Verzenio, Verzenios(abemaciclib)
Verzenio, Verzenios (abemaciclib) is a small molecule pharmaceutical. Abemaciclib was first approved as Verzenio on 2017-09-28. It has been approved in Europe to treat breast neoplasms. It is known to target cyclin-dependent kinase 6 and cyclin-dependent kinase 4.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| neoplasms | D009369 |
| skin and connective tissue diseases | D017437 |
Trade Name
FDA
EMA
Verzenio
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| verzenio | New Drug Application | 2024-01-03 |
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
ABEMACICLIB, VERZENIO, ELI LILLY AND CO | |||
| 2024-10-12 | I-877, NPP | ||
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Abemaciclib, Verzenio, Eli Lilly And Co | |||
| 7855211 | 2029-12-15 | DS, DP | U-1981, U-2132, U-2135, U-2251, U-3241, U-3242, U-3243, U-3265, U-3546 |
HCPCS
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Clinical
Clinical Trials
215 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 28 | 39 | 11 | 3 | 10 | 79 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 5 | 2 | 3 | 1 | — | 10 |
| Triple negative breast neoplasms | D064726 | — | — | 1 | 5 | 1 | 1 | 1 | 8 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 19 | 14 | 1 | — | 1 | 30 |
| Prostatic neoplasms | D011471 | — | C61 | 4 | 6 | 2 | — | — | 9 |
| Non-small-cell lung carcinoma | D002289 | — | — | 6 | 3 | 1 | — | — | 9 |
| Male breast neoplasms | D018567 | — | — | 1 | 1 | 3 | — | — | 5 |
| Liposarcoma | D008080 | — | — | — | 1 | 1 | — | — | 2 |
| Urogenital neoplasms | D014565 | EFO_0003863 | D07 | — | — | 1 | — | — | 1 |
| Diarrhea | D003967 | HP_0002014 | R19.7 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Endometrial neoplasms | D016889 | EFO_0004230 | — | 2 | 6 | — | — | — | 7 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 4 | 4 | — | — | — | 6 |
| Castration-resistant prostatic neoplasms | D064129 | — | — | 2 | 3 | — | — | — | 4 |
| Glioblastoma | D005909 | EFO_0000515 | — | 2 | 2 | — | — | — | 4 |
| Renal cell carcinoma | D002292 | EFO_0000376 | — | 4 | 1 | — | — | — | 4 |
| Colorectal neoplasms | D015179 | — | — | 4 | 2 | — | — | — | 4 |
| Head and neck neoplasms | D006258 | — | — | — | 4 | — | — | — | 4 |
| Squamous cell carcinoma of head and neck | D000077195 | — | — | 1 | 4 | — | — | — | 4 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 2 | 1 | — | — | — | 3 |
| Multiple myeloma | D009101 | — | C90.0 | 2 | 2 | — | — | — | 3 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 8 | — | — | — | — | 8 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 2 | — | — | — | — | 2 |
| Primary myelofibrosis | D055728 | — | D47.4 | 2 | — | — | — | — | 2 |
| Glioma | D005910 | EFO_0000520 | — | 2 | — | — | — | — | 2 |
| Myelodysplastic syndromes | D009190 | — | D46 | 1 | — | — | — | — | 1 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 1 | — | — | — | — | 1 |
| Hematologic neoplasms | D019337 | — | — | 1 | — | — | — | — | 1 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 1 | — | — | — | — | 1 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 1 | — | — | — | — | 1 |
| Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 1 | — | — | — | — | 1 |
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Abemaciclib |
| INN | abemaciclib |
| Description | Abemaciclib, sold under the brand name Verzenio among others, is a medication for the treatment of advanced or metastatic breast cancers. It was developed by Eli Lilly and it acts as a CDK inhibitor selective for CDK4 and CDK6.
|
| Classification | Small molecule |
| Drug class | cyclin dependent kinase inhibitors (formerly-cidib) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc(C)n(C(C)C)c5c4)n3)nc2)CC1 |
Identifiers
| PDB | — |
| CAS-ID | 1231929-97-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3301610 |
| ChEBI ID | — |
| PubChem CID | 46220502 |
| DrugBank | DB12001 |
| UNII ID | 60UAB198HK (ChemIDplus, GSRS) |
Target
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Verzenio – Eli Lilly
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Safety
Black-box Warning
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Adverse Events
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5,354 adverse events reported
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