Bimagrumab
Bimagrumab is an antibody pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against activin receptor type-2B. In addition, it is known to target activin receptor type-2A.
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Commercial
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Clinical
Clinical Trials
17 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myositis | D009220 | EFO_0000783 | G72.49 | — | 3 | 3 | — | — | 4 |
| Inclusion body myositis | D018979 | EFO_0007323 | G72.41 | — | 3 | 3 | — | — | 4 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Overweight | D050177 | — | E66.3 | — | 4 | — | — | — | 4 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | 4 | — | — | — | 4 |
| Wasting syndrome | D019282 | — | — | — | 3 | — | — | — | 3 |
| Cachexia | D002100 | — | R64 | — | 3 | — | — | — | 3 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | 2 | — | — | — | 2 |
| Sarcopenia | D055948 | EFO_1000653 | M62.84 | — | 2 | — | — | — | 2 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | 1 | — | — | — | 1 |
| Hip fractures | D006620 | EFO_0003964 | S72.00 | — | 1 | — | — | — | 1 |
| Bone fractures | D050723 | EFO_0003931 | T14.8 | — | 1 | — | — | — | 1 |
| Muscular atrophy | D009133 | — | — | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Bimagrumab |
| INN | bimagrumab |
| Description | Bimagrumab (human mab) |
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | >5NHW:H|anti-human ActRII Bimagrumab Fab heavy-chain
(PCA)VQLVQSGAEVKKPGASVKVSCKASGYTFTSSYINWVRQAPGQGLEWMGTINPVSGSTSYAQKFQGRVTMTRDTSI
STAYMELSRLRSDDTAVYYCARGGWFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSW
NSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSEFDYKDDDDKGAPHHHHHH
>5NHW:L|anti-human ActRII Bimagrumab Fab light-chain
QSALTQPASVSGSPGQSITISCTGTSSDVGSYNYVNWYQQHPGKAPKLMIYGVSKRPSGVSNRFSGSKSGNTASLTISGL
QAEDEADYYCGTFAGGSYYGVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPV
KAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTEA |
Identifiers
| PDB | 5NGV, 5NH3, 5NHR, 5NHW |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL3137353 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | N15SW1DIV8 (ChemIDplus, GSRS) |
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Adverse Events
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