Therapeutic Area | MeSH |
---|---|
neoplasms | D009369 |
urogenital diseases | D000091642 |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
ZYTIGA | Johnson & Johnson | N-202379 RX | 2011-04-28 | 2 products, RLD |
YONSA | Sun Pharmaceutical Industries | N-210308 RX | 2018-05-22 | 1 products, RLD, RS |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
AKEEGA | Johnson & Johnson | N-216793 RX | 2023-08-11 | 2 products, RLD, RS |
Brand Name | Status | Last Update |
---|---|---|
abiraterone | ANDA | 2025-08-19 |
abiraterone acetate | ANDA | 2025-09-16 |
abirtega | ANDA | 2025-02-28 |
akeega | New Drug Application | 2024-08-19 |
yonsa | Export only | 2025-09-22 |
zytiga | New Drug Application | 2025-03-28 |
Expiration | Code | ||
---|---|---|---|
ABIRATERONE ACETATE / NIRAPARIB TOSYLATE, AKEEGA, JANSSEN BIOTECH | |||
2026-08-11 | NP |
Patent | Expires | Flag | FDA Information |
---|---|---|---|
Abiraterone Acetate / Niraparib Tosylate, Akeega, Janssen Biotech | |||
11091459 | 2038-03-27 | DS, DP | |
11673877 | 2038-03-27 | DS, DP | |
11207311 | 2037-07-28 | U-2830 | |
8859562 | 2031-08-04 | U-2830 | |
8071623 | 2031-03-27 | DS, DP | |
8436185 | 2029-04-24 | DS, DP | |
8071579 | 2027-08-12 | U-2830 | |
8143241 | 2027-08-12 | U-2830 | |
Abiraterone Acetate, Yonsa, Sun Pharm | |||
10292990 | 2034-05-20 | U-2535 | |
9889144 | 2034-03-17 | DP |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Prostatic neoplasms | D011471 | — | C61 | 93 | 210 | 56 | 7 | 60 | 385 |
Castration-resistant prostatic neoplasms | D064129 | — | — | 41 | 70 | 22 | 4 | 16 | 131 |
Carcinoma | D002277 | — | C80.0 | 2 | 12 | — | 1 | — | 15 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Adenocarcinoma | D000230 | — | — | 4 | 23 | 2 | — | 4 | 32 |
Neoplasm metastasis | D009362 | EFO_0009708 | — | 5 | 9 | 4 | — | 5 | 20 |
Neoplasms | D009369 | — | C80 | 10 | 6 | 2 | — | 3 | 18 |
Hypersensitivity | D006967 | EFO_0003785 | T78.40 | 1 | 7 | 2 | — | 3 | 13 |
Breast neoplasms | D001943 | EFO_0003869 | C50 | 7 | 6 | 1 | — | — | 11 |
Urogenital neoplasms | D014565 | EFO_0003863 | D07 | 2 | 2 | 1 | — | 1 | 4 |
Recurrence | D012008 | — | — | 1 | 2 | 1 | — | — | 3 |
Pain | D010146 | EFO_0003843 | R52 | — | — | 1 | — | 1 | 2 |
X-linked bulbo-spinal atrophy | D055534 | Orphanet_139557 | — | 1 | 1 | 1 | — | — | 2 |
Directly observed therapy | D023801 | — | — | — | — | 1 | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Non-small-cell lung carcinoma | D002289 | — | — | 6 | 3 | — | — | — | 8 |
Colorectal neoplasms | D015179 | — | — | 5 | 1 | — | — | — | 5 |
Urologic neoplasms | D014571 | — | C64-C68 | 1 | 2 | — | — | — | 3 |
Lung neoplasms | D008175 | — | C34.90 | 2 | 1 | — | — | — | 3 |
Congenital adrenal hyperplasia | D000312 | — | E25.0 | 2 | 1 | — | — | — | 3 |
Male genital neoplasms | D005834 | — | — | 2 | 2 | — | — | 1 | 3 |
Neoadjuvant therapy | D020360 | — | — | — | 3 | — | — | — | 3 |
Melanoma | D008545 | — | — | 1 | 2 | — | — | — | 2 |
Urinary bladder neoplasms | D001749 | — | C67 | — | 2 | — | — | — | 2 |
Transitional cell carcinoma | D002295 | — | — | — | 2 | — | — | — | 2 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Healthy volunteers/patients | — | — | — | 10 | — | — | — | — | 10 |
Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 3 | — | — | — | — | 3 |
Triple negative breast neoplasms | D064726 | — | — | 3 | — | — | — | — | 3 |
Ovarian epithelial carcinoma | D000077216 | — | — | 2 | — | — | — | — | 2 |
Pharmacokinetics | D010599 | — | — | 2 | — | — | — | — | 2 |
Renal cell carcinoma | D002292 | EFO_0000376 | — | 1 | — | — | — | — | 1 |
Endometrial neoplasms | D016889 | EFO_0004230 | — | 1 | — | — | — | — | 1 |
Hepatocellular carcinoma | D006528 | — | C22.0 | 1 | — | — | — | — | 1 |
Stomach neoplasms | D013274 | EFO_0003897 | C16 | 1 | — | — | — | — | 1 |
Head and neck neoplasms | D006258 | — | — | 1 | — | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Disease resistance | D060467 | — | — | — | — | — | — | 1 | 1 |
Bone fractures | D050723 | EFO_0003931 | T14.8 | — | — | — | — | 1 | 1 |
Pharmacogenomic testing | D000071185 | — | — | — | — | — | — | 1 | 1 |
Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | — | — | — | — | 1 | 1 |
Heart failure | D006333 | EFO_0003144 | I50 | — | — | — | — | 1 | 1 |
Cardiotoxicity | D066126 | EFO_1001482 | — | — | — | — | — | 1 | 1 |
Cardiac arrhythmias | D001145 | EFO_0004269 | I49.9 | — | — | — | — | 1 | 1 |
Tachycardia | D013610 | — | R00.0 | — | — | — | — | 1 | 1 |
Supraventricular tachycardia | D013617 | — | I47.1 | — | — | — | — | 1 | 1 |
Male genital diseases | D005832 | EFO_0009555 | N50.9 | — | — | — | — | 1 | 1 |
Drug common name | Abiraterone |
INN | abiraterone |
Description | Abiraterone acetate is a sterol ester obtained by formal condensation of the 3-hydroxy group of abiraterone with the carboxy group of acetic acid. A prodrug that is converted in vivo into abiraterone. Used for treatment of metastatic castrate-resistant prostate cancer. It has a role as a prodrug, an antineoplastic agent and an EC 1.14.99.9 (steroid 17alpha-monooxygenase) inhibitor. It is a sterol ester and a member of pyridines. It is functionally related to an abiraterone. |
Classification | Small molecule |
Drug class | antiandrogens |
Image (chem structure or protein) | ![]() |
Structure (InChI/SMILES or Protein Sequence) | C[C@]12CC[C@H]3[C@@H](CC=C4C[C@@H](O)CC[C@@]43C)[C@@H]1CC=C2c1cccnc1 |
PDB | — |
CAS-ID | 154229-19-3 |
RxCUI | — |
ChEMBL ID | CHEMBL254328 |
ChEBI ID | 68642 |
PubChem CID | 9821849 |
DrugBank | DBSALT001173 |
UNII ID | G819A456D0 (ChemIDplus, GSRS) |