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AboutPricing
Drug ReportsAbiraterone
Zytiga(abiraterone)
Abiraterone, Akeega, Yonsa, Zytiga (abiraterone) is a small molecule pharmaceutical. Abiraterone was first approved as Zytiga on 2011-04-28. It is used to treat castration-resistant prostatic neoplasms in the USA. It has been approved in Europe to treat castration-resistant prostatic neoplasms and prostatic neoplasms. The pharmaceutical is active against steroid 17-alpha-hydroxylase/17,20 lyase.
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Commercial
Clinical
Drug
Target
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Financial
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Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
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Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
neoplasmsD009369
urogenital diseasesD000091642
Trade Name
FDA
EMA
Abiraterone, Yonsa, Zytiga (discontinued: Abiraterone)
Combinations
Akeega
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Abiraterone acetate
Tradename
Company
Number
Date
Products
ZYTIGAJohnson & JohnsonN-202379 RX2011-04-28
2 products, RLD
YONSASun Pharmaceutical IndustriesN-210308 RX2018-05-22
1 products, RLD, RS
Abiraterone acetate
+
Niraparib tosylate
Tradename
Company
Number
Date
Products
AKEEGAJohnson & JohnsonN-216793 RX2023-08-11
2 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
abirateroneANDA2025-08-19
abiraterone acetateANDA2025-09-16
abirtegaANDA2025-02-28
akeegaNew Drug Application2024-08-19
yonsaExport only2025-09-22
zytigaNew Drug Application2025-03-28
Agency Specific
FDA
EMA
Expiration
Code
ABIRATERONE ACETATE / NIRAPARIB TOSYLATE, AKEEGA, JANSSEN BIOTECH
2026-08-11NP
Patent Expiration
Patent
Expires
Flag
FDA Information
Abiraterone Acetate / Niraparib Tosylate, Akeega, Janssen Biotech
110914592038-03-27DS, DP
116738772038-03-27DS, DP
112073112037-07-28U-2830
88595622031-08-04U-2830
80716232031-03-27DS, DP
84361852029-04-24DS, DP
80715792027-08-12U-2830
81432412027-08-12U-2830
Abiraterone Acetate, Yonsa, Sun Pharm
102929902034-05-20U-2535
98891442034-03-17DP
ATC Codes
L: Antineoplastic and immunomodulating agents
L02: Endocrine therapy antineoplastic and immunomodulating agents
L02B: Hormone antagonists and related agents
L02BX: Other hormone antagonists and related agents in atc
L02BX03: Abiraterone
HCPCS
No data
Clinical
Clinical Trials
452 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Prostatic neoplasmsD011471C619321056760385
Castration-resistant prostatic neoplasmsD064129417022416131
CarcinomaD002277C80.0212115
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Non-small-cell lung carcinomaD002289638
Colorectal neoplasmsD015179515
Urologic neoplasmsD014571C64-C68123
Lung neoplasmsD008175C34.90213
Congenital adrenal hyperplasiaD000312E25.0213
Male genital neoplasmsD0058342213
Neoadjuvant therapyD02036033
MelanomaD008545122
Urinary bladder neoplasmsD001749C6722
Transitional cell carcinomaD00229522
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients1010
Ovarian neoplasmsD010051EFO_0003893C5633
Triple negative breast neoplasmsD06472633
Ovarian epithelial carcinomaD00007721622
PharmacokineticsD01059922
Renal cell carcinomaD002292EFO_000037611
Endometrial neoplasmsD016889EFO_000423011
Hepatocellular carcinomaD006528C22.011
Stomach neoplasmsD013274EFO_0003897C1611
Head and neck neoplasmsD00625811
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Indications Without Phase
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameAbiraterone
INNabiraterone
Description
Abiraterone acetate is a sterol ester obtained by formal condensation of the 3-hydroxy group of abiraterone with the carboxy group of acetic acid. A prodrug that is converted in vivo into abiraterone. Used for treatment of metastatic castrate-resistant prostate cancer. It has a role as a prodrug, an antineoplastic agent and an EC 1.14.99.9 (steroid 17alpha-monooxygenase) inhibitor. It is a sterol ester and a member of pyridines. It is functionally related to an abiraterone.
Classification
Small molecule
Drug classantiandrogens
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
C[C@]12CC[C@H]3[C@@H](CC=C4C[C@@H](O)CC[C@@]43C)[C@@H]1CC=C2c1cccnc1
Identifiers
PDB
CAS-ID154229-19-3
RxCUI
ChEMBL IDCHEMBL254328
ChEBI ID68642
PubChem CID9821849
DrugBankDBSALT001173
UNII IDG819A456D0 (ChemIDplus, GSRS)
Target
Agency Approved
CYP17A1
CYP17A1
Organism
Homo sapiens
Gene name
CYP17A1
Gene synonyms
CYP17, S17AH
NCBI Gene ID
Protein name
steroid 17-alpha-hydroxylase/17,20 lyase
Protein synonyms
17-alpha-hydroxyprogesterone aldolase, CYPXVII, Cytochrome P450 17A1, cytochrome p450 XVIIA1, cytochrome P450, family 17, subfamily A, polypeptide 1, cytochrome P450, subfamily XVII (steroid 17-alpha-hydroxylase), adrenal hyperplasia, Cytochrome P450-C17, Cytochrome P450c17, Steroid 17-alpha-monooxygenase
Uniprot ID
Mouse ortholog
Cyp17a1 (13074)
steroid 17-alpha-hydroxylase/17,20 lyase (P27786)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
£
Zytiga Johnson & Johnson
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Estimated US medical usage
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 13,162 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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37,792 adverse events reported
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