Agrylin, Xagrid(anagrelide)
Agrylin, Anagrelide, Xagrid (anagrelide) is a small molecule pharmaceutical. Anagrelide was first approved as Agrylin on 1997-03-14. It is used to treat polycythemia vera and thrombocytosis in the USA. It has been approved in Europe to treat essential thrombocythemia. The pharmaceutical is active against cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A.
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FDA approval date
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| neoplasms | D009369 |
| hemic and lymphatic diseases | D006425 |
Trade Name
FDA
EMA
Agrylin, Anagrelide (discontinued: Agrylin, Anagrelide)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| agrylin | New Drug Application | 2024-12-24 |
| anagrelide | ANDA | 2024-10-02 |
| anagrelide hydrochloride | ANDA | 2022-05-04 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| polycythemia vera | — | D011087 | D45 |
| thrombocytosis | — | D013922 | D75.83 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| G9531 | Patient has documentation of ventricular shunt, brain tumor, multisystem trauma, or is currently taking an antiplatelet medication including: abciximab, anagrelide, cangrelor, cilostazol, clopidogrel, dipyridamole, eptifibatide, prasugrel, ticlopidine, ticagrelor, tirofiban, or vorapaxar |
Clinical
No data
Drug
General
| Drug common name | Anagrelide |
| INN | anagrelide |
| Description | Anagrelide (Agrylin/Xagrid, Shire and Thromboreductin, AOP Orphan Pharmaceuticals AG) is a drug used for the treatment of essential thrombocytosis (also known as essential thrombocythemia), or overproduction of blood platelets. It also has been used in the treatment of chronic myeloid leukemia.
|
| Classification | Small molecule |
| Drug class | platelet aggregation inhibitors, primarily platelet P2Y12 receptor antagonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=C1CN2Cc3c(ccc(Cl)c3Cl)N=C2N1 |
Identifiers
| PDB | — |
| CAS-ID | 68475-42-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL760 |
| ChEBI ID | 142290 |
| PubChem CID | 2182 |
| DrugBank | DB00261 |
| UNII ID | K9X45X0051 (ChemIDplus, GSRS) |
Target
Agency Approved
PDE3A
PDE3A
Organism
Homo sapiens
Gene name
PDE3A
Gene synonyms
NCBI Gene ID
Protein name
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
Protein synonyms
cAMP phosphodiesterase, myocardial cGMP-inhibited, cGI-PDE, CGI-PDE A, cGMP-inhibited 3',5'-cyclic phosphodiesterase A, cGMP-inhibited cAMP phosphodiesterase, Cyclic GMP-inhibited phosphodiesterase A, phosphodiesterase 3A, cGMP-inhibited
Uniprot ID
Mouse ortholog
Pde3a (54611)
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (Q9Z0X4)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
€
£
₣
Xagrid – Shire
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Estimated US medical usage
Anagrelide
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Trends
No data
Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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