Bethanechol
Bethanechol, Duvoid (bethanechol) is a small molecule pharmaceutical. Bethanechol was first approved as Urecholine on 1982-01-01. It is used to treat drug-induced abnormalities, gastroesophageal reflux, neurogenic urinary bladder, and urinary retention in the USA. The pharmaceutical is active against muscarinic acetylcholine receptor M2 and muscarinic acetylcholine receptor M3. In addition, it is known to target muscarinic acetylcholine receptor M5, muscarinic acetylcholine receptor M1, and muscarinic acetylcholine receptor M4.
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Commercial
Trade Name
FDA
EMA
Bethanechol, Duvoid (discontinued: Bethanechol, Myotonachol, Urecholine)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Bethanechol chloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| URECHOLINE | Odyssey Pharmaceuticals | N-006536 DISCN | 1982-01-01 | 5 products, RLD |
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FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| bethanechol chloride | ANDA | 2024-10-23 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J0520 | Injection, bethanechol chloride, myotonachol or urecholine, up to 5 mg |
Clinical
Clinical Trials
7 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 1 | 1 | — | — | — | 2 |
| Eosinophilic esophagitis | D057765 | EFO_0004232 | K20.0 | — | 1 | — | — | — | 1 |
| Esophagitis | D004941 | HP_0100633 | K20 | — | 1 | — | — | — | 1 |
| Adenocarcinoma | D000230 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 1 | — | — | — | — | 1 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | 1 | — | — | — | — | 1 |
| Esophageal motility disorders | D015154 | — | K22.4 | 1 | — | — | — | — | 1 |
| Diffuse esophageal spasm | D015155 | EFO_1001785 | K22.4 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Tracheobronchomalacia | D055089 | — | — | — | — | — | — | 1 | 1 |
| Bronchomalacia | D055091 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Bethanechol |
| INN | — |
| Description | Bethanechol is the carbamic acid ester of 2-methylcholine. A slowly hydrolysed muscarinic agonist with no nicotinic effects, it is used as its chloride salt to increase smooth muscle tone, as in the gastrointestinal tract following abdominal surgery, treatment of gastro-oesophageal reflux disease, and as an alternative to catheterisation in the treatment of non-obstructive urinary retention. It has a role as a muscarinic agonist. It is a quaternary ammonium ion and a carbamate ester. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(C[N+](C)(C)C)OC(N)=O |
Identifiers
| PDB | — |
| CAS-ID | 674-38-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1482 |
| ChEBI ID | 3084 |
| PubChem CID | 2370 |
| DrugBank | DB01019 |
| UNII ID | — |
Target
Agency Approved
CHRM2
CHRM2
CHRM3
CHRM3
Variants
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Estimated US medical usage
Bethanechol
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
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Additional graphs summarizing 1,913 documents
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Safety
Black-box Warning
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Adverse Events
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209 adverse events reported
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