Verzenio, Verzenios(abemaciclib)
Verzenio, Verzenios (abemaciclib) is a small molecule pharmaceutical. Abemaciclib was first approved as Verzenio on 2017-09-28. It has been approved in Europe to treat breast neoplasms. It is known to target cyclin-dependent kinase 6 and cyclin-dependent kinase 4.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| neoplasms | D009369 |
| skin and connective tissue diseases | D017437 |
Trade Name
FDA
EMA
Verzenio
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| verzenio | New Drug Application | 2024-11-13 |
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
ABEMACICLIB, VERZENIO, ELI LILLY AND CO | |||
| 2024-10-12 | I-877, NPP | ||
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Abemaciclib, Verzenio, Eli Lilly And Co | |||
| 7855211 | 2029-12-15 | DS, DP | U-1981, U-2132, U-2135, U-2251, U-3241, U-3242, U-3243, U-3265, U-3546 |
HCPCS
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Clinical
Clinical Trials
237 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 39 | 53 | 23 | 5 | 23 | 129 |
| Neoplasms | D009369 | — | C80 | 23 | 18 | 4 | 1 | 4 | 43 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 8 | 5 | 4 | 1 | 1 | 17 |
| Triple negative breast neoplasms | D064726 | — | — | 5 | 7 | 2 | 1 | 3 | 17 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Prostatic neoplasms | D011471 | — | C61 | 4 | 8 | 2 | — | — | 11 |
| Non-small-cell lung carcinoma | D002289 | — | — | 7 | 4 | 1 | — | — | 10 |
| Lung neoplasms | D008175 | — | C34.90 | 2 | 5 | 1 | — | — | 7 |
| Male breast neoplasms | D018567 | — | — | 1 | 1 | 3 | — | 1 | 6 |
| Liposarcoma | D008080 | — | — | 1 | 2 | 1 | — | — | 3 |
| Urogenital neoplasms | D014565 | EFO_0003863 | D07 | — | — | 1 | — | — | 1 |
| Hypersensitivity | D006967 | EFO_0003785 | T78.40 | — | — | 1 | — | — | 1 |
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | — | 1 | — | — | 1 |
| Diarrhea | D003967 | — | R19.7 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Carcinoma | D002277 | — | C80.0 | 13 | 15 | — | — | 1 | 25 |
| Adenocarcinoma | D000230 | — | — | 7 | 8 | — | — | 1 | 12 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 7 | 7 | — | — | — | 10 |
| Endometrial neoplasms | D016889 | EFO_0004230 | — | 3 | 8 | — | — | — | 9 |
| Recurrence | D012008 | — | — | 5 | 2 | — | — | 1 | 8 |
| Sarcoma | D012509 | — | — | 4 | 6 | — | — | — | 8 |
| Glioma | D005910 | EFO_0000520 | — | 5 | 2 | — | — | — | 6 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 2 | 6 | — | — | — | 6 |
| Glioblastoma | D005909 | EFO_0000515 | — | 3 | 3 | — | — | — | 5 |
| Colorectal neoplasms | D015179 | — | — | 5 | 2 | — | — | — | 5 |
Show 72 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 8 | — | — | — | — | 8 |
| Primary myelofibrosis | D055728 | — | D47.4 | 2 | — | — | — | — | 2 |
| Syndrome | D013577 | — | — | 1 | — | — | — | 1 | 2 |
| Leukemia | D007938 | — | C95 | 1 | — | — | — | — | 1 |
| Myelodysplastic syndromes | D009190 | — | D46 | 1 | — | — | — | — | 1 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 1 | — | — | — | — | 1 |
| Myeloproliferative disorders | D009196 | — | D47.1 | 1 | — | — | — | — | 1 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 1 | — | — | — | — | 1 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 1 | — | — | — | — | 1 |
| Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | — | 1 | — | — | — | — | 1 |
Show 27 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoadjuvant therapy | D020360 | — | — | — | — | — | — | 1 | 1 |
| Antineoplastic combined chemotherapy protocols | D000971 | — | — | — | — | — | — | 1 | 1 |
| Bone diseases | D001847 | — | M89.9 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Abemaciclib |
| INN | abemaciclib |
| Description | Abemaciclib, sold under the brand name Verzenio among others, is a medication for the treatment of advanced or metastatic breast cancers. It was developed by Eli Lilly and it acts as a CDK inhibitor selective for CDK4 and CDK6.
|
| Classification | Small molecule |
| Drug class | cyclin dependent kinase inhibitors (formerly-cidib) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCN1CCN(Cc2ccc(Nc3ncc(F)c(-c4cc(F)c5nc(C)n(C(C)C)c5c4)n3)nc2)CC1 |
Identifiers
| PDB | — |
| CAS-ID | 1231929-97-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3301610 |
| ChEBI ID | — |
| PubChem CID | 46220502 |
| DrugBank | DB12001 |
| UNII ID | 60UAB198HK (ChemIDplus, GSRS) |
Target
Agency Approved
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Variants
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Verzenio – Eli Lilly
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Trends
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Safety
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No Black-box warning
Adverse Events
Top Adverse Reactions
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13,143 adverse events reported
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