | D004487 | — | R60.9 | — | — | 5 | — | 2 | 7 |
| Low vision | D015354 | — | — | — | — | 5 | — | 1 | 6 |
| Retinal vein occlusion | D012170 | EFO_1001157 | H34.81 | — | — | 2 | — | — | 2 |
| Diabetic retinopathy | D003930 | EFO_0003770 | — | — | — | 1 | — | — | 1 |
| Retinal neovascularization | D015861 | — | H35.05 | — | — | 1 | — | — | 1 |
| Vascular diseases | D014652 | EFO_0004264 | I77 | — | — | 1 | — | — | 1 |
| Polypoidal choroidal vasculopathy | D000092342 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Uveitis | D014605 | EFO_1001231 | H20.9 | — | — | — | — | 1 | 1 |
| Inflammation | D007249 | MP_0001845 | — | — | — | — | — | 1 | 1 |
| Retinal artery occlusion | D015356 | EFO_1001154 | H34.1 | — | — | — | — | 1 | 1 |
| Vasculitis | D014657 | EFO_0006803 | M31 | — | — | — | — | 1 | 1 |
| Retinal vasculitis | D031300 | EFO_1001156 | H35.06 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Brolucizumab |
| INN | brolucizumab |
| Description | Brolucizumab sold under trade name Beovu among others, is a humanized single-chain antibody fragment for the treatment of neovascular (wet) age-related macular degeneration (AMD).
|
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL3707357 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB14864 |
| UNII ID | XSZ53G39H5 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
VEGFA
VEGFA
Organism
Homo sapiens
Gene name
VEGFA
Gene synonyms
NCBI Gene ID
—
Protein name
Vascular endothelial growth factor A
Protein synonyms
Vascular permeability factor
Uniprot ID
Mouse ortholog
—
—
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
Beovu – Novartis
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Tabular view
Estimated US medical usage
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,388 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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3,612 adverse events reported
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