Acetylcholine
Miochol (acetylcholine) is a small molecule pharmaceutical. Acetylcholine was first approved as Miochol on 1982-01-01. It is used to treat compassion fatigue and headache in the USA. It is known to target muscarinic acetylcholine receptor M4, muscarinic acetylcholine receptor M3, muscarinic acetylcholine receptor M5, muscarinic acetylcholine receptor M2, and muscarinic acetylcholine receptor M1.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Miochol
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Acetylcholine chloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| MIOCHOL-E | Bausch Health Companies | N-020213 RX | 1993-09-22 | 1 products, RLD, RS |
Show 1 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| miochol e | New Drug Application | 2023-03-17 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| compassion fatigue | — | D000068376 | — |
| headache | HP_0002315 | D006261 | R51 |
Agency Specific
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Clinical
Clinical Trials
1143 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Overactive urinary bladder | D053201 | EFO_1000781 | N32.81 | 6 | 11 | 17 | 14 | 15 | 60 |
| Stroke | D020521 | EFO_0000712 | I63.9 | 2 | 10 | 18 | 15 | 15 | 56 |
| Cerebral palsy | D002547 | — | G80 | 2 | 10 | 20 | 6 | 14 | 48 |
| Torticollis | D014103 | HP_0000473 | F45.8 | 4 | 7 | 11 | 9 | 11 | 40 |
| Muscle spasticity | D009128 | HP_0001257 | — | — | 5 | 10 | 10 | 14 | 39 |
| Migraine disorders | D008881 | EFO_0003821 | G43 | 1 | 5 | 8 | 5 | 8 | 26 |
| Urinary incontinence | D014549 | HP_0000020 | R32 | 1 | 4 | 11 | 5 | 4 | 23 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | 2 | 4 | 4 | 5 | 8 | 22 |
| Blepharospasm | D001764 | — | G24.5 | 1 | 4 | 6 | 4 | 4 | 17 |
| Healthy volunteers/patients | — | — | — | 6 | — | 1 | 1 | 9 | 17 |
Show 98 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Alzheimer disease | D000544 | EFO_0000249 | F03 | 1 | 5 | 1 | — | 4 | 11 |
| Sialorrhea | D012798 | HP_0002307 | K11.7 | — | 4 | 8 | — | 1 | 10 |
| Prostatic hyperplasia | D011470 | EFO_0000284 | N40 | 2 | 5 | 2 | — | 1 | 8 |
| Traumatic brain injuries | D000070642 | — | S06 | — | 3 | 4 | — | 1 | 7 |
| Dystonia | D004421 | HP_0001332 | G24 | — | — | 1 | — | 6 | 7 |
| Tennis elbow | D013716 | EFO_1001896 | M77.1 | — | — | 5 | — | 2 | 7 |
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | 1 | 5 | 1 | — | 2 | 7 |
| Myasthenia gravis | D009157 | EFO_0004991 | G70.0 | 1 | 1 | 2 | — | 4 | 7 |
| Facial pain | D005157 | — | R51.9 | — | 3 | 1 | — | 1 | 5 |
| Erectile dysfunction | D007172 | EFO_0004234 | F52.21 | 1 | 5 | 2 | — | — | 5 |
Show 41 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cardiovascular diseases | D002318 | HP_0001626 | — | 1 | 1 | — | — | 6 | 8 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | — | 1 | — | — | 3 | 4 |
| Cocaine-related disorders | D019970 | — | F14 | — | 4 | — | — | — | 4 |
| Lower urinary tract symptoms | D059411 | EFO_0008008 | — | 1 | 1 | — | — | 1 | 3 |
| Neck pain | D019547 | HP_0030833 | M54.2 | 2 | 1 | — | — | 1 | 3 |
| Carpal tunnel syndrome | D002349 | EFO_0004143 | G56.0 | — | 3 | — | — | — | 3 |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | 1 | 2 | — | — | — | 3 |
| Central nervous system diseases | D002493 | HP_0002011 | G96.9 | 1 | 2 | — | — | — | 3 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | 1 | — | — | 2 | 3 |
| Smiling | D012904 | — | — | — | 1 | — | — | 1 | 2 |
Show 61 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Vasodilation | D014664 | — | — | 3 | — | — | — | 2 | 5 |
| Psoriasis | D011565 | EFO_0000676 | L40 | 2 | — | — | — | 1 | 3 |
| Inflammation | D007249 | MP_0001845 | — | 1 | — | — | — | 2 | 3 |
| Heart failure | D006333 | HP_0001635 | I50 | 1 | — | — | — | 1 | 2 |
| Pulmonary arterial hypertension | D000081029 | — | — | 1 | — | — | — | 1 | 2 |
| Skin abnormalities | D012868 | HP_0000951 | Q82.9 | 1 | — | — | — | 1 | 2 |
| Vasoconstriction | D014661 | — | — | 2 | — | — | — | — | 2 |
| Tobacco smoking | D000073869 | — | — | 2 | — | — | — | — | 2 |
| Autism spectrum disorder | D000067877 | HP_0000729 | F84.0 | 1 | — | — | — | 1 | 2 |
| Gestational diabetes | D016640 | HP_0009800 | O24.4 | 2 | — | — | — | — | 2 |
Show 18 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Microvascular angina | D017566 | — | — | — | — | — | — | 7 | 7 |
| Coronary vasospasm | D003329 | EFO_0004225 | — | — | — | — | — | 6 | 6 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | — | — | — | 4 | 4 |
| Vascular diseases | D014652 | EFO_0004264 | I77 | — | — | — | — | 3 | 3 |
| Esophageal motility disorders | D015154 | — | K22.4 | — | — | — | — | 2 | 2 |
| Diffuse esophageal spasm | D015155 | EFO_1001785 | K22.4 | — | — | — | — | 2 | 2 |
| Alopecia areata | D000506 | EFO_0004192 | L63 | — | — | — | — | 2 | 2 |
| Chronic renal insufficiency | D051436 | — | N18 | — | — | — | — | 2 | 2 |
| Fabry disease | D000795 | Orphanet_324 | E75.21 | — | — | — | — | 2 | 2 |
| Reperfusion injury | D015427 | — | — | — | — | — | — | 2 | 2 |
Show 80 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Acetylcholine |
| INN | acetylcholine chloride |
| Description | Acetylcholine is actylcholine is an ester of acetic acid and choline, which acts as a neurotransmitter. It has a role as a vasodilator agent, a muscarinic agonist, a hormone, a human metabolite, a mouse metabolite and a neurotransmitter. It is an acetate ester and an acylcholine. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(=O)OCC[N+](C)(C)C |
Identifiers
| PDB | — |
| CAS-ID | 51-84-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL667 |
| ChEBI ID | 15355 |
| PubChem CID | 187 |
| DrugBank | DB03128 |
| UNII ID | AF73293C2R (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
CHRM4
CHRM4
CHRM3
CHRM3
CHRM5
CHRM5
CHRM2
CHRM2
CHRM1
CHRM1
Variants
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Financial
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Trends
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Safety
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124 adverse events reported
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