Therapeutic Area | MeSH |
---|---|
neoplasms | D009369 |
respiratory tract diseases | D012140 |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
GILOTRIF | Boehringer Ingelheim | N-201292 RX | 2013-07-12 | 3 products, RLD, RS |
Brand Name | Status | Last Update |
---|---|---|
gilotrif | New Drug Application | 2022-07-11 |
Indication | Ontology | MeSH | ICD-10 |
---|---|---|---|
non-small-cell lung carcinoma | — | D002289 | — |
squamous cell carcinoma | — | D002294 | — |
Expiration | Code | ||
---|---|---|---|
AFATINIB DIMALEATE, GILOTRIF, BOEHRINGER INGELHEIM | |||
2025-10-07 | PED | ||
2025-07-12 | PED | ||
2025-04-07 | M-276 | ||
2025-01-12 | ODE-230 | ||
2023-10-15 | PED | ||
2023-04-15 | ODE-115 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Non-small-cell lung carcinoma | D002289 | — | — | 16 | 32 | 11 | 5 | 26 | 86 |
Squamous cell neoplasms | D018307 | — | — | 2 | 4 | 1 | 1 | — | 8 |
Neoplasm metastasis | D009362 | EFO_0009708 | — | — | 1 | — | 1 | — | 2 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Breast neoplasms | D001943 | EFO_0003869 | C50 | 4 | 12 | 1 | — | — | 16 |
Squamous cell carcinoma of head and neck | D000077195 | — | — | 4 | 7 | 1 | — | — | 11 |
Head and neck neoplasms | D006258 | — | — | 1 | 5 | 4 | — | — | 10 |
Adenocarcinoma | D000230 | — | — | — | — | 2 | — | — | 2 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Neoplasms | D009369 | — | C80 | 19 | 9 | — | — | 3 | 29 |
Lung neoplasms | D008175 | HP_0100526 | C34.90 | 2 | 10 | — | — | — | 11 |
Stomach neoplasms | D013274 | EFO_0003897 | C16 | 1 | 5 | — | — | — | 6 |
Squamous cell carcinoma | D002294 | — | — | 1 | 5 | — | — | — | 6 |
Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 4 | 2 | — | — | — | 5 |
Colorectal neoplasms | D015179 | — | — | 1 | 5 | — | — | — | 5 |
Esophageal squamous cell carcinoma | D000077277 | — | — | 2 | 3 | — | — | — | 5 |
Prostatic neoplasms | D011471 | — | C61 | 1 | 2 | — | — | — | 3 |
Multiple myeloma | D009101 | — | C90.0 | 1 | 2 | — | — | — | 3 |
Esophageal neoplasms | D004938 | — | C15 | — | 3 | — | — | — | 3 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Healthy volunteers/patients | — | — | — | 7 | — | — | — | — | 7 |
Myeloid leukemia acute | D015470 | — | C92.0 | 1 | — | — | — | 1 | 2 |
Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 1 | — | — | — | 1 | 2 |
Glioblastoma | D005909 | EFO_0000515 | — | 2 | — | — | — | — | 2 |
Syndrome | D013577 | — | — | 2 | — | — | — | — | 2 |
Myelodysplastic syndromes | D009190 | — | D46 | 1 | — | — | — | — | 1 |
Hematologic neoplasms | D019337 | — | — | 1 | — | — | — | — | 1 |
Non-hodgkin lymphoma | D008228 | — | C85.9 | 1 | — | — | — | — | 1 |
Primary myelofibrosis | D055728 | — | D47.4 | 1 | — | — | — | — | 1 |
B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 1 | — | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Multiple primary neoplasms | D009378 | — | — | — | — | — | — | 1 | 1 |
Paronychia | D010304 | EFO_0007421 | L03.0 | — | — | — | — | 1 | 1 |
Drug common name | Afatinib |
INN | afatinib |
Description | Afatinib is a quinazoline compound having a 3-chloro-4-fluoroanilino group at the 4-position, a 4-dimethylamino-trans-but-2-enamido group at the 6-position, and an (S)-tetrahydrofuran-3-yloxy group at the 7-position. Used (as its dimaleate salt) for the first-line treatment of patients with metastatic non-small cell lung cancer. It has a role as a tyrosine kinase inhibitor and an antineoplastic agent. It is a member of quinazolines, a member of furans, an organofluorine compound, an enamide, an aromatic ether, a tertiary amino compound, a member of monochlorobenzenes and a secondary carboxamide. |
Classification | Small molecule |
Drug class | tyrosine kinase inhibitors |
Image (chem structure or protein) | |
Structure (InChI/SMILES or Protein Sequence) | CN(C)C/C=C/C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1 |
PDB | — |
CAS-ID | 850140-72-6 |
RxCUI | — |
ChEMBL ID | CHEMBL1173655 |
ChEBI ID | 61390 |
PubChem CID | 10184653 |
DrugBank | DB08916 |
UNII ID | 41UD74L59M (ChemIDplus, GSRS) |