Ademetionine
Ademetionine is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Clinical Trials
69 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Liver diseases | D008107 | EFO_0001421 | K70-K77 | — | — | 3 | — | — | 3 |
| Alcoholic liver diseases | D008108 | EFO_0008573 | K70 | — | — | 2 | — | — | 2 |
| Non-alcoholic fatty liver disease | D065626 | EFO_0003095 | K75.81 | — | — | 1 | — | — | 1 |
| Fatty liver | D005234 | EFO_0003934 | — | — | — | 1 | — | — | 1 |
| Cholestasis | D002779 | — | K83.1 | — | — | 1 | — | — | 1 |
| Intrahepatic cholestasis | D002780 | — | — | — | — | 1 | — | — | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Ademetionine |
| INN | ademetionine |
| Description | S-Adenosyl methionine (SAM), also known under the commercial names of SAMe, SAM-e, or AdoMet, is a common cosubstrate involved in methyl group transfers, transsulfuration, and aminopropylation. Although these anabolic reactions occur throughout the body, most SAM is produced and consumed in the liver. More than 40 methyl transfers from SAM are known, to various substrates such as nucleic acids, proteins, lipids and secondary metabolites. It is made from adenosine triphosphate (ATP) and methionine by methionine adenosyltransferase. SAM was first discovered by Giulio Cantoni in 1952.
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| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[S+](CC[C@H](N)C(=O)[O-])C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O |
Identifiers
| PDB | — |
| CAS-ID | 29908-03-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1088977 |
| ChEBI ID | 67040 |
| PubChem CID | 9865604 |
| DrugBank | — |
| UNII ID | 7LP2MPO46S (ChemIDplus, GSRS) |
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Safety
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147 adverse events reported
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