Ademetionine
Ademetionine is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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47 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Liver diseases | D008107 | HP_0002910 | K70-K77 | — | 1 | 3 | 1 | 1 | 6 |
| Hepatitis | D006505 | HP_0012115 | K75.9 | — | 3 | 2 | 2 | — | 6 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | 1 | 2 | — | 1 | 2 | 6 |
| Alcoholic liver diseases | D008108 | EFO_0008573 | K70 | — | 1 | 2 | 1 | 1 | 5 |
| Liver failure | D017093 | HP_0001399 | K72.9 | 1 | 2 | — | 1 | 1 | 4 |
| Hepatic insufficiency | D048550 | — | — | 1 | 2 | — | 1 | 1 | 4 |
| Hepatitis a | D006506 | EFO_0007305 | B15 | — | 2 | 1 | 2 | — | 4 |
| Hepatitis b | D006509 | — | — | — | — | — | 2 | 1 | 3 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | 1 | 1 | — | 1 | — | 3 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | 2 | — | 1 | — | 3 |
Show 8 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hepatitis c | D006526 | — | B19.2 | — | 3 | 1 | — | — | 3 |
| Non-alcoholic fatty liver disease | D065626 | EFO_0003095 | K75.81 | — | — | 2 | — | 1 | 3 |
| Fatty liver | D005234 | EFO_0003934 | — | — | — | 2 | — | 1 | 3 |
| Chronic hepatitis c | D019698 | EFO_0004220 | B18.2 | — | 2 | 1 | — | — | 2 |
| Prostatic neoplasms | D011471 | — | C61 | — | — | 1 | — | — | 1 |
| Adenocarcinoma | D000230 | — | — | — | — | 1 | — | — | 1 |
| Intrahepatic cholestasis | D002780 | — | — | — | — | 1 | — | — | 1 |
| Tobacco use disorder | D014029 | — | F17 | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Depression | D003863 | — | F33.9 | — | 2 | — | — | 3 | 5 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 1 | 2 | — | — | 1 | 4 |
| Cognitive dysfunction | D060825 | HP_0001268 | G31.84 | — | 2 | — | — | 1 | 3 |
| Chemical and drug induced liver injury | D056486 | EFO_0004228 | — | 2 | 3 | — | — | — | 3 |
| Chronic chemical and drug induced liver injury | D056487 | EFO_1000905 | — | 2 | 2 | — | — | — | 2 |
| End stage liver disease | D058625 | EFO_1001311 | K72.1 | 1 | 2 | — | — | — | 2 |
| Acute-on-chronic liver failure | D065290 | — | — | 1 | 2 | — | — | — | 2 |
| Chronic hepatitis | D006521 | — | K73.9 | — | 1 | — | — | — | 1 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | — | 1 | — | — | — | 1 |
| Disease | D004194 | EFO_0000408 | R69 | — | 1 | — | — | — | 1 |
Show 11 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hepatocellular carcinoma | D006528 | — | C22.0 | 1 | — | — | — | 2 | 3 |
| Hyperhomocysteinemia | D020138 | — | — | 1 | — | — | — | 1 | 2 |
| Recurrence | D012008 | — | — | 1 | — | — | — | 1 | 2 |
| Carcinoma | D002277 | — | C80.0 | 1 | — | — | — | 1 | 2 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Metabolic syndrome | D024821 | EFO_0000195 | E88.810 | — | — | — | — | 1 | 1 |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | — | — | — | — | 1 | 1 |
| Mesenchymal stem cell transplantation | D045164 | — | — | — | — | — | — | 1 | 1 |
| Alcoholic fatty liver | D005235 | — | K70.0 | — | — | — | — | 1 | 1 |
| Alcoholism | D000437 | EFO_0003829 | F10.1 | — | — | — | — | 1 | 1 |
| Abdominal pain | D015746 | HP_0002027 | R10.9 | — | — | — | — | 1 | 1 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | — | — | — | 1 | 1 |
| Sclerosing cholangitis | D015209 | EFO_0004268 | K83.01 | — | — | — | — | 1 | 1 |
| Cholangitis | D002761 | HP_0030151 | K83.0 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Ademetionine |
| INN | ademetionine |
| Description | S-Adenosyl methionine (SAM), also known under the commercial names of SAMe, SAM-e, or AdoMet, is a common cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation. Although these anabolic reactions occur throughout the body, most SAM is produced and consumed in the liver. More than 40 methyl transfers from SAM are known, to various substrates such as nucleic acids, proteins, lipids and secondary metabolites. It is made from adenosine triphosphate (ATP) and methionine by methionine adenosyltransferase. SAM was first discovered by Giulio Cantoni in 1952.
|
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[S+](CC[C@H](N)C(=O)[O-])C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O |
Identifiers
| PDB | — |
| CAS-ID | 29908-03-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1088977 |
| ChEBI ID | 67040 |
| PubChem CID | 9865604 |
| DrugBank | — |
| UNII ID | 7LP2MPO46S (ChemIDplus, GSRS) |
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Trends
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Safety
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430 adverse events reported
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