Afimoxifene
Afimoxifene is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target estrogen receptor, estrogen receptor beta, estrogen-related receptor gamma, and G-protein coupled estrogen receptor 1.
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FDA approval date
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Study first post date
Last update post date
Start date
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Commercial
No data
Clinical
Clinical Trials
19 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypertension | D006973 | EFO_0000537 | I10 | 2 | 2 | 1 | — | — | 4 |
| Ocular hypertension | D009798 | EFO_1001069 | H40.0 | 2 | 2 | 1 | — | — | 4 |
| Glaucoma | D005901 | EFO_0000516 | H40 | 2 | 2 | 1 | — | — | 4 |
| Open-angle glaucoma | D005902 | EFO_0004190 | H40.1 | 2 | 2 | 1 | — | — | 4 |
| Breast density | D000071060 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 6 | — | — | 1 | 7 |
| Carcinoma | D002277 | — | C80.0 | — | 4 | — | — | — | 4 |
| Carcinoma in situ | D002278 | — | D09.9 | — | 4 | — | — | — | 4 |
| Breast carcinoma in situ | D000071960 | — | D05 | — | 4 | — | — | — | 4 |
| Ductal carcinoma breast | D018270 | — | — | — | 3 | — | — | — | 3 |
| Intraductal carcinoma noninfiltrating | D002285 | — | D05.1 | — | 3 | — | — | — | 3 |
| Neoplasms | D009369 | — | C80 | — | 2 | — | — | — | 2 |
| Adenocarcinoma | D000230 | — | — | — | 1 | — | — | — | 1 |
| Lobular carcinoma | D018275 | EFO_0000570 | — | — | 1 | — | — | — | 1 |
| Hyperplasia | D006965 | EFO_0000536 | — | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Inflammation | D007249 | MP_0001845 | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Dental caries | D003731 | EFO_0003819 | K02 | — | — | — | — | 1 | 1 |
| Feeding behavior | D005247 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Afimoxifene |
| INN | afimoxifene |
| Description | Afimoxifene is a tertiary amino compound that is tamoxifen in which the phenyl group which is in a Z- relationship to the ethyl substituent is hydroxylated at the para- position. It is the active metabolite of tamoxifen. It has a role as an antineoplastic agent, an estrogen receptor antagonist and a metabolite. It is a tertiary amino compound and a member of phenols. It is functionally related to a tamoxifen. |
| Classification | Small molecule |
| Drug class | antiestrogens of the clomifene and tamoxifen groups |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC/C(=C(\c1ccc(O)cc1)c1ccc(OCCN(C)C)cc1)c1ccccc1 |
Identifiers
| PDB | — |
| CAS-ID | 68392-35-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL489 |
| ChEBI ID | 44616 |
| PubChem CID | 449459 |
| DrugBank | — |
| UNII ID | 17197F0KYM (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
ESR1
ESR1
ESR2
ESR2
ESRRG
ESRRG
GPER1
GPER1
Organism
Homo sapiens
Gene name
ESR1
Gene synonyms
ESR, NR3A1
NCBI Gene ID
Protein name
estrogen receptor
Protein synonyms
E2 receptor alpha, ER-alpha, Estradiol receptor, estrogen nuclear receptor alpha, estrogen receptor alpha E1-E2-1-2, estrogen receptor alpha E1-N2-E2-1-2, Nuclear receptor subfamily 3 group A member 1, oestrogen receptor alpha
Uniprot ID
Mouse ortholog
Esr1 (13982)
estrogen receptor (Q9QY52)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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