Acetylcholine
Miochol (acetylcholine) is a small molecule pharmaceutical. Acetylcholine was first approved as Miochol on 1982-01-01. It is used to treat compassion fatigue and headache in the USA. It is known to target muscarinic acetylcholine receptor M4, muscarinic acetylcholine receptor M3, muscarinic acetylcholine receptor M5, muscarinic acetylcholine receptor M2, and muscarinic acetylcholine receptor M1.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Miochol (discontinued: Miochol)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Acetylcholine chloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| MIOCHOL-E | Bausch Health Companies | N-020213 RX | 1993-09-22 | 1 products, RLD, RS |
Show 1 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| miochol e | New Drug Application | 2023-03-17 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| headache | — | D006261 | R51 |
| compassion fatigue | — | D000068376 | — |
Agency Specific
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Clinical
Clinical Trials
255 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Alzheimer disease | D000544 | EFO_0000249 | F03 | 2 | 6 | 1 | 1 | 5 | 14 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | 4 | 4 | 2 | 3 | 13 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | 2 | 1 | 1 | 7 | 11 |
| Cognitive dysfunction | D060825 | — | G31.84 | 1 | 1 | 3 | 2 | 2 | 9 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | 1 | 1 | — | 1 | 5 | 8 |
| Hypertension | D006973 | EFO_0000537 | I10 | 2 | — | — | 1 | 4 | 7 |
| Dementia | D003704 | EFO_0003862 | F03 | 1 | — | 1 | 2 | 2 | 6 |
| Smoking cessation | D016540 | EFO_0004319 | — | 1 | 2 | 1 | 2 | — | 6 |
| Tobacco use disorder | D014029 | — | F17 | 1 | 2 | — | 1 | 2 | 6 |
| Stroke | D020521 | EFO_0000712 | I63.9 | 1 | — | — | 2 | 2 | 5 |
Show 36 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myasthenia gravis | D009157 | EFO_0004991 | G70.0 | 1 | 2 | 9 | — | 6 | 16 |
| Muscle weakness | D018908 | — | — | 1 | 1 | 1 | — | 2 | 4 |
| Depression | D003863 | — | F33.9 | — | — | 2 | — | 1 | 3 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | — | — | 2 | — | 1 | 3 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | — | — | 2 | — | — | 2 |
| Anorexia | D000855 | — | R63.0 | — | 1 | 1 | — | — | 2 |
| Treatment-resistant depressive disorder | D061218 | — | — | — | — | 1 | — | — | 1 |
| Apathy | D057565 | — | — | — | — | 1 | — | — | 1 |
| Cachexia | D002100 | — | R64 | — | — | 1 | — | — | 1 |
| Anesthesia | D000758 | — | — | — | 1 | 1 | — | — | 1 |
Show 1 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ischemia | D007511 | EFO_0000556 | — | 2 | 1 | — | — | 8 | 10 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | 1 | 1 | — | — | 7 | 9 |
| Inflammation | D007249 | MP_0001845 | — | 1 | 1 | — | — | 3 | 5 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | 2 | — | — | 2 | 4 |
| Cocaine-related disorders | D019970 | — | F14 | — | 4 | — | — | — | 4 |
| Dystonia | D004421 | — | — | — | 1 | — | — | 2 | 3 |
| Chronic renal insufficiency | D051436 | — | N18 | — | 1 | — | — | 2 | 3 |
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | 1 | 2 | — | — | — | 3 |
| Central nervous system diseases | D002493 | — | G96.9 | 1 | 2 | — | — | — | 3 |
| Nervous system diseases | D009422 | — | G00-G99 | 1 | 2 | — | — | — | 3 |
Show 27 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 4 | — | — | — | 8 | 12 |
| Coronary artery disease | D003324 | — | I25.1 | 1 | — | — | — | 9 | 10 |
| Vasodilation | D014664 | — | — | 3 | — | — | — | 3 | 6 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | 3 | — | — | — | 1 | 4 |
| Vascular diseases | D014652 | EFO_0004264 | I77 | 1 | — | — | — | 3 | 4 |
| Gestational diabetes | D016640 | — | O24.4 | 3 | — | — | — | — | 3 |
| Heart failure | D006333 | EFO_0003144 | I50 | 1 | — | — | — | 1 | 2 |
| Pulmonary arterial hypertension | D000081029 | — | — | 1 | — | — | — | 1 | 2 |
| Vasoconstriction | D014661 | — | — | 2 | — | — | — | — | 2 |
| Tobacco smoking | D000073869 | — | — | 2 | — | — | — | — | 2 |
Show 26 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Microvascular angina | D017566 | — | — | — | — | — | — | 10 | 10 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | — | — | — | 9 | 9 |
| Angina pectoris | D000787 | EFO_0003913 | I20 | — | — | — | — | 8 | 8 |
| Coronary vasospasm | D003329 | EFO_0004225 | — | — | — | — | — | 8 | 8 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | — | — | — | 6 | 6 |
| Variant angina pectoris | D000788 | — | I20.1 | — | — | — | — | 6 | 6 |
| Atherosclerosis | D050197 | EFO_0003914 | I25.1 | — | — | — | — | 5 | 5 |
| Spinal cord injuries | D013119 | EFO_1001919 | — | — | — | — | — | 4 | 4 |
| Thrombosis | D013927 | — | — | — | — | — | — | 3 | 3 |
| Stable angina | D060050 | — | I20.89 | — | — | — | — | 3 | 3 |
Show 95 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Acetylcholine |
| INN | acetylcholine chloride |
| Description | Acetylcholine is actylcholine is an ester of acetic acid and choline, which acts as a neurotransmitter. It has a role as a vasodilator agent, a muscarinic agonist, a hormone, a human metabolite, a mouse metabolite and a neurotransmitter. It is an acetate ester and an acylcholine. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(=O)OCC[N+](C)(C)C |
Identifiers
| PDB | — |
| CAS-ID | 51-84-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL667 |
| ChEBI ID | 15355 |
| PubChem CID | 187 |
| DrugBank | DB03128 |
| UNII ID | AF73293C2R (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
CHRM4
CHRM4
CHRM3
CHRM3
CHRM5
CHRM5
CHRM2
CHRM2
CHRM1
CHRM1
Variants
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Trends
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Safety
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Adverse Events
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170 adverse events reported
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