Acetylcholine
Miochol (acetylcholine) is a small molecule pharmaceutical. Acetylcholine was first approved as Miochol on 1982-01-01. It is used to treat compassion fatigue and headache in the USA. It is known to target muscarinic acetylcholine receptor M4, muscarinic acetylcholine receptor M3, muscarinic acetylcholine receptor M5, muscarinic acetylcholine receptor M2, and muscarinic acetylcholine receptor M1.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Miochol (discontinued: Miochol)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Acetylcholine chloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| MIOCHOL-E | Bausch Health Companies | N-020213 RX | 1993-09-22 | 1 products, RLD, RS |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| miochol e | New Drug Application | 2023-03-17 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| headache | HP_0002315 | D006261 | R51 |
| compassion fatigue | — | D000068376 | — |
Agency Specific
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Clinical
Clinical Trials
1202 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Muscle spasticity | D009128 | HP_0001257 | — | 4 | 17 | 43 | 23 | 37 | 116 |
| Overactive urinary bladder | D053201 | EFO_1000781 | N32.81 | 7 | 14 | 21 | 18 | 19 | 75 |
| Stroke | D020521 | EFO_0000712 | I63.9 | 2 | 11 | 26 | 15 | 18 | 67 |
| Cerebral palsy | D002547 | — | G80 | 2 | 10 | 21 | 8 | 16 | 53 |
| Dystonia | D004421 | HP_0001332 | G24 | 5 | 8 | 15 | 9 | 19 | 52 |
| Torticollis | D014103 | HP_0000473 | F45.8 | 4 | 8 | 12 | 10 | 14 | 46 |
| Dystonic disorders | D020821 | — | G24 | 5 | 7 | 15 | 7 | 16 | 46 |
| Syndrome | D013577 | — | — | 7 | 22 | 10 | 6 | 8 | 45 |
| Migraine disorders | D008881 | EFO_0003821 | G43 | 2 | 6 | 12 | 10 | 15 | 43 |
| Urinary incontinence | D014549 | HP_0000020 | R32 | 3 | 5 | 13 | 9 | 6 | 33 |
Show 156 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myasthenia gravis | D009157 | EFO_0004991 | G70.0 | 1 | 2 | 7 | — | 4 | 12 |
| Muscle weakness | D018908 | HP_0001324 | — | 1 | 2 | 7 | — | 4 | 12 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | 1 | 5 | 1 | — | 4 | 11 |
| Traumatic brain injuries | D000070642 | — | S06 | — | 4 | 5 | — | 2 | 10 |
| Sialorrhea | D012798 | HP_0002307 | K11.7 | — | 4 | 8 | — | 1 | 10 |
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | 1 | 5 | 2 | — | 2 | 8 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | 2 | 3 | 2 | — | 1 | 8 |
| Prostatic hyperplasia | D011470 | EFO_0000284 | N40 | 2 | 5 | 2 | — | 1 | 8 |
| Hyperplasia | D006965 | EFO_0000536 | — | 2 | 5 | 2 | — | 1 | 8 |
| Tennis elbow | D013716 | EFO_1001896 | M77.1 | — | — | 5 | — | 3 | 8 |
Show 74 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ischemia | D007511 | EFO_0000556 | — | 2 | 1 | — | — | 10 | 12 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | 1 | 1 | — | — | 7 | 9 |
| Coronary artery disease | D003324 | — | I25.1 | 1 | 1 | — | — | 7 | 9 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | 1 | — | — | 7 | 8 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | 1 | — | — | 5 | 6 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | 3 | 1 | — | — | 1 | 5 |
| Muscle cramp | D009120 | HP_0003394 | — | 1 | 3 | — | — | 2 | 5 |
| Inflammation | D007249 | MP_0001845 | — | 1 | 1 | — | — | 3 | 5 |
| Hernia | D006547 | HP_0100790 | K40-K46 | — | 1 | — | — | 3 | 4 |
| Dysphonia | D055154 | — | R49.0 | 2 | 2 | — | — | 2 | 4 |
Show 87 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Vasodilation | D014664 | — | — | 3 | — | — | — | 3 | 6 |
| Vascular diseases | D014652 | EFO_0004264 | I77 | 1 | — | — | — | 4 | 5 |
| Obstructive lung diseases | D008173 | HP_0006536 | — | 3 | — | — | — | — | 3 |
| Heart failure | D006333 | HP_0001635 | I50 | 1 | — | — | — | 1 | 2 |
| Pulmonary arterial hypertension | D000081029 | — | — | 1 | — | — | — | 1 | 2 |
| Neurologic gait disorders | D020233 | HP_0003376 | R26.1 | 1 | — | — | — | 1 | 2 |
| Skin abnormalities | D012868 | HP_0000951 | Q82.9 | 1 | — | — | — | 1 | 2 |
| Vasoconstriction | D014661 | — | — | 2 | — | — | — | — | 2 |
| Tobacco smoking | D000073869 | — | — | 2 | — | — | — | — | 2 |
| Autism spectrum disorder | D000067877 | HP_0000729 | F84.0 | 1 | — | — | — | 1 | 2 |
Show 30 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Microvascular angina | D017566 | — | — | — | — | — | — | 9 | 9 |
| Coronary vasospasm | D003329 | EFO_0004225 | — | — | — | — | — | 7 | 7 |
| Atherosclerosis | D050197 | EFO_0003914 | I25.1 | — | — | — | — | 5 | 5 |
| Angina pectoris | D000787 | EFO_0003913 | I20 | — | — | — | — | 5 | 5 |
| Variant angina pectoris | D000788 | — | I20.1 | — | — | — | — | 4 | 4 |
| Coronary disease | D003327 | — | — | — | — | — | — | 4 | 4 |
| Ultrasonography | D014463 | — | — | — | — | — | — | 2 | 2 |
| Flushing | D005483 | — | R23.2 | — | — | — | — | 2 | 2 |
| Foot ulcer | D016523 | — | — | — | — | — | — | 2 | 2 |
| Complex regional pain syndromes | D020918 | EFO_1001998 | — | — | — | — | — | 2 | 2 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Acetylcholine |
| INN | acetylcholine chloride |
| Description | Acetylcholine is actylcholine is an ester of acetic acid and choline, which acts as a neurotransmitter. It has a role as a vasodilator agent, a muscarinic agonist, a hormone, a human metabolite, a mouse metabolite and a neurotransmitter. It is an acetate ester and an acylcholine. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(=O)OCC[N+](C)(C)C |
Identifiers
| PDB | — |
| CAS-ID | 51-84-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL667 |
| ChEBI ID | 15355 |
| PubChem CID | 187 |
| DrugBank | DB03128 |
| UNII ID | AF73293C2R (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
CHRM4
CHRM4
CHRM3
CHRM3
CHRM5
CHRM5
CHRM2
CHRM2
CHRM1
CHRM1
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Safety
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165 adverse events reported
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