Ademetionine
Ademetionine is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Clinical Trials
69 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Depressive disorder | D003866 | EFO_1002014 | F32.A | 1 | 3 | 1 | 1 | 2 | 7 |
| Hepatitis | D006505 | — | K75.9 | — | 3 | 2 | 2 | — | 6 |
| Liver failure | D017093 | — | K72.9 | 1 | 2 | — | 2 | 1 | 5 |
| Alcoholic liver diseases | D008108 | EFO_0008573 | K70 | — | 1 | 2 | 1 | 1 | 5 |
| Hepatitis a | D006506 | EFO_0007305 | B15 | — | 2 | 1 | 2 | — | 4 |
| Hepatitis b | D006509 | — | — | — | — | — | 2 | 1 | 3 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | 1 | 1 | — | 1 | — | 3 |
| End stage liver disease | D058625 | EFO_1001311 | K72.1 | 1 | 2 | — | 1 | — | 3 |
| Fibrosis | D005355 | — | — | — | 1 | — | 2 | — | 3 |
| Cholestasis | D002779 | — | K83.1 | — | — | 1 | 2 | — | 3 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Liver diseases | D008107 | EFO_0001421 | K70-K77 | — | 1 | 3 | — | 2 | 6 |
| Depression | D003863 | — | F33.9 | — | 3 | 1 | — | 3 | 6 |
| Non-alcoholic fatty liver disease | D065626 | EFO_0003095 | K75.81 | — | — | 2 | — | 2 | 4 |
| Fatty liver | D005234 | EFO_0003934 | — | — | — | 2 | — | 2 | 4 |
| Hepatitis c | D006526 | — | B19.2 | — | 3 | 1 | — | — | 3 |
| Chronic hepatitis c | D019698 | EFO_0004220 | B18.2 | — | 2 | 1 | — | — | 2 |
| Arthritis | D001168 | EFO_0005856 | M05-M14 | — | — | 1 | — | 1 | 2 |
| Juvenile arthritis | D001171 | EFO_1002007 | M08 | — | — | 1 | — | — | 1 |
| Prostatic neoplasms | D011471 | — | C61 | — | — | 1 | — | — | 1 |
| Adenocarcinoma | D000230 | — | — | — | — | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chemical and drug induced liver injury | D056486 | EFO_0004228 | — | 2 | 3 | — | — | 1 | 4 |
| Cognitive dysfunction | D060825 | — | G31.84 | — | 2 | — | — | 1 | 3 |
| Hepatic insufficiency | D048550 | — | — | 1 | 2 | — | — | 1 | 3 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 1 | 1 | — | — | 1 | 3 |
| Chronic chemical and drug induced liver injury | D056487 | EFO_1000905 | — | 2 | 2 | — | — | — | 2 |
| Acute-on-chronic liver failure | D065290 | — | — | 1 | 2 | — | — | — | 2 |
| Chronic hepatitis | D006521 | — | K73.9 | — | 1 | — | — | — | 1 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | — | 1 | — | — | — | 1 |
| Disease | D004194 | EFO_0000408 | R69 | — | 1 | — | — | — | 1 |
| Hot flashes | D019584 | — | — | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hepatocellular carcinoma | D006528 | — | C22.0 | 1 | — | — | — | 2 | 3 |
| Hyperhomocysteinemia | D020138 | — | — | 1 | — | — | — | 1 | 2 |
| Recurrence | D012008 | — | — | 1 | — | — | — | 1 | 2 |
| Carcinoma | D002277 | — | C80.0 | 1 | — | — | — | 1 | 2 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | — | — | — | — | 4 | 4 |
| Severe acute malnutrition | D000067011 | — | — | — | — | — | — | 3 | 3 |
| Alcoholic fatty liver | D005235 | — | K70.0 | — | — | — | — | 2 | 2 |
| Metabolic syndrome | D024821 | EFO_0000195 | E88.810 | — | — | — | — | 1 | 1 |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | — | — | — | — | 1 | 1 |
| Mesenchymal stem cell transplantation | D045164 | — | — | — | — | — | — | 1 | 1 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | — | — | — | 1 | 1 |
| Anesthesia | D000758 | — | — | — | — | — | — | 1 | 1 |
| Tuberculosis | D014376 | EFO_0000774 | A15-A19 | — | — | — | — | 1 | 1 |
| Pelvic organ prolapse | D056887 | EFO_0004710 | — | — | — | — | — | 1 | 1 |
Show 15 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Ademetionine |
| INN | ademetionine |
| Description | S-Adenosyl methionine (SAM), also known under the commercial names of SAMe, SAM-e, or AdoMet, is a common cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation. Although these anabolic reactions occur throughout the body, most SAM is produced and consumed in the liver. More than 40 methyl transfers from SAM are known, to various substrates such as nucleic acids, proteins, lipids and secondary metabolites. It is made from adenosine triphosphate (ATP) and methionine by methionine adenosyltransferase. SAM was first discovered by Giulio Cantoni in 1952.
|
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[S+](CC[C@H](N)C(=O)[O-])C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O |
Identifiers
| PDB | — |
| CAS-ID | 29908-03-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1088977 |
| ChEBI ID | 67040 |
| PubChem CID | 9865604 |
| DrugBank | — |
| UNII ID | 7LP2MPO46S (ChemIDplus, GSRS) |
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Safety
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Adverse Events
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149 adverse events reported
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