Acetylcholine
Miochol (acetylcholine) is a small molecule pharmaceutical. Acetylcholine was first approved as Miochol on 1982-01-01. It is used to treat compassion fatigue and headache in the USA. It is known to target muscarinic acetylcholine receptor M4, muscarinic acetylcholine receptor M3, muscarinic acetylcholine receptor M5, muscarinic acetylcholine receptor M2, and muscarinic acetylcholine receptor M1.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Mock data
Subscribe for the real data
Subscribe for the real data
Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Miochol (discontinued: Miochol)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Acetylcholine chloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| MIOCHOL-E | Bausch Health Companies | N-020213 RX | 1993-09-22 | 1 products, RLD, RS |
Show 1 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| miochol e | New Drug Application | 2023-03-17 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| headache | — | D006261 | R51 |
| compassion fatigue | — | D000068376 | — |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
239 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | 4 | 4 | 2 | 3 | 13 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | 2 | 1 | 1 | 7 | 11 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | 3 | 1 | — | 1 | 5 | 10 |
| Hypertension | D006973 | EFO_0000537 | I10 | 2 | — | — | 1 | 5 | 8 |
| Cognitive dysfunction | D060825 | — | G31.84 | 1 | 1 | 3 | 2 | — | 7 |
| Dementia | D003704 | EFO_0003862 | F03 | 1 | — | 1 | 2 | 2 | 6 |
| Tobacco use disorder | D014029 | — | F17 | 1 | 2 | — | 1 | 2 | 6 |
| Smoking cessation | D016540 | EFO_0004319 | — | 1 | 2 | — | 2 | — | 5 |
| Pain | D010146 | EFO_0003843 | R52 | 1 | 1 | — | 2 | — | 4 |
| Stroke | D020521 | EFO_0000712 | I63.9 | 1 | — | — | 1 | 2 | 4 |
Show 37 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myasthenia gravis | D009157 | EFO_0004991 | G70.0 | 1 | 2 | 10 | — | 5 | 16 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | 1 | 5 | 1 | — | 5 | 12 |
| Muscle weakness | D018908 | — | — | 1 | 2 | 6 | — | 3 | 10 |
| Depression | D003863 | — | F33.9 | — | — | 2 | — | — | 2 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | — | — | 2 | — | — | 2 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | — | — | 2 | — | — | 2 |
| Anorexia | D000855 | — | R63.0 | — | 1 | 1 | — | — | 2 |
| Treatment-resistant depressive disorder | D061218 | — | — | — | — | 1 | — | — | 1 |
| Apathy | D057565 | — | — | — | — | 1 | — | — | 1 |
| Cachexia | D002100 | — | R64 | — | — | 1 | — | — | 1 |
Show 2 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ischemia | D007511 | EFO_0000556 | — | 2 | 1 | — | — | 8 | 10 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | 1 | 1 | — | — | 7 | 9 |
| Inflammation | D007249 | MP_0001845 | — | 1 | 1 | — | — | 3 | 5 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | 2 | — | — | 2 | 4 |
| Nervous system diseases | D009422 | — | G00-G99 | 1 | 2 | — | — | 1 | 4 |
| Cocaine-related disorders | D019970 | — | F14 | — | 4 | — | — | — | 4 |
| Dystonia | D004421 | — | — | — | 1 | — | — | 2 | 3 |
| Chronic renal insufficiency | D051436 | — | N18 | — | 1 | — | — | 2 | 3 |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | 1 | 2 | — | — | — | 3 |
| Central nervous system diseases | D002493 | — | G96.9 | 1 | 2 | — | — | — | 3 |
Show 22 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 3 | — | — | — | 8 | 11 |
| Coronary artery disease | D003324 | — | I25.1 | 1 | — | — | — | 9 | 10 |
| Vasodilation | D014664 | — | — | 3 | — | — | — | 3 | 6 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | 3 | — | — | — | 1 | 4 |
| Vascular diseases | D014652 | EFO_0004264 | I77 | 1 | — | — | — | 3 | 4 |
| Gestational diabetes | D016640 | — | O24.4 | 3 | — | — | — | — | 3 |
| Heart failure | D006333 | EFO_0003144 | I50 | 1 | — | — | — | 1 | 2 |
| Pulmonary arterial hypertension | D000081029 | — | — | 1 | — | — | — | 1 | 2 |
| Familial primary pulmonary hypertension | D065627 | — | I27.0 | 1 | — | — | — | 1 | 2 |
| Vasoconstriction | D014661 | — | — | 2 | — | — | — | — | 2 |
Show 26 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Microvascular angina | D017566 | — | — | — | — | — | — | 10 | 10 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | — | — | — | 9 | 9 |
| Angina pectoris | D000787 | EFO_0003913 | I20 | — | — | — | — | 7 | 7 |
| Coronary vasospasm | D003329 | EFO_0004225 | — | — | — | — | — | 7 | 7 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | — | — | — | 6 | 6 |
| Atherosclerosis | D050197 | EFO_0003914 | I25.1 | — | — | — | — | 5 | 5 |
| Variant angina pectoris | D000788 | — | I20.1 | — | — | — | — | 5 | 5 |
| Coronary disease | D003327 | — | — | — | — | — | — | 4 | 4 |
| Thrombosis | D013927 | — | — | — | — | — | — | 3 | 3 |
| Stable angina | D060050 | — | I20.89 | — | — | — | — | 3 | 3 |
Show 91 more
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | Acetylcholine |
| INN | acetylcholine chloride |
| Description | Acetylcholine is actylcholine is an ester of acetic acid and choline, which acts as a neurotransmitter. It has a role as a vasodilator agent, a muscarinic agonist, a hormone, a human metabolite, a mouse metabolite and a neurotransmitter. It is an acetate ester and an acylcholine. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(=O)OCC[N+](C)(C)C |
Identifiers
| PDB | — |
| CAS-ID | 51-84-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL667 |
| ChEBI ID | 15355 |
| PubChem CID | 187 |
| DrugBank | DB03128 |
| UNII ID | AF73293C2R (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
CHRM4
CHRM4
CHRM3
CHRM3
CHRM5
CHRM5
CHRM2
CHRM2
CHRM1
CHRM1
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 74,449 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
Subscribe for the real data
169 adverse events reported
View more details
© 2020-2025 Collaborative Drug Discovery Inc. (CDD) | Terms of Use