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Drug ReportsAtropine
Atropine
Atropen, Atropine, Duodote, Enlon, Lomotil, Motofen (atropine) is a small molecule pharmaceutical. Atropine was first approved as Atropen on 1982-01-01. It is used to treat bradycardia, heart arrest, poisoning, sinoatrial block, and stomach ulcer amongst others in the USA. The pharmaceutical is active against muscarinic acetylcholine receptor M3, muscarinic acetylcholine receptor M2, muscarinic acetylcholine receptor M1, muscarinic acetylcholine receptor M5, and muscarinic acetylcholine receptor M4. In addition, it is known to target alpha-2A adrenergic receptor.
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Clinical
Drug
Target
Variants
Financial
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Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
digestive system diseasesD004066
eye diseasesD005128
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
chemically-induced disordersD064419
Trade Name
FDA
EMA
Atropine, Isopto atropine (discontinued: Atropen, Atropine)
Combinations
Diphenoxylate atropine, Duodote, Lomotil, Motofen (discontinued: Atnaa, Atropine demerol, Colonaid, Diphenoxylate atropine, Diphenoxylate w/ atropine, Enlon, Logen, Lomanate, Lomotil, Lonox, Low-quel, Meperidine atropine, Motofen)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Atropine sulfate
+
Edrophonium chloride
Tradename
Company
Number
Date
Products
ENLON-PLUSMylanN-019678 DISCN1991-11-06
1 products, RLD
ENLON-PLUSMylanN-019677 DISCN1991-11-06
1 products
Hide discontinued
Atropine sulfate
Tradename
Company
Number
Date
Products
ATROPINE SULFATEAccord HealthcareN-214652 RX2020-09-29
2 products, RLD, RS
ISOPTO ATROPINEAlcon ResearchN-208151 RX2016-12-01
1 products, RLD, RS
ATROPINE SULFATEBausch Health CompaniesN-213581 RX2022-03-15
1 products, RLD, RS
ATROPINE SULFATEFresenius KabiN-209260 RX2018-01-26
1 products, RLD, RS
ATROPINE SULFATEHospiraN-021146 RX2001-07-09
3 products, RLD, RS
ATROPINE SULFATERising PharmaceuticalsN-206289 RX2014-07-18
1 products, RLD
Show 1 discontinued
Atropine sulfate
+
Diphenoxylate hydrochloride
Tradename
Company
Number
Date
Products
LOMOTILPfizerN-012462 RX1982-01-01
1 products, RLD, RS
Show 1 discontinued
Atropine sulfate
+
Difenoxin hydrochloride
Tradename
Company
Number
Date
Products
MOTOFENSebela PharmaceuticalsN-017744 RX1982-01-01
1 products, RLD, RS
Show 1 discontinued
Atropine
Tradename
Company
Number
Date
Products
ATROPENMeridian Medical TechnologiesN-017106 DISCN1982-01-01
4 products, RLD
ATROPINE (AUTOINJECTOR)Rafa LaboratoriesN-212319 DISCN2018-07-09
1 products
Hide discontinued
Atropine
+
Pralidoxime chloride
Tradename
Company
Number
Date
Products
DUODOTEMeridian Medical TechnologiesN-021983 RX2006-09-28
1 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
atnaa2007-05-17
atnaa atropine and pralidoxime chlorideNew Drug Application2022-07-18
atropen auto-injectorNew Drug Application2022-09-15
atropineANDA2025-09-29
atropine careunapproved drug other2011-01-06
atropine sulfateNew Drug Application2025-09-29
cold and flu reliefunapproved drug other2021-01-13
diphenoxylate hcl and atropine sulfateANDA2010-03-24
diphenoxylate hydrochloride and atropine sulfateANDA2025-08-05
direct rxNDA authorized generic2015-08-05
Show 12 more
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
uveitisEFO_1001231D014605H20.9
diarrhea—D003967R19.7
stomach ulcer—D013276K25
bradycardia—D001919R00.1
heart arrestEFO_0009492D006323I46
poisoningEFO_0008546D011041T65.91
sinoatrial block—D012848I45.5
drug-induced abnormalities—D000014—
painEFO_0003843D010146R52
drug overdose—D062787—
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
— A03: Drugs for functional gastrointestinal disorders
— A03B: Belladonna and derivatives containing drugs, plain for functional gastrointestinal disorders
— A03BA: Belladonna alkaloids, tertiary amines for functional gastrointestinal disorders
— A03BA01: Atropine
— A03C: Antispasmodics in combination with psycholeptics
— A03CB: Belladonna and derivatives in combination with psycholeptics
— A03CB03: Atropine and psycholeptics
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01F: Mydriatics and cycloplegics
— S01FA: Anticholinergic mydriatics and cycloplegics
— S01FA01: Atropine
HCPCS
Code
Description
J0461
Injection, atropine sulfate, 0.01 mg
J7635
Atropine, inhalation solution, compounded product, administered through dme, concentrated form, per milligram
J7636
Atropine, inhalation solution, compounded product, administered through dme, unit dose form, per milligram
Clinical
Clinical Trials
470 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Chronic obstructive pulmonary diseaseD029424EFO_0000341J44.9—2———2
Respiratory insufficiencyD012131—J96.9—1———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameAtropine
INNedrophonium chloride
Description
Atropine is a racemate composed of equimolar concentrations of (S)- and (R)-atropine. It is obtained from deadly nightshade (Atropa belladonna) and other plants of the family Solanaceae. It has a role as a muscarinic antagonist, an anaesthesia adjuvant, an anti-arrhythmia drug, a mydriatic agent, a parasympatholytic, a bronchodilator agent, a plant metabolite, an antidote to sarin poisoning and a oneirogen. It contains a (S)-atropine and a (R)-atropine.
Classification
Small molecule
Drug classatropine derivatives
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CN1[C@H]2CC[C@@H]1C[C@H](OC(=O)C(CO)c1ccccc1)C2
Identifiers
PDB—
CAS-ID51-55-8
RxCUI—
ChEMBL IDCHEMBL517712
ChEBI ID16684
PubChem CID174174
DrugBankDB00572
UNII IDQO611KSM5P (ChemIDplus, GSRS)
Target
Agency Approved
CHRM3
CHRM3
CHRM2
CHRM2
CHRM1
CHRM1
CHRM5
CHRM5
CHRM4
CHRM4
Organism
Homo sapiens
Gene name
CHRM3
Gene synonyms
NCBI Gene ID
1131
Protein name
muscarinic acetylcholine receptor M3
Protein synonyms
acetylcholine receptor, muscarinic 3, m3 muscarinic receptor
Uniprot ID
Q9HB60
Mouse ortholog
Chrm3 (12671)
muscarinic acetylcholine receptor M3 (Q9ERZ3)
Alternate
ADRA2A
ADRA2A
Organism
Homo sapiens
Gene name
ADRA2A
Gene synonyms
ADRA2R, ADRAR
NCBI Gene ID
150
Protein name
alpha-2A adrenergic receptor
Protein synonyms
adrenergic, alpha-2A-, receptor, Alpha-2 adrenergic receptor subtype C10, alpha-2-adrenergic receptor, platelet type, Alpha-2A adrenoceptor, Alpha-2A adrenoreceptor, Alpha-2AAR, alpha-2AAR subtype C10
Uniprot ID
Q9BZK1
Mouse ortholog
Adra2a (11551)
alpha-2A adrenergic receptor (Q3URE6)
Variants
No data
Financial
Revenue by drug
$
€
£
₣
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Estimated US medical usage
Atropine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Atropine
+
Difenoxin
Total medical expenditures per year (USD, in millions)
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Atropine
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Diphenoxylate
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 64,323 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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6,626 adverse events reported
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